Immunotherapy as a potential treatment approach for currently incurable bone metastasis

Yang, Yong; Ollodart, Jenna; Contino, Kelly F.; Shiozawa, Yusuke

doi:10.1007/s00774-023-01404-3

Cited by 2 publications

(2 citation statements)

References 55 publications

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“…Immunotherapy presents a promising yet challenging approach for treating bone metastases, hindered by the bone marrow’s immunosuppressive environment, which protects against autoimmune insults but also limits immunotherapy’s effectiveness [ 198 ]. Strategies to overcome these challenges include targeting the immunosuppressive mechanisms, such as the role of mesenchymal stem cells (MSCs) and the TGFβ pathway, which inhibit antitumor immune responses.…”

Section: Future Directions In Bone Metastasis Research and Treatmentmentioning

confidence: 99%

Bridging the Gap in Understanding Bone Metastasis: A Multifaceted Perspective

Elaasser,

Arakil,

Mohammad

2024

IJMS

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The treatment of patients with advanced cancer poses clinical problems due to the complications that arise as the disease progresses. Bone metastases are a common problem that cancer patients may face, and currently, there are no effective drugs to treat these individuals. Prostate, breast, and lung cancers often spread to the bone, causing significant and disabling health conditions. The bone is a highly active and dynamic tissue and is considered a favorable environment for the growth of cancer. The role of osteoblasts and osteoclasts in the process of bone remodeling and the way in which their interactions change during the progression of metastasis is critical to understanding the pathophysiology of this disease. These interactions create a self-perpetuating loop that stimulates the growth of metastatic cells in the bone. The metabolic reprogramming of both cancer cells and cells in the bone microenvironment has serious implications for the development and progression of metastasis. Insight into the process of bone remodeling and the systemic elements that regulate this process, as well as the cellular changes that occur during the progression of bone metastases, is critical to the discovery of a cure for this disease. It is crucial to explore different therapeutic options that focus specifically on malignancy in the bone microenvironment in order to effectively treat this disease. This review will focus on the bone remodeling process and the effects of metabolic disorders as well as systemic factors like hormones and cytokines on the development of bone metastases. We will also examine the various therapeutic alternatives available today and the upcoming advances in novel treatments.

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Section: Future Directions In Bone Metastasis Research and Treatmentmentioning

confidence: 99%

Bridging the Gap in Understanding Bone Metastasis: A Multifaceted Perspective

Elaasser,

Arakil,

Mohammad

2024

IJMS

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“…It is noted that immunotherapy has achieved breakthrough in tumor treatment, which indicates great potential of immune system in bone tumor elimination. [ 5 ] However, few studies explored implants with immune‐activated characteristics to attack bone tumors. Given low infiltration of immune cells and reduction of pro‐inflammatory cytokines in microenvironment of bone tumors, [ 6 ] the activation of pro‐inflammatory immune cells is prerequisite for the immune system to fight with tumor cells, which presents challenges to develop implants with immune‐activated characteristics.…”

Section: Introductionmentioning

confidence: 99%

Probiotic Biofilm Modified 3D‐Printing Scaffolds for Improving Chemo‐Immunotherapy of Bone Tumor and Promoting Osteogenesis

Gu,

Fan,

Bao

et al. 2023

Adv Funct Materials

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Tumor recurrence and unfavorable bacterial biofilm formation on implants after bone tumor resection remain challenging in clinical settings. However, this dilemma also provides inspiration for the development of bioactive implants and a new route for the management of bone tumors through biofilm formation. Here, based on the characteristic that bacteria prefer to adhere to implants, 3D‐printing bioceramic scaffolds modified with probiotic biofilms are designed to augment antitumor immunity. In comparison with Akkermansia muciniphila, Lactobacillus rhamnosus GG (LGG) is demonstrated to more easily form biofilms on bioceramics and is selected to engineer etched bioceramics. The LGG biofilm subjected to pasteurization guarantees good biocompatibility and enhanced doxorubicin (Dox) loading. Furthermore, the LGG biofilm combined with Dox imparts the scaffolds with multiple properties of direct chemo‐killing for tumor cells and potent immune activation. The modified scaffolds efficiently inhibit bone tumor recurrence and bone metastasis in murine tumor model receives surgical resection. Moreover, based on 3D‐printing technology, the probiotic biofilm modified scaffolds with adjustable shapes are also demonstrated to repair shape‐specific bone defects after tumor elimination. Collectively, the multifunctional 3D‐printing scaffolds realize the integrated treatment of tumor elimination and bone repair, providing a promising strategy for clinical treatment of bone tumors.

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Immunotherapy as a potential treatment approach for currently incurable bone metastasis

Cited by 2 publications

References 55 publications

Bridging the Gap in Understanding Bone Metastasis: A Multifaceted Perspective

Bridging the Gap in Understanding Bone Metastasis: A Multifaceted Perspective

Probiotic Biofilm Modified 3D‐Printing Scaffolds for Improving Chemo‐Immunotherapy of Bone Tumor and Promoting Osteogenesis

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