Immunotherapy of Human Cancer

Hersh, Evan M.; Mavligit, Giora M.; Gutterman, Jordan U.; Richman, Stephen P.

doi:10.1007/978-1-4684-2739-4_11

Cited by 12 publications

(7 citation statements)

References 319 publications

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“…In order to increase the immunogenicity of tumor cells and avoid growth of tumor at the site of injection, various physical, chemical and biological means have been used by other investigators to modify tumor cells. The physical methods for example, include simple mechanical disruption, disruption by freezing and thawing, heat treatment, and irradiation by X rays or ultraviolet light [7]. Revez found that antigens different from those present in primary tumor were present in tumor cells pretreated with irradiation [13].…”

Section: Discussionmentioning

confidence: 99%

Increased efficiency of immunotherapy using irradiated tumor cells

Fitzgerald

Sonis

et al. 1987

Cancer Immunol Immunother

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The efficacy of irradiated tumor cells combined with chemotherapy or non-specific immunostimulation with complete Freund's adjuvant was tested in a model of minimal residual tumor-bearing syngeneic mice. Male C57BL/6J mice were innoculated in the right rear leg with live tumor cells from a methylcholanthrene induced fibrosarcoma. The tumor was resected when it reached 0.7 cm in diameter and animals were treated with doses of irradiated tumor cells (XTC) from the primary tumor ranging in number from 1 X 10(3) to 9 X 10(3). Best survival was noted using 5 X 10(3) XTC combined with irradiated tumor cells of liver or pulmonary metastases origin, complete Freund's adjuvant or cytoxan. The combination of irradiated tumor cells of metastatic origin did not enhance the therapeutic effect of XTC alone. Freund's adjuvant was not of benefit in enhancing the efficacy of XTC. However, improved survival was noted when chemotherapy in the form of cytoxan was used to supplement XTC. Our data suggests that XTC is more efficacious as a mode of immunotherapy than are live tumor cells. The dose of XTC used is critical in determining its effect. Chemotherapy appears to enhance the benefit of XTC.

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Section: Discussionmentioning

confidence: 99%

Increased efficiency of immunotherapy using irradiated tumor cells

Fitzgerald

Sonis

et al. 1987

Cancer Immunol Immunother

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“…A number of observations indicate that tumors elicit an immune response from the tumor-bearing host (Old and Boyse, 1964;Klein, 1966;Hersh et al, 1973). However, in spite of a tumor-specific response, progressive tumor growth may continue.…”

Section: Introductionmentioning

confidence: 97%

Active immunotherapy of L1210 leukemia with neuraminidase-treated, drug-resistant L1210 sublines

LeFever

Killion

Kollmorgen

1976

Cancer Immunol Immunother

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“…The immunogenicity of such tumors is recognized by their ability to elicit a protective immune response in the tumor-bearing Reprint requests should be addressed to: S. D. Deodhar host (Old and Boyse, 1964;Klein, 1966;Hersh et al, 1973). Tumor-associated cell-surface antigens have also been shown on a variety of human tumors, and the subject of human tumor immunology has been reviewed by Oettgen and Boyse (1971) and Reed (1974).…”

Section: Introductionmentioning

confidence: 98%