Immunotherapy in Allergic Rhinitis: It’s Effect on the Immune System and Clinical Symptoms

Kouzegaran, Samaneh; Zamani, Mohsen; Faridhosseini, Reza; Rafatpanah, Houshang; Rezaee, Abdolrahim; Yousefzadeh, Hadis; Movahed, Rahman; Azad, Farahzad Jabbari; Tehrani, H.

doi:10.3889/oamjms.2018.264

Cited by 10 publications

(6 citation statements)

References 18 publications

(38 reference statements)

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“…Various immune-related factors are involved in its development and progression, including chemokines and their receptors, EPO, interleukin and its receptors, and leukotrienes. 3 The vitamin D receptor (VDR) gene can regulate immune responses in the body, inhibit abnormal cell activation, and maintain the stability of cell function. 4 A number of clinical studies have confirmed that vitamin D can effectively prevent and treat bronchial asthma by regulating the immune system, and both AR and bronchial asthma have similar etiology and pathogenesis and belong to the same category of diseases.…”

Section: Introductionmentioning

confidence: 99%

<p>Association Between Vitamin D Receptor Gene Polymorphism rs2228570 and Allergic Rhinitis</p>

Zhang¹,

Xu²

2020

PGPM

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Background: Vitamin D receptor (VDR) gene polymorphisms are involved in a variety of immune-related diseases, and VDR is associated with allergic rhinitis. The present study explored the associations between VDR gene polymorphisms and allergic rhinitis in the Chinese population. Methods: The study population consisted of 400 patients with allergic rhinitis and 400 healthy controls. General characteristics were determined by interview. Blood DNA was extracted and genotyping was performed via matrix-assisted laser desorption/ionization timeof-flight mass spectrometry. The associations of each genetic variant with risk for AR were assessed by calculating the odds ratio (OR) with 95% confidence interval (95% CI). Results: No significant differences were observed in general characteristics between cases and controls. The distributions of genotypes at the rs2228570 locus of the VDR gene conformed to Hardy-Weinberg equilibrium. There was a significant difference in the distribution of rs2228570 genotype (P<0.001) between cases and controls. Compared to GG and GA genotypes, the AA genotype increased the risk of AR (OR=3.27, 95% CI: 2.10-5.11, P=0.000; OR=2.58, 95% CI:1.63-4.08, P<0.001). Similar results were also observed in the dominant model (OR=1.64, 95% CI:1.24-2.17, P<0.001) and codominant model (OR=2.95, 95% CI:1.93-4.51, P<0.001). The A allele was still associated with elevated risk gene for AR after adjusting for potential confounding factors. Subgroup analyses indicated an interaction between alcohol and rs2228570 in the risk of allergic rhinitis. The A allele also increased the risk for AR in the population without asthma (OR=1.85, 95% CI:1.46-2.34, P<0.001). Conclusion: VDR gene polymorphism is associated with AR, and the AA genotype of rs2228570 is associated with the increased risk of AR in the Chinese population.

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Section: Introductionmentioning

confidence: 99%

<p>Association Between Vitamin D Receptor Gene Polymorphism rs2228570 and Allergic Rhinitis</p>

Zhang¹,

Xu²

2020

PGPM

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“…The clinical treatment of AR mainly includes avoiding contact with allergens, drug treatment, and immunotherapy. However, studies on effective drugs in prevention and treatment of AR progress slowly, and immunotherapy still remains the most effective treatment in clinical practice [5]. Thus, it is urgent to develop novel approaches to the treatment of AR.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Circular RNA (CircRNA) Ddx17 in Ovalbumin (OVA)-Induced Allergic Rhinitis (AR) Mice

Liu

Cao

2020

Med Sci Monit

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Background:CircRNAs are involved in multiple biological processes, especially when they act as sponges of miRNA. Thus, the present study investigated the effect of circDdx17 on allergic rhinitis (AR) in an animal model, and determined the miRNA that was involved in this effect. Material/Methods:The AR model was created by repetitive stimulation of ovalbumin (OVA). The levels of mRNAs in plasma were determined by qPCR. CircDdx17 stability was assessed using RNase R. The interaction between circDdx17 and miR-17-5p was predicted by bioinformatics and confirmed by dual luciferase assay. Moreover, the frequencies of rubbing and sneezing and pathological changes were recorded, and OVA-specific IgE, tumor necrosis factor (TNF)-a, interleukin (IL)-4, and IL-5 levels were detected by ELISA. Results:Levels of circDdx17 were decreased in OVA-induced AR mice, and miR-17-5p interacted with circDdx17 in spleen cells derived from mice. Moreover, circDdx17 overexpression reduced the expression of miR-17-5p, OVA-specific IgE, TNF-a, IL-4, and IL-5, as well as the frequencies of rubbing and sneezing, and alleviated pathological changes in OVA-induced AR mice. Conclusions:CircDdx17 appears to have a protective effect on mice in the progression of AR. Specifically, overexpression of circDdx17 inhibited the expression of miR-17-5p and alleviated the condition of AR. Therefore, circDdx17 appears to be a good candidate for use in prevention of AR. However, the detailed mechanism underlying the circDdx17/miR-17-5p regulatory pathway requires further study.

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“…For example, in further studies, it might be possible to show that Th polarization modulation can be exploited to treat DM and AR. In fact, immunotherapy based on Th polarization is already being executed for AR treatment 19 . In the same manner, application of Th polarization in DM treatment could also be possible.…”

Section: Discussionmentioning

confidence: 99%

Bi-directional association between allergic rhinitis and diabetes mellitus from the national representative data of South Korea

Lee

Jeon

Jung

2021

Sci Rep

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Allergic rhinitis (AR) and diabetes mellitus (DM) share a common cause in inflammation; however, potential relationships between them are not clear. Therefore, we aimed to explore the associations between AR and DM. In this cross-sectional study, data were extracted from the Korean National Health and Nutrition Examination Survey 2007–2018 and weighted based on sociodemographic characters. AR and DM were defined by diagnoses thereof. Since self-reporting was not perfect, in order to complement the validity, we additionally performed sensitivity analysis by defining DM according to HbA1c and medication history. After excluding invalid data, the number of final participants was 29,246 (mean age, 54.95 ± 14.27 years). We calculated the odds ratio (OR) of newly self-reported DM among AR patients without DM history by multivariable logistic regression adjusted for potential confounders. A reverse association was also assessed. Patients with AR showed lower ORs for DM than those without AR (OR, 95% CI: men, 0.28, 0.19–0.42; women, 0.33, 0.24–0.46). Similarly, DM patients showed lower ORs for AR than patients without DM (men, 0.41, 0.31–0.56; women, 0.34, 0.25–0.46). The same results were obtained in sensitivity analysis defining DM according to HbA1c levels or DM treatment and in stratification analysis for age, residency, comorbidity, BMI, and menopause. In conclusion, we discovered that AR and DM show mutual inverse associations, regardless of sex, in individuals aged 30 years and older.

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Immunotherapy in Allergic Rhinitis: It’s Effect on the Immune System and Clinical Symptoms

Cited by 10 publications

References 18 publications

<p>Association Between Vitamin D Receptor Gene Polymorphism rs2228570 and Allergic Rhinitis</p>

<p>Association Between Vitamin D Receptor Gene Polymorphism rs2228570 and Allergic Rhinitis</p>

Protective Effect of Circular RNA (CircRNA) Ddx17 in Ovalbumin (OVA)-Induced Allergic Rhinitis (AR) Mice

Bi-directional association between allergic rhinitis and diabetes mellitus from the national representative data of South Korea

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