Impact load transmission of the knee joint-influence of leg alignment and the role of meniscus and articular cartilage

Fukuda, Yukihisa; Takai, Shinro; Yoshino, Nobuyuki; Murase, Kouhei; Tsutsumi, Sadami; Ikeuchi, Ken; Hirasawa, Yasusuke

doi:10.1016/s0268-0033(00)00013-9

Cited by 68 publications

(46 citation statements)

References 14 publications

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“…If ZOL treatment is initiated at this stage, abnormalities in subchondral bone can be reversed to a large extent and then cartilage degeneration would be retarded accordingly. Conversely, at an advanced stage, subchondral bone accretion was increased mainly due to excessive mechanical stress [30][31][32] . If ZOL therapy is given at this stage, subchondral bone remodeling would not be reversible, and articular cartilage degeneration would continue.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model

Mao

et al. 2012

Acta Pharmacol Sin

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Aim: To investigate whether the stage of osteoarthritis (OA) progression influenced the efficacy of the third-generation bisphosphonate zoledronic acid in a rat medial meniscal tear model. Methods: Medial meniscal tear (MMT) was surgically induced in adult male Sprague Dawley rats. Zoledronic acid (ZOL, 100 μg/kg, sc, twice a week) was administered starting immediately, early (from 4 weeks) or late (from 8 weeks) after OA induction. The degeneration of articular cartilage was evaluated with toluidine blue O staining. Subchondral bone remodeling was evaluated with X-ray micro-CT scanning. Joint pain was measured with respect to weight-bearing asymmetry. Calcitonin gene-related peptide (CGRP) expression in dorsal root ganglia (DRGs) was examined using immunofluorescence analysis. The afferent neurons in DRGs innervating the joint were identified by retrograde labeling with fluorogold. Results: Progressive cartilage loss was observed during 12 weeks after OA induction. Subchondral bone remodeling manifested as increased bone resorption at early stage (4 weeks), but as increased bone accretion at advanced stages (8 weeks). Immediately and early ZOL administration significantly improved subchondral microstructural parameters, attenuated cartilage degeneration, reduced weight-bearing asymmetry and CGRP expression, whereas the late ZOL administration had no significant effects. Conclusion: The stage of OA progression influences the efficacy of ZOL in treating joint degeneration and pain. To obtain the maximum efficacy, bisphosphonate treatment should be initiated in rat with early stages of OA pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model

Mao

et al. 2012

Acta Pharmacol Sin

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“…It could be shown that porcine menisci have the same impact absorbing effect that was found in humans. 7,8 The major ligaments of the knee serve a similar function in humans and pigs. 9 A notable difference of the porcine knee is the absence of the posterior meniscotibial attachment of the lateral meniscus.…”

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confidence: 99%

Tensile forces at the porcine anterior meniscal horn attachment

Stärke

Kopf

Gröbel

et al. 2009

Journal Orthopaedic Research

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Tibiofemoral compression causes circumferential tension in the knee meniscus, which is transferred to the tibial bone at the anterior and posterior attachments. The objective of the study was to measure the resulting tensile forces at the horn attachment in a porcine model. The anterior horn attachment of the porcine medial meniscus (n ¼ 10) was separated from the surrounding bone with a core reamer. A force transducer was installed such that tensile forces acting upon the now mobile horn attachment could be measured. The tibiofemoral joint was loaded in compression, starting at a preload of 30 N, with three 150-N increments, giving 180, 330, and 480 N load. Flexion angles of 0, 30, and 608 were investigated. The average resultant tension at the horn attachment was 26.3, 40.6, and 55.4 N with full extension, 29.2, 47.8, and 62.2 N at 308 flexion and 30.1, 49.6, and 68.1 N at 608 flexion. The tibiofemoral compression had a significant effect on the tension (p < 0.001), whereas no influence of the flexion angle was found (p ¼ 0.291). The study demonstrates that tibiofemoral compressive loads cause considerable tensile forces at the anterior meniscal horn attachment. The data are of interest for models of the repair or replacement of the knee menisci. ß

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“…Las investigaciones recientes señalan la OA como un proceso degenerativo articular, originalmente no inflamatorio, cuyo factor desencadenante es la combinación de oscilación y aplicación de peso y carga 1 . El factor principal no es la cantidad de carga sino el mecanismo que la produce 2 .…”

Section: Fisiopatologíaunclassified

Osteartrosis y pie. Bases de tratamiento biorregulador

Acedo¹,

Bella²

2013

Rev. Int. Cienc. Podol.

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Fecha de recepción: 9 abril de 2010 Fecha de aceptación: 22 de febrero de 2011Los autores declaran no tener ningún tipo de interés económico o comercial. ReSuMenLa OsteoArtrosis (OA) es un síndrome complejo, que afecta a las estructuras no solo articulares sino periarticulares como ligamentos, tendones y sistema miofascial, generando un cuadro clínico en el que predomina los síntomas neurogénicos, a consecuencia de un fenómeno conocido como "facilitación" o "campo interferente". Las últimas investigaciones avalan como causa primaria de la OA las cargas inadecuadas soportadas por el complejo articular debido al mal alineamiento segmentario; y la inflamación sinovial, antaño causa inicial, como proceso secundario a la presencia de fragmentos cartilaginosos, debido a su deterioro, en el espacio articular. La Biopuntura de medicamentos Biorreguladores aporta una perspectiva terapéutica que abarca todos los elementos implicados en esta patología, su clínica y el proceso degenerativo del "órgano articular". Palabras clave: osteoartrosis; pie; condrocito; dolor; facilitación. AbStRACtOsteoarthritis (OA) is a complex syndrome, which affects not only the structures but periarticular joint such as ligaments, tendons and myofascial system, resulting in a clinically predominant neurogenic symptoms as a result of a phenomenon known as "facilitation" or "interference field." Recent investigations support as the primary cause of OA inappropriate burdens borne by the joint complex due to segmental malalignment, and synovial inflammation, once the initial cause, as a process secondary to the presence of cartilage fragments, due to deterioration in the joint space. The drug Biopuntura Bioregulators provides a therapeutic perspective that encompasses all the elements involved in this pathology, clinical history and the degenerative process of "joint authority."

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Impact load transmission of the knee joint-influence of leg alignment and the role of meniscus and articular cartilage

Cited by 68 publications

References 14 publications

Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model

Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model

Tensile forces at the porcine anterior meniscal horn attachment

Osteartrosis y pie. Bases de tratamiento biorregulador

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