Impact Factors for Microinvasion in Patients With Hepatocellular Carcinoma: Possible Application to the Definition of Clinical Tumor Volume

Wang, Minhua; Ji, Yuan; Zeng, Zhao‐Chong; Tang, Zhao–You; Fan, Jia; Zhou, Jian; Zeng, Mengsu; Bi, Aihong; Tan, Yaohong

doi:10.1016/j.ijrobp.2009.01.057

Cited by 31 publications

(25 citation statements)

References 26 publications

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“…Wang et al (13) reported that GTV-to-CTV expansions of 4 mm for HCC are required to conceal any microinvasion and that this value could be reduced to 2 mm for about 95% patients with tumor dimensions #5 cm or AFP levels <400 mg/L. In past studies, CTV for IHC was defined as the GTV plus a margin of liver tissue that was $1 cm (6,(9)(10)(11) or 0.8 cm in length (12).…”

Section: Discussionmentioning

confidence: 99%

Impact Factors for Microinvasion in Intrahepatic Cholangiocarcinoma: A Possible System for Defining Clinical Target Volume

Zeng

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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Section: Discussionmentioning

confidence: 99%

Impact Factors for Microinvasion in Intrahepatic Cholangiocarcinoma: A Possible System for Defining Clinical Target Volume

Zeng

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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“…For patients with lymph node metastases, the lymph drainage area of the next station must be included in CTV. In other circumstances (e.g., confined to intrahepatic area, tumor emboli, adrenal metastases, pulmonary metastases), a 2- to 4-mm margin needs to be added around the GTV [103]. The magnitude of respiratory liver tumor motion can be evaluated using X-ray fluoroscopy; however, the four-dimensional (4D) CT simulation technique is more accurate.…”

Section: Treatmentmentioning

confidence: 99%

Guidelines for Diagnosis and Treatment of Primary Liver Cancer in China (2017 Edition)

Zhou¹,

Sun²,

Wang³

et al. 2018

Liver Cancer

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Background: Hepatocellular carcinoma (HCC) (about 85–90% of primary liver cancer) is particularly prevalent in China because of the high prevalence of chronic hepatitis B infection. HCC is the fourth most common malignancy and the third leading cause of tumor-related deaths in China. It poses a significant threat to the life and health of Chinese people. Summary: This guideline presents official recommendations of the National Health and Family Planning Commission of the People’s Republic of China on the surveillance, diagnosis, staging, and treatment of HCC occurring in China. The guideline was written by more than 50 experts in the field of HCC in China (including liver surgeons, medical oncologists, hepatologists, interventional radiologists, and diagnostic radiologists) on the basis of recent evidence and expert opinions, balance of benefits and harms, cost-benefit strategies, and other clinical considerations. Key Messages: The guideline presents the Chinese staging system, and recommendations regarding patients with HCC in China to ensure optimum patient outcomes.

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“…In SBRT, gross tumor volume, clinical target volume, internal target volume, and planning target volume are stipulated by ICRU Report 62 [21]. Although subclinical extension of HCC is a known phenomenon [22], clinical target volume margin is generally not critical in SBRT, because falloff exposure will likely eradicate any existing microscopic disease. If respiratory gating is applied, internal target volume is the sum of all gross tumor volumes within the predefined gating window.…”

Section: Sbrt Techniquementioning

confidence: 99%

Consensus on Stereotactic Body Radiation Therapy for Small-Sized Hepatocellular Carcinoma at the 7th Asia-Pacific Primary Liver Cancer Expert Meeting

et al. 2017

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Background: Stereotactic body radiation therapy (SBRT) is an advanced technique of external beam radiation therapy that delivers large ablative doses of radiation. In the past decade, many cancer centers have adopted SBRT as one mode of radically treating small-sized hepatocellular carcinoma (HCC), based on encouraging clinical outcomes. SBRT thus seems reasonable as first-line treatment of inoperable HCC confined to the liver. However, most of the clinical studies to date have been retrospective in nature, with key issues still under investigation. Summary: The above-mentioned publications were subjected to scrutiny, fueling discussions at the 7th Asia-Pacific Primary Liver Cancer Expert (APPLE 2016) Meeting on various clinical variables, such as indications for SBRT, therapeutic outcomes, treatment-related toxicities, doses prescribed, and specific techniques. The consensus reached should be of interest to all professionals active in the treatment of HCC, especially radiation oncologists. Key Messages: SBRT is a safe and effective therapeutic option for patients with small-sized HCC, offering substantial local control, improved overall survival, and low toxicity.

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Impact Factors for Microinvasion in Patients With Hepatocellular Carcinoma: Possible Application to the Definition of Clinical Tumor Volume

Cited by 31 publications

References 26 publications

Impact Factors for Microinvasion in Intrahepatic Cholangiocarcinoma: A Possible System for Defining Clinical Target Volume

Impact Factors for Microinvasion in Intrahepatic Cholangiocarcinoma: A Possible System for Defining Clinical Target Volume

Guidelines for Diagnosis and Treatment of Primary Liver Cancer in China (2017 Edition)

Consensus on Stereotactic Body Radiation Therapy for Small-Sized Hepatocellular Carcinoma at the 7th Asia-Pacific Primary Liver Cancer Expert Meeting

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