Immunotoxic and toxic evaluation of subchronic exposure to saxitoxin in rats.

Abstract

Forty male rats were equally divided into 4 groups and administered with saxitoxin (STX) at 0, 10, 30 and 90 µg/kg body weight by gavage for 28 days. Bone marrow, lymphocyte proliferation and histopathology of selected tissues were analysed after euthanasia. It was shown that body weight gain, food intake, lymphoid organ weights, lymphocyte proliferation, and histological analyses were not significantly different between groups.