Immunotropic aspect of the <i>Bacillus coagulans</i> probiotic action

Bomko, Tatyana; Nosalskaya, Tatiana Nikolaevna; Kabluchko, Tatiana; Lisnyak, Yury V; Martynov, Artur

doi:10.1111/jphp.12726

Cited by 21 publications

(10 citation statements)

References 24 publications

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“…B. coagulans as a spore forming bacterium is one of the most promising probiotic bacteria, but still some of its pharmacological aspects have not been clarified yet (7). This bacterium can tolerate the acidic conditions of the stomach until it reaches the intestine and germinates there.…”

Section: Introductionmentioning

confidence: 99%

The effect of Bacillus coagulans on cytotoxicity and apoptosis induced by Salmonella Typhimurium in HT-29 cell culture

Kawarizadeh

Nojoomi

Tabatabaei

et al. 2019

IJM

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Background and Objectives: Human epithelial cells have been widely used to study the interaction between intestinal cells and pathogens, in vitro. In this study, the effect of probiotic bacteria Bacillus coagulans and its supernatant on the growth inhibition, cytotoxicity and induction of apoptosis caused by Salmonella Typhimurium and its adhesion to HT-29 cells were investigated. Materials and Methods: B. coagulans supernatant was used to obtain the minimum inhibitory concentration. To evaluate the cytotoxicity and percent of apoptotic cells, B. coagulans and its supernatant (2, 4, 6 and 8% concentrations) with S. Typhimurium was added to HT-29 cells. The MTT assay was used in order to evaluate the cytotoxicity. Percent of apoptotic cells was reported using a fluorescence staining method. Additionally, the adhesion of S. Typhimurium to HT-29 cells was investigated. The effect of B. coagulans on the level of adhesion was also studied. Results: The most inhibitory effect was shown at the concentration of 80000 µg/ml supernatant of B. coagulans (54.77% ± 1.43). The simultaneous culture of S. Typhimurium with B. coagulans had the lowest amount of cytotoxicity and induced apoptosis among the all co-culture groups of S. Typhimurium with B. coagulans or its supernatant. The determined cytotoxicity and induced apoptosis were 26.06 % ± 3.79 and 17.63 % ± 2.14 respectively. In the adhesion test, it was observed that B. coagulans can significantly prevent adhesion of S. Typhimurium to HT-29 cell. Conclusion: B. coagulans can reduce the adhesion, cytotoxicity and induction of apoptosis caused by S. Typhimurium in HT-29 cells in vitro.

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Section: Introductionmentioning

confidence: 99%

The effect of Bacillus coagulans on cytotoxicity and apoptosis induced by Salmonella Typhimurium in HT-29 cell culture

Kawarizadeh

Nojoomi

Tabatabaei

et al. 2019

IJM

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“…Oral supplementation with A. muciniphila after FMT with nonresponder feces restored the efficacy of PD-1 blockade (Routy et al, 2018). Bacillus coagulans were proved to improve chronic colitis, enhance immunity, inhibit enteropathogenic bacteria, and repair the intestinal mucosa (Bomko et al, 2017). The treatment with Bacillus coagulans and the prebiotic inulin significantly inhibits serum amyloid A protein in arthritic rats and promotes a significant TNF release decrease (de Oliveira, 2019).…”

Section: Discussionmentioning

confidence: 99%

Sini Decoction Ameliorates Colorectal Cancer and Modulates the Composition of Gut Microbiota in Mice

Wang

Zhang

et al. 2021

Front. Pharmacol.

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Sini Decoction (SND), as a classic prescription of Traditional Chinese Medicine (TCM), has been proved to be clinically useful in cardiomyopathy and inflammatory bowel diseases. However, the role and mechanism of SND in colitis-associated cancer remains unclear. This study aims to evaluate the effect of SND on colorectal cancer(CRC) symptoms and further explore the changes of gut microbes mediated by SND extract in azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mice through 16 S rRNA sequencing. Our results indicated that treatment with SND extract could ameliorate the tumors' malignant degree by decreasing tumor number and size. Also, the expression levels of Cyclooxygenase 2 and Mucin-2, which are typical CRC biomarkers, were reduced compared to the CRC group. In the meantime, SND extract can upregulate CD8+ T lymphocytes' expression and Occludin in the colonic mucosal layer. Besides, SND inhibited the expression of CD4+ T cells and inflammatory cytokines in CRC tissue. According to bioinformatics analysis, SND extract was also suggested could modulate the gut microbial community. After the SND treatment, compared with the CRC mice model, the number of pathogenic bacteria showed a significant reduction, including Bacteroides fragilis and Sulphate-reducing bacteria; and SND increased the relative contents of the beneficial bacteria, including Lactobacillus, Bacillus coagulans, Akkermansia muciniphila, and Bifidobacterium. In summary, SND can effectively intervene in colorectal cancer development by regulating intestinal immunity, protecting the colonic mucosal barrier, and SND can change the intestinal microbiota composition in mice.

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“…Furthermore, in the study of S. Zhao et al Bacillus coagulans 13002 can promote the recovery of serum immune protein and immune factor levels in immunosuppressed mice fed cyclophosphamide (Zhao et al 2021). It has also been reported in the literature that mice that ingested streptomycin with cyclophosphamide to suppress organism immunity caused intestinal dysfunction, and the data showed that Bacillus coagulans had a significant ameliorating effect, with a 75% decrease in diarrheal symptoms and a return to normal gastrointestinal function, which was better than the ingestion of products containing Lactobacilli and Bifidobacteria (Bomko et al 2017). Furthermore, Bacillus coagulans also plays a regulatory role in promoting the body to revive health in chronic immune diseases.…”

Section: The Immune Regulationmentioning

confidence: 96%

Application of Weizmannia coagulans in the medical and livestock industry

Wang

et al. 2022

Ann Microbiol

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Purpose Products enriched with probiotics have always been fashionable. Weizmannia coagulans has become a hot research topic in the academic community due to their multiple functional properties and high resistance to stress, which can retain their activity in a variety of harsh environments. This review aims to evaluate the probiotic effects of different strains of Weizmannia coagulans in animals and humans and to inspire better exploitation of the value of this strain. Methods This review summarizes the latest research progress of Weizmannia coagulans from two major applications in animal breeding and human health. Results The functional properties of Weizmannia coagulans are extensively recognized. In animals, the strain can promote nutrient absorption, reduce mortality, and enhance the slaughter rate in livestock and poultry. In humans, the strain can be used to treat gastrointestinal disorders, immunomodulation, depressive symptoms, and non-alcoholic fatty liver. Weizmannia coagulans is projected as an ideal substitute for antibiotics and other chemical drugs. Conclusion Despite the outstanding functional properties of Weizmannia coagulans, there are numerous strains of Weizmannia coagulans and significant differences between strains in functional and physiological properties. Currently, there are few literature reports on the probiotic mechanism and functional gene identification of Weizmannia coagulans, which is crucial for the commercialization of Weizmannia coagulans and the benefit of human society.

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Immunotropic aspect of the Bacillus coagulans probiotic action

Abstract: According to all parameters, B. coagulans has been proved to be more effective as compared to the Linex Forte reference product containing lacto- and bifidobacteria.

Cited by 21 publications

References 24 publications

The effect of Bacillus coagulans on cytotoxicity and apoptosis induced by Salmonella Typhimurium in HT-29 cell culture

The effect of Bacillus coagulans on cytotoxicity and apoptosis induced by Salmonella Typhimurium in HT-29 cell culture

Sini Decoction Ameliorates Colorectal Cancer and Modulates the Composition of Gut Microbiota in Mice

Application of Weizmannia coagulans in the medical and livestock industry

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