“…Recombinant TNF functioned as an autocrine growth factor which enhanced growth of four human neuroblastoma cell lines. 1 Blocking factors (soluble receptors) for human TNF and lymphotoxin (LT) were found in the serum, cerebral spinal fluid, and tumour cyst fluid (TCF) of human glioma tumour patients. 2 The presence of these receptors would abrogate any tumour cytolytic activity of TNF or LT.…”