Immunotherapy in hepatocellular cancer

Fountzilas, Christos; Evans, Rachel; Alaklabi, Sabah; Iyer, Renuka

doi:10.1016/bs.acr.2020.12.002

Cited by 2 publications

(1 citation statement)

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“…In the past decade, there has been significant progress in the development and widespread use of anti-VEGF-VEGFR medicines, including an anti-VEGF-A neutralizing antibody and multi-kinase inhibitors. These drugs have been mostly employed in managing prominent solid tumors [110]. The therapeutic effectiveness of these medications has been thoroughly assessed, yet none provide full treatment for individuals with cancer.…”

Section: Overview Of Vegfrmentioning

confidence: 99%

The significance of quinazoline derivatives as potential multi-target anti-cancer agents: review article

Mansour,

Abbas,

AboulMagd

et al. 2023

Journal of advanced Biomedical and Pharmaceutical Sciences

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In recent years, the use of quinazoline and its derivatives as structural scaffolds has shown significant promise in drug design. These compounds have shown significant biological efficacy in the treatment of a variety of diseases, including cancer. Quinazoline has shown a significant reduction in adverse effects and improved treatment effectiveness, making it a very attractive candidate for further investigation and advancement in therapeutic interventions. This review provides a focus on the use of small-molecule targeted therapy. The discussion briefly introduces the epidermal growth factor receptor tyrosine kinase (EGFR TK), its mutations, and the development of innovative molecules in this domain. Furthermore, the current review digs into the concept of multi-targeted anticancer agents, particularly on quinazoline-based compounds that can obstruct several targets. Notably, these targets include EGFR/VEGFR dual inhibitors, EGFR/HDAC dual inhibitors, and a variety of other EGFR-related targets.

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Section: Overview Of Vegfrmentioning

confidence: 99%