Immunotherapy using purified protein derivative in the treatment of warts: An open uncontrolled trial

Saoji, Vikrant; Lade, Nitin; Gadegone, Rutuja W; Bhat, Arun

doi:10.4103/0378-6323.171650

Cited by 56 publications

(95 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…24 Follow up for a period of six months after release from treatment showed no recurrences in both the groups, however a similar study showed recurrence in 1.8% of the cases treated with PPD immunotherapy at 6 months after treatment. 12 Despite a small sample size in the present study both intralesional PPD and BCG groups showed good response in the treatment of multiple warts, however PPD was marginally better.…”

Section: Discussioncontrasting

confidence: 59%

“…A similar study showed 80%complete clearance in multiple verrucae vulgaris (> 10 warts) and 67% complete resolution in multiple verrucae plana (> 10 warts). 12 The difference of higher resolution in their study can be attributed due to higher quantity of PPD being used as well antigen being injected in each wart. Another study on intralesional tuberculin in 17 patients with warts showed complete clearance in 5 (29%) patients, partial response in 10 (59%) patients, and no response in 2 (12%) patients, similar to our study.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Role of physiotherapy in palliative care

Rajashekar¹,

Amulya²,

Sathish³

et al. 2020

IJN

View full text Add to dashboard Cite

Introduction: Multiple cutaneous warts are often asymptomatic, cosmetically disfiguring and difficult to treat with conventional modalities, hence immunotherapeutic modalities can be used in such cases. There are no comparitive studies with immunotherapeutic modalities for the treatment of multiple and extensive warts. This study aims to compare the efficacy and safety of intralesional BCG and PPD in the treatment of multiple cutaneous warts. Materials and Methods: It is a double blinded randomized clinical trial involving thirty patients having more than ten cutaneous warts with a positive mantoux reaction. The patients were randomly allocated into two treatment groups, group A -PPD and group B -BCG. Intralesional injections were given at two weekly intervals till complete clearance of all the warts or for a maximum of four sessions in both the groups. Response in injected warts and distant warts was assessed at each visit and sequential clinical photographic records were maintained. Results: Thirty patients with positive mantoux reaction were enrolled for the trial, 17 patients in group A (PPD) and 13 patients in group B (BCG). Complete resolution of lesions was noted in 35.3% in PPD group and 30.8% in BCG group and partial resolution was noted in 47.0% and 38.4 % in PPD and BCG group respectively. Conclusion: Intralesional PPD showed marginally better results than intralesional BCG in the treatment of multiple cutaneous warts. Majority of the patients treated with BCG had tender nodule at injection site.

show abstract

Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 98%

Role of physiotherapy in palliative care

Rajashekar¹,

Amulya²,

Sathish³

et al. 2020

IJN

View full text Add to dashboard Cite

show abstract

“…Immunotherapy is efficacious in pediatric and adult patients, particularly in cases of multiple or recalcitrant warts. Studies of Candida antigen, MMR, and PPD provided comparable complete response rates of injected warts, from 39% to 88% for candida, 26.5% to 92% for MMR, and 23.3% to 94.4% for PPD . However, BCG appears to be an inferior treatment choice, with clearance rates limited at 33.3%‐39.7%,…”

Section: Discussionmentioning

confidence: 94%

“…Saoji et al injected 2.5 tuberculin units (TU) of PPD into a maximum of 10 lesions (max 25 TU per session) at 2‐week intervals for 4 sessions. 76% showed complete clearance and side effects included mild pain and redness at the injection site . Kerure et al instead used a dosage of 10 IU (0.1 mL) injected into the largest wart every 2 weeks, until wart resolution or a maximum of six treatments.…”

Section: Resultsmentioning

confidence: 99%

Intralesional immunotherapy for pediatric warts: A review

Fields

Saikaly

Schoch

2020

Pediatric Dermatology

View full text Add to dashboard Cite

Cutaneous warts are a common pediatric complaint with modest response to first‐line treatments. Warts are a manifestation of human papillomavirus (HPV) infection and are cleared by cell‐mediated immunity (CMI). Intralesional immunotherapy treatments have been studied as alternative therapies, particularly for recalcitrant or multiple warts, including Candida antigen, mumps antigen, the combined measles, mumps, and rubella (MMR) vaccine, tuberculin purified protein derivative (PPD), and bacille Calmette‐Guerin (BCG) vaccine. These treatments are thought to increase HPV recognition by stimulating CMI. In this review, we evaluate and compare the efficacy and adverse effects of intralesional immunotherapy in the treatment of pediatric warts. Articles met inclusion criteria if they specifically evaluated the effects of intralesional immunotherapy (candida, MMR, tuberculin PPD, or BCG) as treatment for cutaneous warts in a pediatric population, and if they quantified treatment effect in a reproducible manner. Twenty‐one studies met criteria. Many studies demonstrated complete clearance of injected common warts in pediatric patients with clearance rates ranging from 23.3% to 95.2%. Distant wart resolution was common. Intralesional immunotherapy is a promising treatment option for cutaneous warts in children.

show abstract

“…Both studies showed low recurrence among patients, but some patients (<30%) experienced flu-like symptoms during treatment [21 -29]. In a study performed by Saoji et al, tuberculin PPD showed a complete response rate of 76% in four treatments with very minimal adverse reactions to the antigen [22]. Myobacterium w vaccine showed complete response rates as high as 89% in a study performed by Gupta et al and 93% in a study performed by Garg and Baveja [23,30].…”

Section: Efficacy Of Intralesional Immunotherapies and Intralesional mentioning

confidence: 97%

Wart Immunotherapies: A Short Review

Sefcik¹,

Burkhart²

2017

TODJ

View full text Add to dashboard Cite

Objective:To review the efficacy and costs of various contact immunotherapies, contact allergens, intralesional immunotherapies, and intralesional cytotoxic agents for the treatment of recalcitrant warts. Background:Cutaneous warts are common viral skin lesions caused by human papillomavirus that can be challenging to treat and frustrating for physicians and patients. Although several treatment options exist, there is no single treatment that can ensure a complete response with lack of lesion recurrence. Immunotherapies for recalcitrant warts present as a cost-effective, efficient therapy option for patients. Intralesional approaches have the added benefit of affecting warts at locations distant to the target location by inducing a systemic Tcell mediated response in the body. Results:Various contact immunotherapies, contact allergens, intralesional immunotherapies, and intralesional cytotoxic agents have shown to be effective in treating warts. The costs of each treatment varies drastically from around $10 US to over $1000 US to achieve a complete response. Several antigens were found to be both efficacious and cost effective. Conclusion:Although efficacy of several antigens has been confirmed by randomized studies, more randomized comparative studies will need to be performed in order to determine the best antigen and correct standardized doses for the treatment of warts in individual patients. It is important to note that individual response to antigen type and dose may vary among patients. Therefore, further studies may play an important role in the use of immunotherapies in a clinical setting.

show abstract

Immunotherapy using purified protein derivative in the treatment of warts: An open uncontrolled trial

Abstract: Immunotherapy with PPD is helpful in the treatment of cutaneous warts.

Cited by 56 publications

References 0 publications

Role of physiotherapy in palliative care

Role of physiotherapy in palliative care

Intralesional immunotherapy for pediatric warts: A review

Wart Immunotherapies: A Short Review

Contact Info

Product

Resources

About