Immunotherapy with cat- and dog-dander extracts IV. Effects of 2 years of treatment

Lilja, G.; Sundin, Bo; Graff‐Lonnevig, V.; Hedlin, Gunilla; Heilborn, H.; Norrlind, K.; Pegelow, Kjell-Orvar; Løwenstein, Henning

doi:10.1016/0091-6749(89)90475-2

Cited by 92 publications

(23 citation statements)

References 26 publications

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“…The results of rush immunotherapy studies using non-modified or formaldehyde-modified allergen vaccines without premedication suggest that this schedule carries a great risk of systemic reactions, ranging from 27 [34] to 100% [35] of the patients treated. In 2 studies, premedicating the patients reduced the incidence of systemic reactions from 36 to 16% [28] and from 73 to 27% [36], which is similar to the incidence of systemic reactions that occur using conventional build-up schedules (0.05–3.2% per injection or 0.84–46.7% of the patients) as shown by Stewart and Lockey [37].…”

Section: Discussionmentioning

confidence: 99%

Safety of an Ultra-Rush Immunotherapy Build-Up Schedule with Therapeutic Vaccines Containing Depigmented and Polymerized Allergen Extracts

Casanovas¹,

Martin²,

Jiménez³

et al. 2006

Int Arch Allergy Immunol

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Background: Four administration schedules of immunotherapy have been reported: conventional, cluster, rush and ultra-rush. Objectives: To evaluate the safety and the clinical advantage of using standardized modified allergen extracts in an ultra-rush protocol without premedication and/or hospitalization. Material and Methods: One thousand and sixty-eight patients with rhinoconjunctivitis and/or asthma sensitized to mites and/or pollen were included in a prospective observational study. Patients received a therapeutic vaccine containing depigmented and glutaraldehyde-modified extracts (mites and/or pollens) adsorbed onto alum prescribed by a specialist. The schedule of administration consisted of injecting 0.2 and 0.3 ml of the vial of maximum concentration during the first day of immunotherapy, separated by a time interval of 30 min. All patients reached the maximum dose (0.5 ml) after 2 injections. Tolerance was assessed by recording all side reactions related to immunotherapy, classified according to the criteria of the EAACI. Results: The total number of injections was 2,136. All patients reached the maximum established dose on the 1st day. No premedication was used. Seven clinically relevant local reactions were recorded. The systemic reactions were 5 grade-1 (2 immediate and 3 delayed) and 3 delayed grade-2 reactions. Conclusions: The therapeutic vaccines containing chemically modified extracts can be administered using an alternative ultra-rush schedule in an immunotherapy unit, reaching the maximum dose on the 1st day with 2 injections, without the need of premedication and/or hospitalization.

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Section: Discussionmentioning

confidence: 99%

Safety of an Ultra-Rush Immunotherapy Build-Up Schedule with Therapeutic Vaccines Containing Depigmented and Polymerized Allergen Extracts

Casanovas¹,

Martin²,

Jiménez³

et al. 2006

Int Arch Allergy Immunol

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show abstract

“…Treatment of cat allergy by allergen injections is often employed, but clinical results are, in part, controversial. Because only crude dander extract is available for the treatment of cat allergy (4,5), alternative formulations have been proposed (6,7).…”

mentioning

confidence: 99%

Formation of Disulfide Bonds and Homodimers of the Major Cat Allergen Fel d 1 Equivalent to the Natural Allergen by Expression in Escherichia coli

Grönlund

Bergman

Sandström

et al. 2003

Journal of Biological Chemistry

102

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“…However, specific immunotherapy did not protect against allergen-induced increases in non-specific bronchial hyperresponsiveness. Other studies have reported reductions in both specific bronchial reactivity (to cat dander) and non-specific reactivity (to histamine) after specific immunotherapy for cat allergy [54].…”

Section: Effects On Natural History Of Allergic Diseasementioning

confidence: 98%

C5 Perspectives of immunotherapy in the management of asthma and other allergic conditions

Frew

2011

Principles of Immunopharmacology

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Immunotherapy with cat- and dog-dander extracts IV. Effects of 2 years of treatment

Cited by 92 publications

References 26 publications

Safety of an Ultra-Rush Immunotherapy Build-Up Schedule with Therapeutic Vaccines Containing Depigmented and Polymerized Allergen Extracts

Safety of an Ultra-Rush Immunotherapy Build-Up Schedule with Therapeutic Vaccines Containing Depigmented and Polymerized Allergen Extracts

Formation of Disulfide Bonds and Homodimers of the Major Cat Allergen Fel d 1 Equivalent to the Natural Allergen by Expression in Escherichia coli

C5 Perspectives of immunotherapy in the management of asthma and other allergic conditions

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