Immunotherapy with the saponin enriched-Leishmune® vaccine versus immunochemotherapy in dogs with natural canine visceral leishmaniasis

Borja-Cabrera, G.P.; Santos, F.N.; Santos, Flávia Barreto dos; Trivellato, Fernando Antonio de A.; Kawasaki, Jarbas Kiyoshi A; Costa, Andreia Cerqueira; Castro, Tatiana; Nogueira, Fabiane; Moreira, M. A. B.; Luvizotto, Maria Cecília Rui; Palatnik, Marcos; Palatnik-de-Sousa, Clarisa B.

doi:10.1016/j.vaccine.2009.09.071

Cited by 56 publications

(55 citation statements)

References 50 publications

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“…These antigens were used in conjunction with saponin, an adjuvant that has been used in studies involving VL or cutaneous leishmaniasis in mice and dogs (Santos et al 2002, Nico et al 2007, Fernandes et al 2008, Borja-Cabrera et al 2010. We found that both vaccine candidates were able to reduce parasite load in the liver, but that only the L. amazonensis immunogenic extract reduced the parasite load of the spleen.…”

Section: Discussionmentioning

confidence: 69%

Antigenic extracts of Leishmania braziliensis and Leishmania amazonensis associated with saponin partially protects BALB/c mice against Leishmania chagasi infection by suppressing IL-10 and IL-4 production

Grenfell

Silva

Testasicca

et al. 2010

Mem. Inst. Oswaldo Cruz

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This study evaluated two vaccine candidates for their effectiveness in protecting BALB/c mice against Leishmania chagasiinfection. These immunogenic preparations were composed of Leishmania amazonensisor Leishmania braziliensisantigenic extracts in association with saponin adjuvant. Mice were given three subcutaneous doses of one of these vaccine candidates weekly for three weeks and four weeks later challenged with promastigotes of L. chagasiby intravenous injection. We observed that both vaccine candidates induced a significant reduction in the parasite load of the liver, while the L. amazonensisantigenic extract also stimulated a reduction in spleen parasite load. This protection was associated with a suppression of both interleukin (IL)-10 and IL-4 cytokines by spleen cells in response to L. chagasiantigen. No change was detected in the production of IFN-γ. Our data show that these immunogenic preparations reduce the type 2 immune response leading to the control of parasite replication

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Section: Discussionmentioning

confidence: 69%

Antigenic extracts of Leishmania braziliensis and Leishmania amazonensis associated with saponin partially protects BALB/c mice against Leishmania chagasi infection by suppressing IL-10 and IL-4 production

Grenfell

Silva

Testasicca

et al. 2010

Mem. Inst. Oswaldo Cruz

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“…From experimental studies, it has been known that these wild animals do not often reveal symptoms and experience frequent re-infections [1,16,17]. Such evidence helps us to assume that all individuals never die of the infection and acquire immunity, and thus, to adopt an susceptible-infectious-susceptible (SIS) model [18][19][20][21][22][23][24].…”

Section: Methodsmentioning

confidence: 99%

Examining the reservoir potential of animal species for $$\varvec{\textit{Leishmania infantum}}$$ Leishmania infantum infection

Fukami

Nishiura

2015

Japan J. Indust. Appl. Math.

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Leishamaniasis is a parasitic disease transmitted by sandfly Phlebotomus spp. and is seen in tropical and subtropical countries in which an estimated 12 million persons are infected. Among various types of leishmaniasis, zoonotic visceral leishmaniasis (ZVL) caused by Leishmania infantum is an important amphixenosis shared by human and other animals. Although identifying the natural reservoir host would help better understand the transmission dynamics of Leishmania spp., little effort has been made to quantitatively clarify the dynamics involving the reservoir host of ZVL. The present study investigated the reservoir potential of four wild animals in maintaining ZVL, using prevalence data from Latin American countries in Amazons and examining the role of crab-eating fox, spiny rat, common opossum and black rat in maintaining the transmission. Reflecting frequent reinfections, a susceptible-infectedsusceptible model was employed, enabling us to estimate model parameters from endemic prevalence data. The next generation matrix of the multi-host system was computed, permitting us to theoretically examine the reservoir potential of each animal species. Our estimates indicated that there is no unique reservoir host consisting of single animal species. Crab eating fox was considered to play an important role in maintaining L. infantum transmission, but this was the case only in combination with other hosts. The present study indicates that animal species other than canine play important roles in maintaining transmission of Leishmania infantum, which is different from conventional wisdom that centered on the importance of canine only. Greater sample size with additional entomological and genetic insights into inter-specific contact would be required to implement more explicit assessments.

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“…Οι εμβολιασμένοι σκύλοι γίνονται ορολογικά θετικοί, αλλά μπορούν να διαφοροποιηθούν από τους φυσικά μολυσμένους με την κυτταρομετρία ροής (de Andrade et al 2007). Το εμβόλιο αυτό έχει χρησιμο ποιηθεί και σε ασθενείς σκύλους, σε συνδυασμό με την κλασική αντιλεϊσμανιακή θεραπεία, με ενθαρ ρυντικά αποτελέσματα (Borja-Cabrera et al 2010). Πρόσφατα εγκρίθηκε και ένα άλλο αντιλεϊσμανιακό εμβόλιο (Canileish, Virbac) για ορισμένες χώρες της Ευρωπαϊκής Ένωσης, μεταξύ των οποίων και η Ελλά δα.…”

Section: πόσο χρήσιμος είναι ο εμβολιασμός για τη λεϊσμα-νίωση τον σκunclassified

New vaccination protocols for the dog and cat: the challenge of today for a better and safer prevention

Mylonakis

Koutinas

Saridomichelakis

et al. 2017

J Hellenic Vet Med Soc

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Vaccinations are an integral part of a comprehensive preventive health care program targeting to minimize the incidence of major canine and feline infectious diseases. Currently, vaccination practices are re-evaluated globally towards a twofold objective: to strengthen "herd immunity", which depends on the percentage of vaccinated animals in a population, and to reduce the "vaccine load" per animal in order to minimize the vaccine-associated adverse reactions. To this end, the updated canine and feline vaccination guidelines, encourage the vaccination of as many animals as possible, while at the same time classify the vaccines into core, non-core and not recommended. Core vaccines should be administered, if possible, to every dog and cat.Canine parvovirus-2, canine adenovirus-2, canine distemper virus, feline parvovirus, feline calicivirus/herpesvirus-1 and rabies vaccines fall into this category. Non-core vaccines are selectively given to dogs and cats after assessing the risk/benefit ratio. There are also vaccines for which there is currently no sufficient scientific evidence to justify their use. Importantly, after the one-year booster inoculation that follows the completion of the initial puppy/kitten vaccination series, core vaccines should be given no more frequently than every three years, as the duration of the protective immunity far exceeds this time interval. This review focuses on the updated canine and feline vaccination guidelines pertaining to the individual animal as well as to those living in groups. Important questions related to vaccination programs and to relevant adverse reactions are also answered. An effort has been made to align these guidelines according to what is considered a "norm" among the small amimal practitioners in Greece.

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Immunotherapy with the saponin enriched-Leishmune® vaccine versus immunochemotherapy in dogs with natural canine visceral leishmaniasis

Cited by 56 publications

References 50 publications

Antigenic extracts of Leishmania braziliensis and Leishmania amazonensis associated with saponin partially protects BALB/c mice against Leishmania chagasi infection by suppressing IL-10 and IL-4 production

Antigenic extracts of Leishmania braziliensis and Leishmania amazonensis associated with saponin partially protects BALB/c mice against Leishmania chagasi infection by suppressing IL-10 and IL-4 production

Examining the reservoir potential of animal species for $$\varvec{\textit{Leishmania infantum}}$$ Leishmania infantum infection

New vaccination protocols for the dog and cat: the challenge of today for a better and safer prevention

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