Immunothérapie et anticorps monoclonaux

Teillaud, Jean‐Luc

doi:10.1051/medsci/2012281003

Cited by 1 publication

(1 citation statement)

References 15 publications

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“…Antibodies can bind to their specific antigens on the target cell surface via their antigen-binding fragment (Fab) portions and interact with effector cells via their fragment crystallizable region (Fc) portions thereby acting as bridges that link the effector to a target. While several classes of human antibodies can mediate ADCC, including IgG, IgA, and IgE, IgG1 is the most used subclass for cancer therapeutic antibodies [ 5 ]. In order for an effector cell to carry out ADCC it must express Fc receptors (FcR) that will bind the antibody [ 6 ].…”

Section: Adcc Mechanismsmentioning

confidence: 99%

Enhancing antibody-dependent cell-mediated cytotoxicity: a strategy for improving antibody-based immunotherapy

Zahavi

Aldeghaither

O’Connell

et al. 2018

Antibody Therapeutics

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The targeting of surface antigens expressed on tumor cells by monoclonal antibodies (mAbs) has revolutionized cancer therapeutics. One mechanism of action of antibody-based immunotherapy is the activation of immune effector cells to mediate antibody-dependent cell-mediated cytotoxicity (ADCC). This review will summarize the process of ADCC, its important role in the efficacy of mAb therapy, how to measure it, and finally future strategies for antibody design that can take advantage of it to improve clinical performance. Statement of Significance:Targeted mAb therapy represents a promising therapeutic strategy for many cancer types. ADCC is a crucial mechanism underlying targeted antibody-based immunotherapy approaches. Many patients have limited responses to mAb therapy and there is a great need for antibodies with enhanced clinical efficacy. Designing and engineering antibodies with enhanced ADCC eliciting properties will improve patient outcomes.

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Section: Adcc Mechanismsmentioning

confidence: 99%