Immunosuppressive effect of prolactin-induced protein: a new insight into its local and systemic role in chronic allergic contact dermatitis

Sugiura, S.; Fujimiya, Mineko; Ebise, H; Miyahira, Yoshimitsu; Kato, Ikuo; Sugiura, Yasuo; Kimura, Tomonori; Uehara, Masami; Sato, Hiroshi; Sugiura, Hisashi

doi:10.1111/j.1365-2133.2010.09756.x

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…However, antibody blockade of CD23 inhibited the increase of splenic MCs (data not shown), suggesting the possible involvement of this low affinity IgE receptor. IgE engagement of CD23 on monocytes (which infiltrate the spleen upon oxazolone challenge (Sugiura et al, 2010)) has been shown to induce secretion of CCL3 (Ezeamuzie et al, 2009), a potent chemoattractant for MCs. Collectively, these findings demonstrate a connection between the spleen and the skin in modulating chronic allergic dermatitis, and the putative trafficking of Tregs between the two sites warrants further investigation.…”

Section: Discussionmentioning

confidence: 99%

Mast Cell Interleukin-2 Production Contributes to Suppression of Chronic Allergic Dermatitis

et al. 2011

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SUMMARY The incidence of chronic allergic dermatitis is rapidly increasing. Regulatory control of this disease has not been adequately explored. Here we report that mast cell derived interleukin-2 (IL-2) contributes to the suppression of chronic allergic dermatitis. Mice deficient in IL-2 production, or deficient in mast cells (KitW-sh/W-sh), showed exacerbated dermatitis upon repeated oxazolone challenge when compared to their wild-type counterparts. Adoptive transfer of wild type, but not Il2−/−, mast cells into KitW-sh/W-sh mice dampened the inflammatory response. During the course of disease mast cell expansion occurred at the site of inflammation and also in the spleen, where production of IL-2 by mast cells was markedly enhanced. In the absence of mast cell IL-2 production, the ratio of activated to regulatory T cells at the site of inflammation was increased. Thus, MC-derived IL-2 contributes to the maintenance of suppression in chronic allergic skin inflammation.

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Section: Discussionmentioning

confidence: 99%

Mast Cell Interleukin-2 Production Contributes to Suppression of Chronic Allergic Dermatitis

et al. 2011

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“…PIP is an immunosuppressive molecule. 17,18 Differentially expressed genes in responders to fumaric acid esters…”

Section: Differentially Expressed Genes In the Skin Of Patients With ...mentioning

confidence: 99%

Regulated genes in psoriatic skin during treatment with fumaric acid esters

Onderdijk¹,

Balak²,

Baerveldt³

et al. 2014

Br J Dermatol

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“…Basmaciogullari et al (2000) suggested that binding between PIP and CD4 blocks the CD4-HLA-DR interaction. Moreover, PIP has a local and systemic immunosuppressive effect in mouse chronic allergic contact dermatitis (Sugiura et al, 2010). However, the biological function of the aspartic peptidase residues of human PIP has not been identified.…”

Section: Introductionmentioning

confidence: 99%

Effect of Prolactin-Induced Protein on Human Skin: New Insight into the Digestive Action of This Aspartic Peptidase on the Stratum Corneum and Its Induction of Keratinocyte Proliferation

Sugiura

Tazuke

Ueno³

et al. 2015

Journal of Investigative Dermatology

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Human prolactin-induced protein (PIP) is a major protein found in exocrine fluids such as saliva and sweat. Intriguingly, PIP possesses residues (human PIP (hPIP): PIP (29-63)) that display similarity to the aspartic peptidase candidapepsin. Here, we aimed to determine the effect of PIP as a protease on normal skin structure. Using an adhesive tape-stripping technique, we applied hPIP peptide on the corneocytes of normal-appearing facial skin from infants with eczema and healthy infants and then analyzed the morphological structure of corneocytes with Nile Red fluorescence. We also repeatedly applied the hPIP peptide onto the surface of a three-dimensional (3-D) human skin model and then analyzed any changes to the stratum corneum and epidermis using light microscopy and scanning electron microscopy. In both infant groups, a decrease in hydrophobic lipids from the cornified envelope was observed after treatment with hPIP. The peptide hPIP appeared to digest the fine structure of the stratum corneum and induce a proliferation of epidermal keratinocytes within the 3-D human skin model. Our results suggest that aspartic peptidase of PIP found in sweat or saliva deteriorates the skin barrier in a de novo manner, which potentially leads directly to the proliferation of epidermal keratinocytes without any external antigenic factors.

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Immunosuppressive effect of prolactin-induced protein: a new insight into its local and systemic role in chronic allergic contact dermatitis

Abstract: These findings suggest that PIP might have a local and systemic immunosuppressive effect in mouse chronic ACD.

Cited by 6 publications

References 22 publications

Mast Cell Interleukin-2 Production Contributes to Suppression of Chronic Allergic Dermatitis

Mast Cell Interleukin-2 Production Contributes to Suppression of Chronic Allergic Dermatitis

Regulated genes in psoriatic skin during treatment with fumaric acid esters

Effect of Prolactin-Induced Protein on Human Skin: New Insight into the Digestive Action of This Aspartic Peptidase on the Stratum Corneum and Its Induction of Keratinocyte Proliferation

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