Impact of 8-week linoleic acid intake in soy oil on Lp-PLA2 activity in healthy adults

Abstract

BackgroundNo intervention follow-up study has examined the association between plasma n-6 polyunsaturated fatty acids (PUFAs) and lipoprotein-associated phospholipase A2 (Lp-PLA2), which is a risk factor for cardiovascular disease (CVD). We aimed to determine whether the administration of linoleic acid (LA, 18:2n-6) in soy oil affected Lp-PLA2 activity in healthy adults.MethodsSelf-reported healthy participants (n = 150) were randomly assigned to three groups: a low LA group, in which 10 mL soy oil was replaced with one apple; a medium LA group, in which the typical food intake was maintained; and a high LA group, in which 1/3 cup of cooked refined rice was replaced with 9.9 g of soy oil capsules daily. Plasma fatty acids and Lp-PLA2 activity were measured along with other CVD risk factors.ResultsAfter 8 weeks of treatment, plasma LA levels decreased in the low LA group and increased in the high LA group. The high LA group showed greater increases in apolipoprotein B (apoB) and oxidized low-density lipoprotein (ox-LDL) than those in the low LA group. Plasma LA levels and Lp-PLA2 activities demonstrated greater increases in the high LA group than those in the medium and low LA groups. Changes in plasma LA positively and independently correlated with changes in Lp-PLA2 activity, which was negatively correlated with changes in collagen-epinephrine closure time (CEPI-CT).ConclusionsAn increase in plasma LA following intake of soy oil was independently associated with Lp-PLA2 activity, which was also related to apoB, ox-LDL and CEPI-CT.Trial registrationClinicalTrail.gov Identifier: NCT02753907, registered 25 April 2016 (retrospectively registered).Electronic supplementary materialThe online version of this article (doi:10.1186/s12986-017-0186-2) contains supplementary material, which is available to authorized users.

The Beneficial Effects of Alpha Lipoic Acid Supplementation on Lp-PLA2 Mass and Its Distribution between HDL and apoB-Containing Lipoproteins in Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

“…Furthermore, we found a positive correlation between the reduction in ox-LDL level and total Lp-PLA2 mass in the ALA group. Such a positive correlation has also been observed in other clinical studies [53][54][55].…”

Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions

“…A recent clinical trial reported increased plasma PLA2G7 activity in patients on a 8-week LA-rich diet 37 . Thus, we investigated changes in PLA2 activity from H6D afferent neurons by exposing purified DRG homogenates to a phospholipid reporter containing dual fluorogenic boron dipyrromethene (BODIPY) acyl chains ( Fig.…”

Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions

“…Elevated LA content has been associated with increased PLA2 activity, including in a recent clinical trial where increased PLA2G7 activity was observed in plasma from subjects on a 8-week LA-rich diet 37 . We evaluated for functional alterations in PLA2 activity in afferent neurons from H6D mice by exposing purified DRG homogenates to a phospholipid reporter containing dual fluorogenic boron dipyrromethene (BODIPY) acyl chains ( Fig.…”