Immunotherapy targeting the obese white adipose tissue microenvironment: Focus on non-communicable diseases

Priscilla, Lia; Yoo, Chaerim; Jang, Seonmi; Park, Sewon; Lim, Gayoung; Kim, Taekyun; Lee, Dong Yun

doi:10.1016/j.bioactmat.2024.01.027

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Treatment Of Inflammation In Obese Adipose Tissue1

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2024

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“…Additionally, the pro-inflammatory cytokines secreted by obese WATME are closely linked to the development of atherosclerosis. Therefore, employing WATME-specific immunotherapy to inhibit the secretion of pro-inflammatory cytokines can effectively treat diseases induced by obesity, such as type 2 diabetes and coronary heart disease ( 119 ).…”

Section: Treatment Of Inflammation In Obese Adipose Tissuementioning

confidence: 99%

Endoplasmic reticulum stress: bridging inflammation and obesity-associated adipose tissue

Ma,

Zhang,

Zhao

et al. 2024

Front. Immunol.

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Obesity presents a significant global health challenge, increasing the susceptibility to chronic conditions such as diabetes, cardiovascular disease, and hypertension. Within the context of obesity, lipid metabolism, adipose tissue formation, and inflammation are intricately linked to endoplasmic reticulum stress (ERS). ERS modulates metabolism, insulin signaling, inflammation, as well as cell proliferation and death through the unfolded protein response (UPR) pathway. Serving as a crucial nexus, ERS bridges the functionality of adipose tissue and the inflammatory response. In this review, we comprehensively elucidate the mechanisms by which ERS impacts adipose tissue function and inflammation in obesity, aiming to offer insights into targeting ERS for ameliorating metabolic dysregulation in obesity-associated chronic diseases such as hyperlipidemia, hypertension, fatty liver, and type 2 diabetes.

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Section: Treatment Of Inflammation In Obese Adipose Tissuementioning

confidence: 99%