Abstract:Introduction
Recently Walter et al. (Nature med 2012) demonstrated that induction of T cell responses to tumor-associated antigens (TAA) after peptide vaccination (IMA901) is associated with significantly prolonged overall survival in patients with advanced renal cell carcinoma (RCC). Between August 2003 and November 2005 we performed a phase I/II non-randomized study to analyze the feasibility and safety of an mRNA-based vaccination as well as immunological and clinical responses in patients… Show more
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