Impact assessment of emission management strategies of the pharmaceuticals Metformin and Metoprolol to the aquatic environment using Bayesian networks

Brandmayr, Caterina; Kerber, Heide; Winker, Martina; Schramm, Engelbert

doi:10.1016/j.scitotenv.2015.05.074

Cited by 11 publications

(4 citation statements)

References 41 publications

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“…The sensitivity analysis presents the variance reduction and the percentage of variance reduction for each of the input nodes. Moreover, in order to provide a clearer comparison of the relative sensitivity, a normalised variance reduction was calculated by dividing the percent variance reduction of each node by the highest percent variance reduction (Brandmayr, Kerber, Winker, & Schramm, 2015). Variance of beliefs indicates the uncertainty of these estimations (Cinicioglu, Önsel, & Ülengin, 2012).…”

Section: Sensitivity Analysismentioning

confidence: 99%

Bayesian network revealing pathways to workplace innovation and career satisfaction in the public service

Wipulanusat

Panuwatwanich

Stewart

et al. 2020

Journal of Management Analytics

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This paper examined the innovation process in the Australian Public Service (APS) using a Bayesian network (BN) founded on an empirically derived structural equation model.The focus of the BN was to examine the impact of leadership style and organisational culture on workplace innovation and career satisfaction in the APS. Using scenario analysis, the best combination of managerial actions for enhancing APS career satisfaction was determined. The results emphasise the benefit of encouraging management to adopt a transformational leadership style and instilling innovative culture in their organisation. In addition, innovative culture was a key driver of workplace innovation, which served to improve the career satisfaction of APS employees.Implications are discussed to propose practical strategies for organisations wish to encourage innovation among employees.

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Section: Sensitivity Analysismentioning

confidence: 99%

Bayesian network revealing pathways to workplace innovation and career satisfaction in the public service

Wipulanusat

Panuwatwanich

Stewart

et al. 2020

Journal of Management Analytics

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“…This means that as a part of precautionary measures, the "human health care" provisioning system needs to be readjusted. If possible, the consumption of pharmaceuticals should be reduced, and supported by measures such as different prescribing practices and disease prevention, proper handling of pharmaceuticals, and the development of environmentally friendly pharmaceuticals [43].…”

Section: Risks As Side-effects Of Normal Operationmentioning

confidence: 99%

“…If the dynamics in coupled systems are not sufficiently addressed, risk management approaches will remain one-dimensional and will only deal with the symptoms (cf. [43,73]). But a "multifunctional" perspective, as described in the case of forest management, can make it possible to identify risks for other, linked provisioning systems [80].…”

Section: Forest Managementmentioning

confidence: 99%

“…Table 1 gives an overview of risk management strategies frequently applied to the cases outlined in this article, and their extension through an integrated, social-ecological perspective. Integrative sustainability policies [43] including  a transformation of the health care system (improved doctor-patient communication, preventive measures to reduce the prevalence of risk factors related to certain diseases, etc.)  encouragement for the introduction of environmentally friendly pharmaceuticals  measures in the area of environmental engineering…”

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confidence: 99%

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More Than a Potential Hazard—Approaching Risks from a Social-Ecological Perspective

et al. 2017

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Risks have been classically understood as a probability of damage or a potential hazard resulting in appropriate management strategies. However, research on environmental issues such as pollutants in the aquatic environment or the impacts of climate change have shown that classical management approaches do not sufficiently cover these interactions between society and nature. There have been several attempts to develop interdisciplinary approaches to risk that include natural as well as social science contributions. In this paper, the authors aim at developing a social-ecological perspective on risk by drawing on the concept of societal relations to nature and the model of provisioning systems. This perspective is used to analyze four cases, pharmaceuticals, microplastics, semicentralized water infrastructures and forest management, with regard to risk identification, assessment and management. Finally, the paper aims at developing a perspective on risks which takes into account non-intended side-effects, system interdependencies and uncertainty.

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Toxicity Risks Associated With the Beta‐Blocker Metoprolol in Marine and Freshwater Organisms: A Review

Love,

Slovisky,

Costa

et al. 2024

Enviro Toxic and Chemistry

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The detection of pharmaceuticals in aquatic ecosystems has generated concern for wildlife and human health over the past several decades. β‐adrenergic blocking agents are a class of drugs designed to treat cardiovascular diseases and high blood pressure. Metoprolol is a second‐generation β1‐adrenergic receptor inhibitor detected in effluent derived from sewage treatment plants. Our review presents an updated survey of the current state of knowledge regarding the sources, occurrence, and toxicity of metoprolol in aquatic ecosystems. We further aimed to summarize the current literature on the presence of metoprolol in various classes of aquatic species and to consider the trophic transfer of these contaminants in marine mammals. The biological impacts of metoprolol have been reported in 20 aquatic organisms, with a primary focus on cardiac function and oxidative stress. Our review reveals that concentrations of metoprolol that cause toxicity in aquatic species are above levels that are typical of marine and freshwater environments. Future studies should investigate the effects of metoprolol at lower concentrations in aquatic organisms. Other recommendations include (1) a further focus on noncardiac endpoints, because computational assessments of currently available molecular data identify gonadotropins, vitellogenin, collagen, and cytokines as potential targets of modulation, and (2) development of adverse outcome pathways for cardiac dysfunction in aquatic species to improve our understanding of molecular interactions and outcomes following exposure. As the next generation of β‐blockers is developed, continued diligence is needed for assessing environmental impacts in aquatic ecosystems to determine their potential accumulation and long‐term effects on wildlife and humans. Environ Toxicol Chem 2024;00:1–14. © 2024 SETAC

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Impact assessment of emission management strategies of the pharmaceuticals Metformin and Metoprolol to the aquatic environment using Bayesian networks

Cited by 11 publications

References 41 publications

Bayesian network revealing pathways to workplace innovation and career satisfaction in the public service

Bayesian network revealing pathways to workplace innovation and career satisfaction in the public service

More Than a Potential Hazard—Approaching Risks from a Social-Ecological Perspective

Toxicity Risks Associated With the Beta‐Blocker Metoprolol in Marine and Freshwater Organisms: A Review

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