IMP3 as a cytoplasmic biomarker for early serous tubal carcinogenesis

Wang, Yiying; Li, Lingmin; Wang, Yue; Yuan, Zeng; Zhang, Wenjing; Hatch, Kenneth D.; Zheng, Wenxin

doi:10.1186/preaccept-1744854612129169

Cited by 3 publications

(3 citation statements)

References 26 publications

(37 reference statements)

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“…The explanation for such a wide range of IMP3 expression in the various studies is not clear but could be related to the different cut-offs for positivity used. Two studies used 10% of positive tumor cells as a cut off [8,26], while the remaining studies used different scoring systems, mostly taking into account staining intensity as well as percentage of positive tumor cells [24,27,29,30].…”

Section: Discussionmentioning

confidence: 99%

A comprehensive immunohistochemical analysis of IMP2 and IMP3 in 542 cases of ovarian tumors

et al. 2023

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Background IMP2 and IMP3 are mRNA binding proteins involved in carcinogenesis. We examined a large cohort of ovarian tumors with the aim to assess the value of IMP2 and IMP3 for differential diagnosis, and to assess their prognostic significance. Methods Immunohistochemical analyses with antibodies against IMP2 and IMP3 were performed on 554 primary ovarian tumors including 114 high grade serous carcinomas, 100 low grade serous carcinomas, 124 clear cell carcinomas, 54 endometrioid carcinomas, 34 mucinous carcinomas, 75 mucinous borderline tumors, and 41 serous borderline tumors (micropapillary variant). The associations of overall positivity with clinicopathological characteristics were evaluated using the chi-squared test or Fisher’s Exact test. Results We found IMP2 expression (in more than 5% of tumor cells) in nearly all cases of all tumor types, so the prognostic meaning could not be analyzed. The positive IMP3 expression (in more than 5% of tumor cells) was most common in mucinous carcinomas (82%) and mucinous borderline tumors (81%), followed by high grade serous (67%) and clear cell carcinomas (67%). The expression was less frequent in endometrioid carcinomas (39%), low grade serous carcinomas (23%), and micropapillary variant of serous borderline tumors (20%). Prognostic significance of IMP3 could be evaluated only in low grade serous carcinomas in the case of relapse-free survival, where negative cases showed better RFS (p = 0.033). Conclusion Concerning differential diagnosis our results imply that despite the differences in expression in the different ovarian tumor types, the practical value for diagnostic purposes is limited. Contrary to other solid tumors, we did not find prognostic significance of IMP3 in ovarian cancer, with the exception of RFS in low grade serous carcinomas. However, the high expression of IMP2 and IMP3 could be of predictive value in ovarian carcinomas since IMP proteins are potential therapeutical targets.

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Section: Discussionmentioning

confidence: 99%

A comprehensive immunohistochemical analysis of IMP2 and IMP3 in 542 cases of ovarian tumors

et al. 2023

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“…Overexpression of IMP3 is observed in a series of human malignancies, including ovarian, endometrial, and cervical cancers [ 26 – 28 ]. Our prior study showed that IMP3 may serve as a complimentary biomarker in diagnosing STIC and overexpression of IMP3 in tubal epithelia increases the risk of ovarian serous cancer development [ 29 , 30 ]. It will be of great interest to examine if tubal cytology in combination with biomarker studies may increase the sensitivity and specificity of detecting serous cancer of tubal origin.…”

Section: Discussionmentioning

confidence: 99%

Cytologic studies of the fallopian tube in patients undergoing salpingo-oophorectomy

et al. 2016

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BackgroundMounting evidence suggests the fallopian tube as the origin for ovarian high grade serous carcinoma (HGSC). We attempted to identify the tubal cytological features that allow us to distinguish malignant from benign conditions.MethodsTubal specimens (n = 56) were collected from patients who underwent bilateral salpingo-oophorectomy (BSO) due to various clinical indications. A standard procedure to collect fallopian tube brushings from freshly received surgical specimens was developed. Cytological diagnoses were classified into three categories: benign, atypical, and suspicious for malignancy/malignant. Cytological variables of individual cells and epithelia were subjected to statistical analysis. The fallopian tube histology was used as diagnostic reference for confirmation of cytology diagnosis.ResultsAmong the 56 fallopian tube specimens, 2 (3.7 %) showed inadequate cellularity preventing further evaluation, 11 (20.4 %) were diagnosed as malignant or suspicious of malignancy, 7 were atypical, and 36 were benign. The presence of three dimensional clusters (p < 0.0001, Fisher’s Exact Test), or prominent nucleoli (p = 0.0252, Fisher Exact test) was highly correlated with the diagnosis of malignancy. The suspicious malignant/malignant cytological diagnosis was also highly correlated with presence of HGSC with or without serous tubal intraepithelial carcinoma (STIC).ConclusionsTubal cytology may be useful for ovarian cancer screening and early detection.

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“…Hence, the overexpression of IMP3 which is normally not expressed in normal adult tissue may be involved in the initial process of tubal or pelvic serous carcinogenesis and IMP3 signature may serve as a hidden preneoplastic biomarker for these tumors in women. [11] SCOUTs forming a morphologically distinct stretch of the secretory cell population have been linked to serous neoplasia and serve as a biomarker. [12] STICs called also as tubal lesions in transition are noninvasive carcinomas recognized in the fallopian tube.…”

Section: Introductionmentioning

confidence: 99%