Immunotherapy in Eosinophilic Granulomatosis with Polyangiitis: A New Step Forward?

Puéchal, Xavier

doi:10.4172/2471-9544.1000e106

Cited by 2 publications

(2 citation statements)

References 39 publications

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“…EGPA is the less frequent of AAV, a group of chronic inflammatory pauci-imunne disorders that involve small vessels [6][7][8]. The 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides defines it as an eosinophil-rich and necrotizing granulomatous inflammation, often involving the respiratory tract, and necrotizing vasculitis predominantly affecting small to medium vessels, associated with asthma and eosinophilia [9].…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic Granulomatosis with Polyangiitis Associated to Chromophobe Renal Cell Carcinoma: A Case Report

Oliveira¹,

Simaan²,

Neto³

et al. 2017

J Vasc

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Paraneoplastic syndromes are characterized by the set of signs and symptoms of an underlying cancer, frequently occult, due to a variety of remote tumor effects unrelated to the mechanical impact of the tumor mass or distant metastasis [1,2]. Among these syndromes, paraneoplastic vasculitis are very rare, especially necrotizing systemic vasculitis. It is estimated that 2-5% of all causes of vasculitis are paraneoplastic, with the most common presentation being leukocitoclastic cutaneous vasculitis related to hematological malignancies [1,3,4], and fewer cases related to solid organ tumors as an underlying cause.There are some reports of paraneoplastic ANCA-associated vasculitis (AAV), especially granulomatosis with polyangiitis associated with hematological malignancies and with solid organ tumors such as lung and renal carcinomas [5]. We report a case of eosinophilic granulomatosis with polyangiitis (EGPA) associated to chromophobe renal cell carcinoma (chCRR), an unusual form of malignant renal neoplasm, with complete remission of vasculitis after tumor resection.It is important to be aware of the rare association between vasculitis and cancer, since early recognition could provide proper treatment and better prognosis. A 62 year-old man presented with painful palpable purpura on lower limbs and palms, dry cough, dyspnea and fever four weeks prior to admission. He had a long medical history of hypertension and diabetes, and lifetime tobacco exposure of 35 packyears.There was also a severe persistent asthma starting three years before. Weight loss, abdominal pain and urinary symptoms were absent. On physical examination, there were skin lesions (Figure 1), wheezing on chest auscultation and a body mass index of 27.2 kg/m 2 . Laboratory tests showed marked eosinophilia (5,700 cells/mm 3 at admission, peaking 15,520 cells/mm 3 during hospital stay), elevated erythrocyte sedimentation rate (80 mm/h) and C-reactive protein (2,6 mg/dL, NR <0,5 mg/dL). Renal function and urine analysis were normal. Skin biopsy demonstrated eosinophilic leukocitoclastic vasculitis of small vessels with fibrinoid necrosis and eosinophilic perivascular infiltrates (Figure 2). Antinuclear antibody and antineutrophil cytoplasmic antibodies (ANCA) tested negative. Serological tests for hepatitis B and C viruses and acquired human immunodeficiency virus were negative. At admission, chest radiography revealed pulmonary infiltrates.A computerized tomography (CT) scan was performed, showing bilateral alveolar infiltrates and a small indeterminate solid nodule on left lower lobe. Daily oral prednisone was started (up to 1 mg/kg) with no improvement. The patient evolved with respiratory insufficiency, with severe hypoxemia, and then intravenous (IV) methylprednisolone 1 g/day was prescribed for three days. There was a striking improvement, with normalization of eosinophil count and complete resolution of respiratory symptoms. However, the cutaneous vasculitis not only persisted, but also progressed some days after the IV glucocorticoid therapy, ...

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Section: Discussionmentioning

confidence: 99%

Eosinophilic Granulomatosis with Polyangiitis Associated to Chromophobe Renal Cell Carcinoma: A Case Report

Oliveira¹,

Simaan²,

Neto³

et al. 2017

J Vasc

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“…Nanotechnology, gives outstanding potential in revolutionizing the control of melanoma. The scope of such molecules extends to therapeutic packages consisting of photodynamic and photograph thermic remedy in which moderate is transformed to warmth to combat neoplastic lesions [60][61][62][63][64] ; immunotherapy [65][66][67][68] wherein nanoparticles are used as immunomodulators [69][70][71][72] or vaccines against cancer cells; and gene therapy which targets pro-oncogenes on sign transduction pathways.…”

Section: Nano Pumpsmentioning

confidence: 99%

Nanotechnology - A Path to a Sustainable Future

Goyal¹,

Ghildiyal²

2016

Res. Rev. J Mat. Sci

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Nanotechnology is a varied area of technology which offers with floor technology, organic chemistry, molecular biology, semiconductor physics and micro-fabrication and so on. It's far the usage of era on the nano (10-9) degree. A fundamental definition of nanotechnology is the examine manipulation and manufacture of highly minute machines or devices. The related studies and applications are similarly diverse, ranging from extension of conventional physics to completely new techniques primarily based upon developing new substances with new dimensions on nanoscale. Scientists presently debate the destiny implications of nanotechnology. Nanotechnology can be capable of create many new substances and gadgets with a great variety of applications, which embody medication, electronics, biomaterials and so on. From the contemporary overview paper we are able to finish that nanomaterial's is located to have massive applications in diverse fields which have been described inside the paper. So, we can finish that Nanotechnology performs a prime position in nowadays studies paintings.

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Immunotherapy in Eosinophilic Granulomatosis with Polyangiitis: A New Step Forward?

Cited by 2 publications

References 39 publications

Eosinophilic Granulomatosis with Polyangiitis Associated to Chromophobe Renal Cell Carcinoma: A Case Report

Eosinophilic Granulomatosis with Polyangiitis Associated to Chromophobe Renal Cell Carcinoma: A Case Report

Nanotechnology - A Path to a Sustainable Future

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