1994
DOI: 10.1016/0020-7519(94)90140-6
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Immunosuppressive proteins secreted by the gastrointestinal nematode parasite Heligmosomoides polygyrus

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Cited by 31 publications
(25 citation statements)
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“…There has consequently been great interest in the potential of Excretory-Secretory molecules from this parasite ("HES") to down-modulate pathology in vivo 17,18 . Indeed, protective effects are seen following treatment of mice with HES products 19 through pathways which are now being identified 18,20 .…”
mentioning
confidence: 99%
“…There has consequently been great interest in the potential of Excretory-Secretory molecules from this parasite ("HES") to down-modulate pathology in vivo 17,18 . Indeed, protective effects are seen following treatment of mice with HES products 19 through pathways which are now being identified 18,20 .…”
mentioning
confidence: 99%
“…For example, the nematode Heligmosomoides polygyrus contains immunomodulatory factors capable of either stimulating (1,2) or inhibiting (3,4) T and B cell responses. With respect to Ascaris suum, we and others have shown that infection with the nematode or the use of its soluble products or extracts at different stages of purification potentiates or suppresses the immune responses (5)(6)(7).…”
mentioning
confidence: 99%
“…Highly effective immune evasion mechanisms are key elements of the long-lasting persistence of parasitic worms. Both parasite-specific and nonspecific immune suppression are well documented (19,47,60). Usually, acute infection stimulates antigen-specific T-cell proliferation, but with increasing exposure to parasite antigens, the immune system becomes hyporesponsive (34).…”
mentioning
confidence: 99%