Immunosuppressive Effect of Quercetin on Dendritic Cell Activation and Function

Huang, Ren‐Yeong; Yu, Y. L.; Cheng, Wan‐Chien; OuYang, Chun‐Nan; Fu, Earl; Chu, Chih‐Liang

doi:10.4049/jimmunol.0903991

Cited by 164 publications

(121 citation statements)

References 59 publications

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“…31 Also, QUE impaired inflammatory cytokine and chemokine production and decreased activation of ERK, JNK, Akt and NFkB in LPS-stimulated dendritic cell. 32 In addition, a semi-synthetic acetyl QUE derivative inhibited LPS-induced nitric oxide production and iNOS expression in J774A.1 MFs. 33 Consistent with these data, luteolin, a tetrahydroxyflavone found in celery and green peppers, reduced JNK phosphorylation and AP-1 activation in microganglia 34 and NFkB, and AP-1 activation in alveolar MFs.…”

Section: Discussionmentioning

confidence: 96%

Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media

Overman

McIntosh

2011

Int J Obes

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Background: Obesity is linked to chronic inflammation in white adipose tissue, which is exacerbated by infiltrating macrophages (MFs). We recently demonstrated that an extract from grape powder (GPE), which is abundant in quercetin (QUE), reduced inflammation in human MFs and prevented MF-mediated inflammation and insulin resistance in human adipocytes. However, we did not know how QUE individually affected these outcomes. Objective and design: We examined the extent to which QUE prevents inflammation in human MFs (that is, differentiated U937 cell line) and cross-talk with human adipocytes (that is, primary cultures of newly differentiated human adipocytes). Methods and results: Treatment of MFs with QUE attenuated the basal expression of inflammatory genes, such as tumor necrosis factor-a, interleukin (IL)-6, IL-8, IL-1b and interferon-g inducible protein-10, and cyclooxygenase-2, a marker of prostaglandin production. QUE also attenuated the abundance of phosphorylated c-Jun N-terminal kinase (JNK) and c-Jun, and IkBa degradation in MFs. Furthermore, conditioned media (CM) obtained from MFs treated with QUE decreased the capacity of this CM to inflame adipocytes and cause insulin resistance as evidenced by decreased: (1) inflammatory gene expression, (2) phosphorylation of JNK and c-Jun, (3) serine residue 307 phosphorylation of insulin receptor substrate (IRS)-1, 4) protein tyrosine phosphatase-1B gene expression and 5) suppression of insulin-stimulated glucose uptake. Conclusion: Taken together, these data suggest that QUE is one of the bioactive components of GPE that prevents inflammation in MFs and MF-mediated insulin resistance in adipocytes.

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Section: Discussionmentioning

confidence: 96%

Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media

Overman

McIntosh

2011

Int J Obes

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“…Such as in the example of the research made by Huang et al (2010), which examines the effect specifically on dendritic cells quercetin, finding inhibition of endocytosis by these cells (Huang et al 2010). Furthermore the authors of this study also describe a decreased production of pro-inflammatory cytokines and chemokines.…”

Section: Suppressive Effects Of the Immune Responsementioning

confidence: 76%

“…Polyphenols as antioxidants can protect cells against oxidative damage and therefore reduce the risk of various degenerative diseases associated with oxidative stress caused by free radicals (Scalbert et al 2005;Huang et al 2010). Among the more important phenolic compounds are flavonoids, which, besides its demonstrated antioxidant activity, has been attributed with a wide range of therapeutic effects, such as cardiotonic, anti-inflammatory, hepatoprotective, antineoplastic and antimicrobial activity.…”

Section: Plants With Antioxidant Activitymentioning

confidence: 99%

Antioxidant activity, antimicrobial and effects in the immune system of plants and fruits extracts

Reyes-Munguía

Carrillo-Inungaray

Carranza‐Álvarez

et al. 2016

Frontiers in Life Science

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Nowadays, medicinal plants, and fruits and vegetables with antioxidant and antimicrobial activity are increasingly studied. In this review, the impact of the medicinal plant extracts on the immune system was discussed. The first part described the phenomenon of oxidative stress, followed by the mechanisms involved in the antioxidant activity and finally discussed on the evaluation of the antioxidant activity of plants and fruits. The second part revised the works that discuss about the antimicrobial activity of plants and fruits extracts, emphasizing in the factors that influence the evaluation of such characteristic. Finally, in the third part, studies on the effect of the plant extracts over the immune response were discussed, describing the results of the enhancer effects, as well as those of the suppressing ones. This work allowed us to discern the necessity of a wider research on the chemical composition of the natural extracts, in order to establish a correlation with the effects observed in health. ARTICLE HISTORY

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“…These results suggest that down-regulation of IDO in BMDC by curcumin may be able to increase immune responses, and reverse immuno-suppressive mechanisms. Immuno-suppressive effects of quercetin on the activation and function of murine BMDC have also been reported [36]. Quercetin, in the dose range of 6-50µM, reduced the expression of pro-inflammatory cytokines, chemokines, MHC class II and co-stimulatory molecules.…”

Section: Discussionmentioning

confidence: 93%

Effects of Aryl−Hydrocarbon Ligands on Dendritic Cell Maturation

Abu-Rezq

Millar

2013

IJI

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Aryl-hydrocarbon receptor (AhR) is a cytosolic receptor found in many cells, including immune cells, and its function has been implicated in metabolic and transcriptional control of immune regulation. In the present study we have investigated the effect of the AhR-ligands, FICZ, I3C, curcumin, quercetin and the ligands precursor tryptophan, on bone marrow-derived dendritic cell (BMDC) maturation and immuno-stimulatory or immuno-suppressive phenotypes. We find that immature and mature BMDC express intracellular AhR. Treatment of BMDC with AhR-ligands during LPS-induced BMDC maturation had no significant effect on the expression of MHC class II, CD40 and CD86, with the exception of I3C which suppressed CD40 expression by BMDC at high doses. However, all AhR-ligands significantly enhanced the secretion of pro-inflammatory cytokines, including IL-6, IL-12p40, TNF-α, and IL-1β. In contrast, only the AhR-ligands FICZ and I3C increased IL-10 and TGF-β secretion. Tryptophan, curcumin, and quercetin significantly suppressed IL-10 secretion without affecting TGF-β secretion. Finally, FICZ and I3C significantly enhanced the expression of the tolerogenic DC enzyme, indoleamine-2, 3-dioxygenase (IDO), while tryptophan, curcumin and quercetin did not change IDO expression. These results suggest that FICZ and I3C can promote a tolerogenic BMDC phenotype consistent with suppression of immune responses by enhancing the secretion of anti-inflammatory cytokines and increasing IDO expression. In contrast, tryptophan, curcumin and quercetin can promote an immuno-stimulatory BMDC phenotype, secreting elevated pro-inflammatory cytokines, which could help in skewing T cell responses towards the development of effector CD4 and CD8 T cell subsets.

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Immunosuppressive Effect of Quercetin on Dendritic Cell Activation and Function

Abstract: Material

Cited by 164 publications

References 59 publications

Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media

Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media

Antioxidant activity, antimicrobial and effects in the immune system of plants and fruits extracts

Effects of Aryl−Hydrocarbon Ligands on Dendritic Cell Maturation

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