Immunosuppressive properties and mechanism of spergualins in vitro

Direct Cholangioscopy

“…Since it was first advocated by Takada et al in 1974 1 , percutaneous transhepatic cholangioscopy (PTCS) has been utilized to manage a variety of biliary tract disorders. Percutaneous lithotomy using PTCS has become one of the most important nonsurgical forms of treatment for hepatolithiasis.…”

A New Formyl Peptide Receptor-1 Antagonist Conjugated Fullerene Nanoparticle for Targeted Treatment of Degenerative Disc Diseases

“…5 Approximately 66% of surgically obtained herniated human disc specimens show abundant macrophage infiltration, which suggests that they are a prominent source of inflammation and pain. [11][12][13] Our previous study also illustrated abundant macrophage infiltration near the site of disc hernia in a mouse model of disc herniation. 14,15 All these findings support that activated inflammatory cells such as macrophages at local disc hernia sites might be a valid target for therapeutic development.…”

“…25 During inflammation, expression and over-production of proinflammatory factors, such as interleukin (IL)-1, IL-6, tumor necrosis factor-α (TNF-α), and prostaglandin E2 (PGE2), are crucial for triggering progressive activation of immune cells, 26 which have been significantly correlated with the symptoms of herniated disc disease. 13,27 In Raw 264.7 macrophages, LPS induced proinflammatory gene expression in a time-dependent fashion ( Figure S10). As shown in Figure 6, FT-C 60 significantly attenuated LPS-induced mRNA expression of cytokines, including IL-6 ( Figure 6a), TNF-α (Figure 6b), IL-1 (Figure 6c), and COX-II ( Figure 6d).…”

Enhancement of jcat 10-12 T in Nb3Sn wires by artificial Ta inclusions distributed at a nanometre scale

“…for the Large Hadron Collider) lies between 10 and 12 T. However, most investigations with the goal of enhancing the critical current density, j , , of Nb,Sn multifilamentary wires have so far led to considerable progress only at high fields ( B > 18 T). The latter were obtained by adding elements like Ta [l-31 or Ti [4], which are dissolved in the Nb,Sn phase, thus leading to higher p. values and in turn to enhanced B,, values. However, the beneficial effect on j , at high fields observed for Ta or Ti added to Nb,Sn wires is always combined with a lowering ofj, at lower fields, the crossover of j , against B taking place at N 11 T [3, 41. This lowering of j , at lower fields has so far not been fully understood, the indications for a possible reduction of the average A15 grain size given by various authors being contradictory.…”