Impact of a Dietary Supplement Containing 1,3-Dimethylamylamine on Blood Pressure and Bloodborne Markers of Health: A 10-Week Intervention Study

Abstract

Background:1,3-dimethylamylamine is a commonly used ingredient within dietary supplements. Our prior work with this agent indicates a transient increase in blood pressure (systolic in particular) following oral ingestion of a single dosage, but no significant increase in resting blood pressure following chronic ingestion. Moreover, intervention studies involving both two and eight weeks of treatment with finished products containing 1,3-dimethylamylamine indicate minimal or no change in bloodborne markers of health. The present study sought to extend these findings by using a 10-week intervention trial to determine the change in selected markers of health in a sample of men.Methods:25 healthy men were randomly assigned to either a placebo (n = 13) or to a supplement containing 1,3-dimethylamylamine (n = 12) for a period of 10 weeks. Before and after the intervention, resting blood pressure and heart rate were measured, and blood samples were collected for determination of complete blood count, metabolic panel, and lipid panel.Results:No significant differences were noted between conditions for blood pressure (P > 0.05), although systolic blood pressure increased approximately 6 mmHg with the supplement (diastolic blood pressure decreased approximately 4 mmHg). A main effect for time was noted for heart rate (P = 0.016), with values decreasing from pre to post intervention. There were significant main effects for time for creatinine (increased from pre to post intervention; P = 0.043) and alkaline phosphatase (decreased from pre to post intervention; P = 0.009), with no condition differences noted (P > 0.05). There was a significant interaction noted for low density lipoprotein cholesterol (LDL-C) (P = 0.043), with values decreasing in the supplement group from pre to post intervention approximately 7 mg · dL−1 (P = 0.034). No other effects of significance were noted for bloodborne variables.Conclusion:These data indicate that a dietary supplement containing 1,3-dimethylamylamine does not result in a statistically significant increase in resting heart rate or blood pressure (although systolic blood pressure is increased ∼6 mmHg with supplement use). The supplement does not negatively impact bloodborne markers of health. Further study is needed involving a longer intervention period, a larger sample size, and additional measures of health and safety.

Effects of controlled doses of Oxyelite Pro on physical performance in rats

“…However, it is noteworthy that the subjects of both studies were regularly engaged in physical activity protocols (which may have contributed to the weight loss) and both studies were financed by USP Labs, the OEP manufacturer. Also, our results corroborate with data found by Whitehead et al [17], that no effect on body weight was observed with supplementation of 1–3 serving OEP during a period of 10 weeks without exercise training.…”

“…Other studies with long-term supplementation but with known amount of OEP found no difference in liver injury markers (AST, ALT and GGT) [3, 17, 24]. …”

“…Also, studies showing that those supplements are safe and well tolerated were from groups sponsored by its manufacturer, the USP labs [1, 3, 17, 18]. On the other hand, those studies showing serious adverse effects associated with OEP consumption were associated with poisoning or ingestion of a huge or unadvertised amount of the supplement.…”

Safety of a dose-escalated pre-workout supplement in recreationally active females

“…A follow up to this study conducted by Whitehead et al [21] supplemented with the same product containing caffeine and 1,3- dimethylamylamine (Jack3d™) over a 10-week period in healthy males and also found it did not negatively impact hematological markers of health when consumed daily.…”

- Consumption of Fructose-Sweetened Beverages for 10 Weeks Reduces Net Fat Oxidation and Energy Expenditure in Overweight/Obese Men and Women

“…A key ingredient 1,3-dimethylamylamine (also known as germanium, geranamine or DMAA) has been implicated for potential contraindications. DMAA is purported to increase both systolic and diastolic blood pressure in young and healthy men and women immediately following ingestion, although these observations have been inconsistent during longer treatments with OEP in young men [4][5][6][7]. DMAA is also purported to cause false-positive results for amphetamines on select immunoassays, a profound implication for athletes with sanctioned governing bodies [8].…”