Immunotherapy and radiotherapy in melanoma: a multidisciplinary comprehensive review

Tagliaferri, Luca; Lancellotta, Valentina; Fionda, Bruno; Mangoni, Monica; Casà, Calogero; Stefani, Alessandro; Pagliara, Monica Maria; D’Aviero, Andrea; Schinzari, Giovanni; Chiesa, S.; Mazzarella, Ciro; Manfrida, S.; Colloca, Giuseppe; Marazzi, Fabio; Morganti, Alessio Giuseppe; Blasi, Maria Antonietta; Peris, Ketty; Valentini, Vincenzo

doi:10.1080/21645515.2021.1903827

Cited by 48 publications

(45 citation statements)

References 97 publications

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“…Combined with immunotherapy, it can enhance the anti-cancer effect [ 28 ]. At present, this treatment shows great result in patients with melanoma [ 29 ], and radiotherapy combined with immunotherapy may be more appropriate for patients with uveal melanoma with poor metastatic immune effect.…”

Section: Discussionmentioning

confidence: 99%

Immunological significance of survival-related alternative splicing in uveal melanoma

Kong

Wang

et al. 2022

Aging

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Uveal melanoma (UM) is a highly malignant intraocular tumor. The imbalance of alternative splicing (AS) is a landmark of tumor initiation and progression. However, there are few studies of AS in UM. Thus, this study aimed to identify a new AS-based prognostic signature and reveal its relationship with tumor-infiltrating immune cells. Univariable Cox regression analysis identified survival-related AS events. The prognostic signature was constructed using the univariable and multivariable Cox regression analyses. Kaplan-Meier survival analysis, the proportional hazard model, and receiver operating characteristic curves verified its prognostic value. Single-sample gene set enrichment analysis was used to analyze immune cell enrichment. The correlation of the risk score with tumorinfiltrating immune cells and immune checkpoint blockade (ICB) genes was examined. We screened 2886 survivalrelated AS events, of which five were selected to build a prognostic predictor. The risk score was positively relevant with ICB key targets (HAVCR2, IDO1, and PDCD1) and the infiltration of T cells, MDSC, and activated B cells. We provided novel and effective indices, including a risk score and clinical nomogram, for prognostic prediction in UM and discussed the potential relationship between survival-related AS events and immune cell infiltration, which is crucial for developing immune-targeted therapy to improve prognosis.

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Section: Discussionmentioning

confidence: 99%

Immunological significance of survival-related alternative splicing in uveal melanoma

Kong

Wang

et al. 2022

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“…Combinatorial treatments have been showing promising results in melanoma treatment, from which can be highlighted hyperthermia and immunotherapy [ 63 ], radiotherapy and immunotherapy [ 64 ], and hyperthermia combined with chemotherapy [ 21 ]. Here, we demonstrated that combining hyperthermia with DTIC can be a promising alternative to apply in a primary or metastatic melanoma treatment, as shown by A375 and MNT-1 cells, respectively.…”

Section: Discussionmentioning

confidence: 99%

Combined Therapy with Dacarbazine and Hyperthermia Induces Cytotoxicity in A375 and MNT-1 Melanoma Cells

Salvador¹,

Bastos²,

Oliveira³

2022

IJMS

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Melanoma is a drug-resistant cancer, representing a serious challenge in cancer treatment. Dacarbazine (DTIC) is the standard drug in metastatic melanoma treatment, despite the poor results. Hyperthermia has been proven to potentiate chemotherapy. Hence, this work analyzed the combined action of hyperthermia and DTIC on A375 and MNT-1 cell lines. First, temperatures between 40 °C and 45 °C were tested. The effect of DTIC on cell viability was also investigated after exposures of 24, 48, and 72 h. Then, cells were exposed to 43 °C and to the respective DTIC IC10 or IC20 of each time exposure. Overall, hyperthermia reduced cell viability, however, 45 °C caused an excessive cell death (>90%). Combinational treatment revealed that hyperthermia potentiates DTIC’s effect, but it is dependent on the concentration and temperature used. Also, it has different mechanisms from the treatments alone, delaying A375 cells at the G2/M phase and MNT-1 cells at the S and G2/M phases. Intracellular reactive oxygen species (ROS) levels increased after treatment with hyperthermia, but the combined treatment showed no additional differences. Also, hyperthermia highly increased the number of A375 early apoptotic cells. These results suggest that combining hyperthermia and DTIC should be more explored to improve melanoma treatment.

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“…However, there is no uniform standard for when to choose RT combined with IT. Some authors have classified the use of RT combined with IT into two main categories based on the time combination: peri-induction radiotherapy (PIR) and post-escape radiotherapy (PER) [ 45 ]. Our study can help to identify patients who are effective for IT and thus further improve the effectiveness of RT combined with IT therapy.…”

Section: Discussionmentioning

confidence: 99%

Pyroptosis-related gene mediated modification patterns and immune cell infiltration landscapes in cutaneous melanoma to aid immunotherapy

Meng

Huang

Qiu

et al. 2021

Aging

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Immunotherapy and radiotherapy in melanoma: a multidisciplinary comprehensive review

Cited by 48 publications

References 97 publications

Immunological significance of survival-related alternative splicing in uveal melanoma

Immunological significance of survival-related alternative splicing in uveal melanoma

Combined Therapy with Dacarbazine and Hyperthermia Induces Cytotoxicity in A375 and MNT-1 Melanoma Cells

Pyroptosis-related gene mediated modification patterns and immune cell infiltration landscapes in cutaneous melanoma to aid immunotherapy

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