IMP3 Is a Novel Prognostic Marker that Correlates with Colon Cancer Progression and Pathogenesis

Li, Dawei; Yan, Dongwang; Tang, Huamei; Zhou, Chongzhi; Fan, Junwei; Li, Shuxia; Wang, Xiaoliang; Xia, Jun; Huang, Fei; Qiu, Guoqiang; Peng, Zhihai

doi:10.1245/s10434-009-0648-5

Cited by 97 publications

(95 citation statements)

References 27 publications

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“…10,25 Specifically, increased protein expression of IGF2BP3 has been associated with enhanced tumor aggressiveness, metastatic behavior and inferior outcome of various solid cancers. [12][13][14][15][16][17][18] Recently, there has been growing interest in the IGF pathway from a therapeutic perspective, as monoclonal antibodies and small molecules targeting the IGF1 receptor have become available a few years ago and initial, small phase I and II, trials showed encouraging results in individual patients. 25 In this study, we investigated the mRNA expression levels of several molecules involved in IFG signaling in mantle cell lymphoma cell lines and primary mantle cell lymphoma cases.…”

Section: Discussionmentioning

confidence: 99%

“…Originally, IGF2BP3 was found to be overexpressed in pancreatic cancer. 11 More recently, increased IGF2BP3 protein expression has been reported in a variety of solid tumors and was found to be associated with a higher histological grade, 12 progression or metastasis 13,14 and with an unfavorable outcome. [15][16][17][18] These data indicate that IGF2BP3 may promote tumor cell proliferation and progression by enhancing signaling via the IGF pathway.…”

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Increased tumor cell proliferation in mantle cell lymphoma is associated with elevated insulin-like growth factor 2 mRNA-binding protein 3 expression

et al. 2012

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Mantle cell lymphoma is an aggressive, non-curable B-cell lymphoma, characterized by the translocation t(11;14)(q13;q32) involving CCND1 and a high number of additional genetic alterations. Chromosomal gains of 7p are frequent in mantle cell lymphoma, with insulin-like growth factor II mRNA-binding protein 3 (IGF2BP3 aka IMP3) being the most upregulated gene in this region. IGF2BP3 is a member of the IGF II mRNA-BP family, and increased IGF2BP3 expression is associated with an aggressive behavior in many malignant tumors. We here analyze selected genes related to IGF signaling in gene expression and genomic array data of 8 mantle cell lymphoma cell lines and 12 primary mantle cell lymphomas and study IGF2BP3 protein expression in 172 wellcharacterized primary mantle cell lymphomas by immunohistochemistry. The majority of mantle cell lymphoma cell lines and primary cases showed elevated IGF2BP3 mRNA expression and a subset also expressed the IGF1 and IGF2 receptors. On the protein level, 66 of 172 primary mantle cell lymphomas showed IGF2BP3 expression in 450% of tumor cells, and strong IGF2BP3 protein expression was highly associated with increased proliferation as measured by the Ki-67 index, but not with overall survival of mantle cell lymphoma patients. Only a subset of mantle cell lymphomas with marked IGF2BP3 expression had an underlying chromosomal gain in 7p, suggesting that additional mechanisms are involved in the upregulation of IGF2BP3 in mantle cell lymphoma. In seven paired mantle cell lymphoma samples, IGF2BP3 protein expression remained constant between primary diagnosis and relapse. Increased IGF2BP3 expression and, potentially, enhanced IGF signaling may contribute proproliferative stimuli in the evolution of mantle cell lymphoma tumor cells.

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Section: Discussionmentioning

confidence: 99%

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Increased tumor cell proliferation in mantle cell lymphoma is associated with elevated insulin-like growth factor 2 mRNA-binding protein 3 expression

et al. 2012

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“…It has been reported that IGF2BP3 is a prognostic and diagnostic biomarker in many tumoral tissues including colorectal adenocarcinoma (22)(23)(24)(25). We stained 112 formalin fixed paraffin embedded colorectal tumor tissues (NOS type) with an immunohistochemistry method and showed that 50% of these tumors were cytoplasmically positive for IMP3.…”

Section: Discussionmentioning

confidence: 97%

The Relationship Between IMP3 Expression in Colorectal Adenocarcinoma and Clinicopathologic Findings

Radfar¹,

Achak²,

Rajaei³

2015

Biotech Health Sci

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Background:The IMP3 is an oncofetal protein, which has been recently proposed as a diagnostic and prognostic marker in many cancers, including colorectal adenocarcinoma. The overexpression of IMP3 seems to have a correlation with patient's prognosis. Objectives: In this study, the relationship between IMP3 expression in colorectal adenocarcinoma and clinicopathologic findings was assessed. Patients and Methods:In this study 112 colorectal tumor paraffin blocks of Rasoul-e-Akram hospital were stained for IMP3 and slides were assessed for intensity and extent of positivity. The statistical relationships between marker expression and clinicopathologic findings (degree of differentiation, tumor size, depth of invasion and lymph nodes metastasis) were assessed. Data were analyzed by the SPSS 21 software and logistic regression and chi-square test, with p-values of less than 0.05 indicating statistical significance. Results: Immunoreactivity pattern of IMP3 was cytoplasmic in different clinicopathologic findings. Among different clinicopathologic findings, we found a statistical relationship between tumor differentiation and IMP3 (P = 0.047); so that, the poorly differentiated tumors were positive for this marker. No relationship was found between tumor size, depth of invasion or lymph node involvement and IMP3. Conclusions: IMP3 immunoreactivity was associated with poor differentiation of tumor yet not associated with tumor size depth of invasion or lymph node involvement.

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“…It is postulated that IMP3 is expressed at low or undetectable levels in mature tissues, except for the placenta (8). However, the expression of IMP3 was reported in tumors of many organs such as the kidney (13), liver (14), endometrium (15), cervix (16), ovary (17), breast (18)(19), pancreas (20), stomach (21), colon (22), bladder (23), and lung (24), as well as in malignant melanoma (25) and some sarcomas (26)(27). Since IMP3 is detected in fetal and neonatal tissues and various tumors, it is considered an oncofetal protein.…”

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confidence: 99%

Imp3 Expression in Benign and Malignant Thyroid Tumors and Hyperplastic Nodules

Kulaçoğlu¹,

Erkılınç²

2015

Balkan Med J

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Background: IMP3, a member of insulin-like growth factor II m RNA binding protein family, seems to be promising in the diagnosis of carcinomas of many organs as well as malignant melanomas and some sarcomas. It is postulated that it might be a marker of malignancy. The results of the few prior studies indicate that IMP3 has the potential to be useful in distinguishing benign and malignant tumors of thyroid. Aims: We aimed to evaluate the immunohistochemical expression of IMP3 in non-neoplastic nodules and benign and malignant tumors of the thyroid. Study Design: Diagnostic accuracy study. Methods: Overall, 92 thyroid lesions, including 22 nodular hyperplasia (NH), 14 follicular adenoma (FA), 9 follicular carcinoma (FC), 37 papillary carcinoma (PC) (15 follicular variant), 3 well differentiated carcinoma-not otherwise specified (WDC-NOS), 4 poorly differentiated carcinoma (PDC) and anaplastic carcinoma (AC) were included. Immunohistochemically, cytoplasmic expression of IMP3 was evaluated in terms of extent and intensity of the staining semi-quantitatively and an immunohistochemical score (IHS) was obtained for each case. A score higher than 2 was considered positive staining. Results: In contrast with previous studies, we observed positive staining in benign lesions, especially in benign tumors. For identifying malignant tumors, the sensitivity of IMP3 was 82.1%, specificity was 33.3%, positive predictive value (PPV) was 65.7% and negative predictive value (NPV) was 54.5%. In distinguishing neoplastic and hyperplastic lesions, the sensitivity was 50%, specificity was 15.7%, PPV was 15.7% and NPV was 50%. The IMP3 expression was similar for FA and well differentiated carcinomas (p=0.434), but there was a significant difference between hyperplastic nodules and FA (p=0.011). Conclusion: Our data suggest that IMP3 is effective in discriminating hyperplastic and neoplastic lesions but not useful in differentiating benign tumors from malignant tumors.

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IMP3 Is a Novel Prognostic Marker that Correlates with Colon Cancer Progression and Pathogenesis

Abstract: IMP3 may play an important role in colon cancer progression and could serve as a prognostic biomarker to identify patients at risk of developing metastasis or recurrence after colonectomy.

Cited by 97 publications

References 27 publications

Increased tumor cell proliferation in mantle cell lymphoma is associated with elevated insulin-like growth factor 2 mRNA-binding protein 3 expression

Increased tumor cell proliferation in mantle cell lymphoma is associated with elevated insulin-like growth factor 2 mRNA-binding protein 3 expression

The Relationship Between IMP3 Expression in Colorectal Adenocarcinoma and Clinicopathologic Findings

Imp3 Expression in Benign and Malignant Thyroid Tumors and Hyperplastic Nodules

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