Immunotherapy for peanut allergy

Lee, T H; Chan, June; Lau, Vivian W Y; Lee, W L; Lau, Pui-man; Lo, Mentzing

doi:10.12809/hkmj144243

Cited by 8 publications

(13 citation statements)

References 25 publications

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“…Table 1. [11][12][13][14] In contrast to other studies, a study conducted in Hong Kong by Lee et al 11 did not have a rush immunotherapy phase (when several doses of peanuts were administered on day 1); instead, peanut dose was increased more gradually at 2-week intervals. Despite differences in study design, the outcomes from all the studies were similar.…”

Section: Peanut Oral Immunotherapy With Anti-immunoglobulin Ementioning

confidence: 91%

Peanut allergy and oral immunotherapy

Lee

Jkc

et al. 2019

Hong Kong Med J

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Peanut allergy is the commonest cause of foodinduced anaphylaxis in the world, and it can be fatal. There have been many recent improvements to achieve safe methods of peanut desensitisation, one of which is to use a combination of antiimmunoglobulin E and oral immunotherapy. We have treated 27 patients with anti-immunoglobulin E and oral immunotherapy, and report on the outcomes and incidence of adverse reactions encountered during treatment. The dose of peanut protein tolerated increased from a median baseline of 5 to 2000 mg after desensitisation, which is substantially more than would be encountered through accidental ingestion. The incidence of adverse reactions during the escalation phase of oral immunotherapy was 1.8%, and that during the maintenance phase was 0.6%. Most adverse reactions were mild; three episodes were severe enough to warrant withdrawal

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Section: Peanut Oral Immunotherapy With Anti-immunoglobulin Ementioning

confidence: 91%

Peanut allergy and oral immunotherapy

Lee

Jkc

et al. 2019

Hong Kong Med J

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“…This strategy seems to have been at least partly successful. The profile of allergy in HK has risen markedly in the past 3 years as evidenced by the increased local media attention on allergy related news items, professional newsletters and the numbers of peer reviewed publications including management guidelines and commentaries [13,17,[27][28][29][30][31][32][33]. Several new allergy clinics have been created in the government hospitals.…”

Section: Professional and Public Engagementmentioning

confidence: 99%

“…The nurses and dietitian were understandably concerned about the safety of the procedure due to lack of experience and were reluctant to offer oral desensitization. It was only after much discussion and reassurance that it was eventually agreed to undertake a pilot study [33] to assess feasibility and safety after approval by the Ethics committee and Hospital Management; with patients' informed consent; and with establishment of an ethics and data monitoring committee. The study was successful and in 2014 the hospital was able to offer the first peanut oral desensitization programme in HK and mainland China.…”

Section: Challenges For the Nurses And Other Staffmentioning

confidence: 99%

The Journey to Create the New Allergy Centre in Hong Kong

Lee¹

2018

PPN

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Allergic diseases are prevalent worldwide and Hong Kong (HK) is no exception [1][2][3][4][5][6][7][8][9][10][11]. This includes allergic asthma, rhinitis, eczema, food allergies and anaphylaxis. The diseases can cause significant morbidity and are sometimes life-threatening. Allergy services can help these patients as reported in the two examples below.The first example is a 10 year old boy with se vere milk allergy who had experienced an anaphylactic reaction af ter ingesting a very small volume of milk which resulted in admission to pediatric intensive care. The milk allergy was confirmed by both positive skin prick AbstractThere is a severely unmet need for allergy clinical services in Hong Kong (HK) especially for the adult population. This review chronicles the steps taken and the challenges faced in establishing a new Allergy Centre in HK from scratch. While the experience described is for only one Centre in one country, the information provided may help others who are starting up a new allergy service as it seems likely that they could undergo a similar journey.

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“…They publish position papers and clinical allergy practice guidelines. 3,45,46 They have their own websites and some of them have social media platforms to engage the Dermatology and Otolaryngology, respectively, and a Centre of Excellence in allergy is not intended to compete with specialists in these and other disciplines. To the contrary, successful Centres are trans-disciplinary and should be collaborating with colleagues to provide integrated and holistic care for complex patients who are often characterised by multisystem involvement.…”

Section: Professional Societies and Patient Organisationsmentioning

confidence: 99%

The unmet provision of allergy services in Hong Kong impairs capability for allergy prevention – implications for the Asia Pacific region

Lee

Leung

Wong

et al. 2017

Asian Pac J Allergy Immunol

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There is a high and rising prevalence of many allergic diseases in the Asia Pacific, including Hong Kong, which is unmatched by a commensurate provision of clinical allergy services. In the last 3 years, the allergy profile in Hong Kong has increased due to greater public engagement and more frequent educational activities, scientific outputs and publication of local guidelines on allergy prevention, diagnosis and treatment. Two new drug allergy clinics have been established in public hospitals, and for the first time in 20 years, Hong Kong has its first trainee in adult allergy. The current ratio of allergists per head of population has improved slightly from 1:1.46 (in 2014) to 1:1.17 million, but it is still low compared to many countries. The Hong Kong community is well supported by allergy-related professional societies and patient organisations. While the recent developments indicated some progress, Hong Kong remains inadequately equipped to take advantage of the new discoveries that may prevent allergic diseases and improve public health. There are also 5-fold more paediatric allergists than adult allergists per head of population. If this unbalance remains uncorrected, continuing care for allergic children as they grow into adulthood will be an increasing problem. This review provides recommendations to improve allergy service provision and training, including the creation of Centres of Excellence in allergy to drive the growth of this specialty.

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Immunotherapy for peanut allergy

Cited by 8 publications

References 25 publications

Peanut allergy and oral immunotherapy

Peanut allergy and oral immunotherapy

The Journey to Create the New Allergy Centre in Hong Kong

The unmet provision of allergy services in Hong Kong impairs capability for allergy prevention – implications for the Asia Pacific region

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