Immunotherapy‐responsive brainstem lesion accompanied with anti‐galactocerebroside antibody

Abstract

Background: Brainstem lesions are a diagnostic challenge and clinicians have to differentiate between many diseases including acute disseminated encephalomyelitis, multiple sclerosis (MS), Bickerstaff brainstem encephalitis (BBE) and brain tumors.The anti-galactocerebroside (Gal-C) antibody is an anti-glycolipid antibody that is often detected in autoimmune peripheral neuropathy. However, anti-Gal-C antibody is rarely detected in autoimmune central nervous system diseases. Here, we report the case of an anti-Gal-C antibody-positive patient who had a brainstem lesion that mimicked MS and responded to immunotherapy. Case presentation:We report a 32-year-old woman who presented with subacute numbness of the right lower extremities and hemiataxia. Her cerebrospinal fluid examination showed an elevated myelin basic protein level and an oligoclonal band.How to cite this article: Shiraishi W. Immunotherapyresponsive brainstem lesion accompanied with antigalactocerebroside antibody.