Immunosuppressive properties of surfactant in alveolar macrophage NR8383

Abstract

Exogenous surfactants and surfactant phospholipid inhibit secretion of proinflammatory cytokines and NO in NR8383 AMs. The inhibitory effects of beractant on oxygen radical and LPS-induced NO formation may result from unique mechanisms of decreasing cell signaling. The anti-inflammatory activity of surfactant products used in the treatment of neonatal respiratory distress syndrome (RDS) may depend upon the specific preparation or dose used.

Effect of ozone exposure and infection on bronchoalveolar lavage: Sex differences in response patterns

“…It is possible that the higher levels in males inhibit the ability of the macrophages to clear bacteria, resulting in a more severe infection. For example, the higher levels of lipids may inhibit the respiratory burst [12,13] induced in response to infection and thereby reduce the levels of reactive oxidant species in males necessary to kill and clear bacteria. Together, these data indicate that surfactant components, including SP-A and lipids, may have a role to play in innate immunity and in infection, in particular, where sex differences in the response to infection are observed.…”

Myeloid differentiation protein 2 silencing decreases LPS-induced cytokine production and TLR4/MyD88 pathway activity in alveolar macrophages

“…NR8383 AMs, a cell line derived from rat alveolar macrophages, retain many of the morphological and functional characteristics of alveolar macrophages. Previous studies in both, freshly obtained AMs and NR8383 cell lines revealed that the early pro-inflammation cytokine secretion, such as TNF-␣ and IL-␤, was highest at 6-12 h following LPS stimulation [19,20]. Minor differences were related to LPS dose and serum type.…”

Oxidized Phospholipid, 1-Palmitoyl-2-(9′-Oxo-Nonanoyl)-Glycerophosphocholine (PON-GPC), Produced in the Lung Due to Cigarette Smoking, Impairs Immune Function in Macrophages

“…Pulmonary surfactant in the epithelial lining fluid (ELF) plays key roles in lung homeostasis. In addition to its effects on lung compliance, pulmonary surfactant modulates pulmonary innate immunity by altering immune cell function [8][9][10]. Pulmonary surfactant consists of proteins and lipids, namely phospholipids.…”