Immunotherapy: an option in the management of occupational asthma?

Sastre, Joaquı́n; Quirce, Santiago

doi:10.1097/01.all.0000216851.10571.64

Cited by 30 publications

(12 citation statements)

References 25 publications

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“…There is evidence that specific immunotherapy with some HMW occupational agents has a beneficial effect; this approach is limited as standardised extracts are unavailable for most occupational allergens and there is potential for adverse reactions [94].…”

Section: Commentsmentioning

confidence: 99%

Guidelines for the management of work-related asthma

Baur

Sigsgaard²,

Aasen³

et al. 2012

European Respiratory Journal

181

182

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Work-related asthma, which includes occupational asthma and work-aggravated asthma, has become one of the most prevalent occupational lung diseases. These guidelines aim to upgrade occupational health standards, contribute importantly to transnational legal harmonisation and reduce the high socio-economic burden caused by this disorder.A systematic literature search related to five key questions was performed: diagnostics; risk factors; outcome of management options; medical screening and surveillance; controlling exposure for primary prevention. Each of the 1,329 retrieved papers was reviewed by two experts, followed by Scottish Intercollegiate Guidelines Network grading, and formulation of statements graded according to the Royal College of General Practitioners' three-star system.Recommendations were made on the basis of the evidence-based statements, which comprise the following major evidence-based strategic points. 1) A comprehensive diagnostic approach considering the individual specific aspects is recommended. 2) Early recognition and diagnosis is necessary for timely and appropriate preventative measures. 3) A stratified medical screening strategy and surveillance programme should be applied to at-risk workers. 4) Whenever possible, removing exposure to the causative agent should be achieved, as it leads to the best health outcome. If this is not possible, reduction is the second best option, whereas respirators are of limited value. 5) Exposure elimination should be the preferred primary prevention approach.

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Section: Commentsmentioning

confidence: 99%

Guidelines for the management of work-related asthma

Baur

Sigsgaard²,

Aasen³

et al. 2012

European Respiratory Journal

181

182

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show abstract

“…66 Patients with either a confirmed or suspected OA to a sensitizer should receive close medical monitoring if they continue to have workplace exposure. 2 For OA from certain HMW sensitizers (laboratory animals), allergen immunotherapy may be considered, 67 although there are little data available about the effectiveness of allergen immunotherapy for OA.…”

Section: Differential Diagnosismentioning

confidence: 99%

Occupational asthma: Current concepts in pathogenesis, diagnosis, and management

Dykewicz

2009

Journal of Allergy and Clinical Immunology

130

103

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“…As complete avoidance of this substance is a difficult task, in the last 15 years intense efforts have been made to standardize a latex extract to offer other therapeutic alternatives, such as SIT [5]. As complete avoidance of this substance is a difficult task, in the last 15 years intense efforts have been made to standardize a latex extract to offer other therapeutic alternatives, such as SIT [5].…”

Section: Latexmentioning

confidence: 99%