Impact de l’HPV (Human Papilloma Virus) dans les carcinomes autres que gynécologiques

Badoual, Cécile; Tartour, Éric; Roussel, H.; Bats, Anne-Sophie; Pavie, Juliette; Pernot, Simon; Weiss, Laurence; Mohamed, Ali Si; Thariat, Juliette; Hoffmann, C.; Péré, Hélène

doi:10.1016/j.revmed.2015.01.003

Cited by 5 publications

(11 citation statements)

References 68 publications

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“…Among the papers focusing on oropharyngeal SCC, the majority reported higher stromal or intraepithelial CD8+ T cell infiltration in HPV+ than in HPV− SCC [36,37,38,40,43,45,46,47,51]. Only Wansom et al did not find significant differences between these two types [34]. These results are relatively similar to those of studies that investigated HNSCC.…”

Section: Resultssupporting

confidence: 54%

“…Of the papers that investigated several different immune cell categories, some focused on oropharyngeal SCCs, whereas others focused on HNSCCs, including oropharyngeal and other anatomical localizations. The studies are shown in Table 3, Table 4, Table 5 and Table 6 [12,15,24,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64].…”

Section: Resultsmentioning

confidence: 99%

“…A total of 10 and 5 studies addressed CD8+ and CD4+ T lymphocytes (Table 3) [34,36,37,38,40,41,43,45,47,51]. Seven studies focused on regulatory T cells (Tregs) (Table 4) [34,36,38,43,45,53,54], and 5 focused on macrophages (Table 5) [34,56,58,59,60]. No studies addressed myeloid-derived suppressor cells (MDSCs) or Langerhans cells (LCs).…”

Section: Resultsmentioning

confidence: 99%

“…A high level of CD8+ T cell infiltration was associated with improved OS and RFS in all studies focusing on HPV+ oropharyngeal SCC [34,36,37,40,41,51]. Moreover, Ward et al found that patients with HPV+ oropharyngeal SCC with low levels of tumor-infiltrating lymphocytes had the same prognosis as those with HPV− oropharyngeal SCC [41].…”

Section: Resultsmentioning

confidence: 99%

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Impact of HPV Infection on the Immune System in Oropharyngeal and Non-Oropharyngeal Squamous Cell Carcinoma: A Systematic Review

Lechien

Seminerio

Descamps

et al. 2019

Cells

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Objectives: To review the current knowledge regarding the involvement of human papilloma virus (HPV) infection and the immune system in the development of head and neck squamous cell carcinoma (HNSCC). Methods: An electronic literature search was conducted to identify articles published between 1990 and 2019 pertaining to tumor-infiltrating immune cells (TICs) in HNSCC using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Issues of clinical relevance, including tumor location, the number of tumor samples, the inclusion of additional specimens (dysplastic or normal mucosa), tumor size, methods used for HPV detection, relationship between antigen expression and patient characteristics (age, gender, smoking, alcohol consumption, etc.), and prognostic data (overall survival (OS) and recurrence-free survival (RFS)) were assessed by four blinded investigators. Results: The search identified 335 relevant studies, of which 41 met the inclusion criteria. Of these, 7 studies focused on the peripheral blood immune cell concentration in patients with HNSCC according to HPV status, and 36 studies investigated TICs in the intraepithelial and/or stromal compartment(s) according to HPV status. The immune cells studied were CD8+ T cells (N = 19), CD4+ T cells (N = 7), regulatory T cells (Tregs, N = 15), macrophages (N = 13), myeloid-derived suppressor cells (MDSCs, N = 4), and Langerhans cells (LCs, N = 2). Conclusions: Irrespective of tumor location, CD8+ and CD4+ T cells appear to play a key role in the development of HPV−related HNSCC, and their infiltration is likely associated with a significant impact on OS and RFS. To date, the roles and prognostic value of Tregs, macrophages, DCs and MDSCs remain unclear.

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Section: Resultssupporting

confidence: 54%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Impact of HPV Infection on the Immune System in Oropharyngeal and Non-Oropharyngeal Squamous Cell Carcinoma: A Systematic Review

Lechien

Seminerio

Descamps

et al. 2019

Cells

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“…HPV is well established as a causal factor in other cancers such as cervical and head and neck cancers. In addition, high-risk HPVs have been identified in a wide range of other cancers and non-cancerous tissues ( 44 ). In the past, HPVs have been regarded as being specific to epithelial cells including breast epithelial cells.…”

Section: Introductionmentioning

confidence: 99%

Human Papilloma Viruses and Breast Cancer – Assessment of Causality

2016

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High risk human papilloma viruses (HPVs) may have a causal role in some breast cancers. Case–control studies, conducted in many different countries, consistently indicate that HPVs are more frequently present in breast cancers as compared to benign breast and normal breast controls (odds ratio 4.02). The assessment of causality of HPVs in breast cancer is difficult because (i) the HPV viral load is extremely low, (ii) HPV infections are common but HPV associated breast cancers are uncommon, and (iii) HPV infections may precede the development of breast and other cancers by years or even decades. Further, HPV oncogenesis can be indirect. Despite these difficulties, the emergence of new evidence has made the assessment of HPV causality, in breast cancer, a practical proposition. With one exception, the evidence meets all the conventional criteria for a causal role of HPVs in breast cancer. The exception is “specificity.” HPVs are ubiquitous, which is the exact opposite of specificity. An additional reservation is that the prevalence of breast cancer is not increased in immunocompromised patients as is the case with respect to HPV-associated cervical cancer. This indicates that HPVs may have an indirect causal influence in breast cancer. Based on the overall evidence, high-risk HPVs may have a causal role in some breast cancers.

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Human Papillomavirus and students in Brazil: an assessment of knowledge of a common infection – preliminary report

Burlamaqui

Cassanti

Borim

et al. 2017

Brazilian Journal of Otorhinolaryngology

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Impact de l’HPV (Human Papilloma Virus) dans les carcinomes autres que gynécologiques

Cited by 5 publications

References 68 publications

Impact of HPV Infection on the Immune System in Oropharyngeal and Non-Oropharyngeal Squamous Cell Carcinoma: A Systematic Review

Impact of HPV Infection on the Immune System in Oropharyngeal and Non-Oropharyngeal Squamous Cell Carcinoma: A Systematic Review

Human Papilloma Viruses and Breast Cancer – Assessment of Causality

Human Papillomavirus and students in Brazil: an assessment of knowledge of a common infection – preliminary report

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