Immunosuppressive Therapy in Human Myocarditis

Autoimmunity and Idiopathic Dilated Cardiomyopathy

“…When immunosuppressive therapy has been administered to patients with IDC, the results have been unimpressive. 20 Studies in animals provide more convincing evidence that heart disease may be mediated by heart-specific immune effectors. Such studies, however, rely on histopathologically defined myocarditis as the relevant endpoint, which may be inappropriate with respect to the study of the pathogenesis of IDC.…”