Immunotherapy: responsive autoimmune encephalopathy associated with bullous pemphigoid

Soni, A; Irani, Sarosh R.; Lang, Bethan; Taghipour, Kathy; Mann, R. J.; Vincent, A; Collins, Damian

doi:10.1136/jnnp.2008.165894

Cited by 3 publications

(2 citation statements)

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“…Also, in a study of collagen XVII and BPAG1 autoantibodies in the serum of 337 individuals with no signs of BP [63], of the 25 found to be positive, 5 had neurologic diseases listed in their medical records; in all but one case the amount of collagen XVII antibodies was greater than the amount for BPAG1 (correspondence [64]). On the other hand, Soni et al [65] found evidence of neither collagen XVII nor BPAG1 antibodies in a case of autoimmune encephalopathy with BP.…”

Section: The Possible Role Of Collagen XVII As a Common Antigen Inmentioning

confidence: 99%

Collagen XVII: A Shared Antigen in Neurodermatological Interactions?

Seppänen

2013

Clinical and Developmental Immunology

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Collagen XVII is a nonfibril-forming transmembrane collagen, which functions as both a matrix protein and a cell-surface receptor. It is particularly copious in the skin, where it is known to be a structural component of hemidesmosomes. In addition, collagen XVII has been found to be present in the central nervous system, thus offering an explanation for the statistical association between bullous pemphigoid, in which autoimmunity is directed against dermal collagen XVII, and neurological diseases. In support of the hypothesis that collagen XVII serves as a shared antigen mediating an immune response between skin and brain, research on animal and human tissue, as well as numerous epidemiological and case studies, is presented.

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Section: The Possible Role Of Collagen XVII As a Common Antigen Inmentioning

confidence: 99%

Collagen XVII: A Shared Antigen in Neurodermatological Interactions?

Seppänen

2013

Clinical and Developmental Immunology

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“…[ 1 ] BP antigens exist also in their neurological isoforms located in the central nervous system. Certain studies[ 2 ] directly linked ND and BP through an antibody-based mechanism.…”

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confidence: 99%