Immunotoxicity of aminocarb. III. Exposure route-dependent immunomodulation by aminocarb in mice

A T-cell-dependent humoral immune response is preserved during the administration of the nerve agent pre-treatment pyridostigmine bromide in a murine model

“…Aminocarb increased PFC number following oral administration but appeared immunosuppressive following i.p. administration [32] and carbaryl was immunosuppressive following inhalation exposure but was ineffective by oral or dermal exposure [33]. The results of these studies clearly have important consequences for interpretation of the results presented here and suggest that careful consideration of dosing route should be made in planning future studies and in the interpretation of previous studies where different dosing routes are used.…”

Evaluation of immunotoxicity induced by propoxure in C57Bl/6 mice

“…root of exposure was used in our experiments. Other carbamate insecticides and chemicals such as aldicarb [5], aminocarb [6], and ethyl-carbamate [4] have shown immunotoxic properties in relevant subchronic doses. In scanty immunotoxicology studies conducted on PPX in rat model, PPX has shown immunosuppressive effects [10].…”

Immunotoxicity of Pesticides

“…In studies using a rat model, the route of exposure has been demonstrated to be important when analyzing carbaryl immunotoxicity. Bernier et al (1995) demonstrated that oral and dermal route exposure stimulated the humoral immune response while the intraperitoneal (i.p.) In mice, the route of exposure determines the effect aminocarb has on the immune system.…”