Immunosuppressive effect of cyclosporin A on insect humoral immune response

Fiołka, Marta J.

doi:10.1016/j.jip.2008.03.015

Cited by 34 publications

(35 citation statements)

References 33 publications

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“…In addition to passive external barriers impeding the penetration of the host cuticle, the most hazardous arthropod defense against parasitic fungi is an immune system capable of forming melanin, antimicrobial peptides, eicosanoids, protease inhibitors and detoxification proteins, in combination with attack by circulating hemocytes (Vilcinskas and Götz, 1999;Bulet and Stöcklin, 2005;De Gregario et al, 2002;Stanley, 2006;Takeda and Akira, 2005). Because some secondary metabolites from entomopathogenic fungi have been shown to have immunosuppressive effects (Pedras et al, 2002;Vey et al, 2002;Fiolka, 2008;Pal et al, 2007;Vilcinskas and Götz, 1999), interactions with the host immune system likely constitute an important interface where secondary metabolites serve as a means to resist or suppress animal defenses (Gillespie et al, 2000). Therefore, measurements of their negative effects on arthropods should be evaluated in greater detail at the ''fungal secondary metabolite-host immune system" interface.…”

Section: Definitions Of ''Resistance'' and ''Defense''mentioning

confidence: 99%

Fungal secondary metabolites as modulators of interactions with insects and other arthropods

Rohlfs

Churchill

2011

Fungal Genetics and Biology

230

148

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Section: Definitions Of ''Resistance'' and ''Defense''mentioning

confidence: 99%

Fungal secondary metabolites as modulators of interactions with insects and other arthropods

Rohlfs

Churchill

2011

Fungal Genetics and Biology

230

148

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“…In B. mori (Abraham et al, 1995) and Spodoptera litura (Kim & Yoe, 2003) it is reported that lysozyme activity reaches a maximum at 48 h and is slightly lower 72 h post injection. In G. mellonella immunized with LPS, however, the maximum lysozyme activity is attained 24 h post injection (Fiolka, 2008). Therefore, it is important to conduct further research on lysozyme activity in S. gregaria.…”

Section: ± 1029mentioning

confidence: 99%

Antibacterial activity of lysozyme in the desert locust, Schistocerca gregaria (Orthoptera: Acrididae)

Mohamed¹,

Elmogy²,

Dorrah³

et al. 2013

Eur. J. Entomol.

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Abstract. The ability of biocontrol agents to overcome the immune defense of pests is a crucial issue. This is the first study of lysozyme activity as an inducible humoral component of the defense of Schistocerca gregaria, which depends on the recognition of the elicitor molecules of pathogens and not on epidermal wounding or a spiking effect. The level of lysozyme activity in fat body, haemocytes and haemolymph plasma of naïve and immunologically challenged 5 th instar S. gregaria was evaluated using the zone of inhibition test against Micrococcus lysodeikticus. Various Gram-positive and Gram-negative bacteria as well as peptidoglycans (PGN) and lipopolysacchrides (LPS) of bacterial cell walls induce and increase in the level of lysozyme activity. Escherichia coli induced an increase in the level of activity of lysozyme in the fat body, haemocytes and plasma, but not in mid gut epithelium, 6-12 h after an immunological challenge and then it decreased to the constitutive level after 72 h. This study revealed that in S. gregaria there is a constitutive and a bacteria-inducible level of lysozyme activity, which protects it against infection by both Gram-negative and Gram-positive bacteria.

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“…bras., Brasília, v.52, n.2, p.133-136, fev. 2017 DOI: 10.1590/S0100-204X2017000200008 cyclosporine A is able to decrease the resistance of Galleria mellonella larvae to pathogenic bacteria, for example (Fiolka, 2008). Sandimmun Neoral, an immunosuppressive drug used in organ transplant patients, is one of the main formulations of cyclosporine A (Colombo & Egan, 2010).…”

Section: Suscetibilidade De Operárias De Atta Sexdens Tratadas Com O mentioning

confidence: 99%

“…According to Fiolka (2008) response but loses its immunosuppressive effect after a certain period. The mortality rate of ants injected with water and the fungus reached 30% by the tenth day of the experiment.…”

Section: Suscetibilidade De Operárias De Atta Sexdens Tratadas Com O mentioning

confidence: 99%

Susceptibility of Atta sexdens worker ants treated with the immunosuppressant Sandimmun Neoral to Metarhizium anisopliae

Dornelas

Sarmento

Pedro‐Neto

et al. 2017

Pesq. agropec. bras.

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-The objective of this work was to evaluate if the immunosuppressant Sandimmun Neoral enhances the activity of Metarhizium anisopliae against the leaf-cutting ant Atta sexdens. The vulnerability to the pathogen was measured by comparing the mortality rate of worker ants subjected to the following treatments: immunosuppressant+control, immunosuppressant+M. anisopliae, excipient+control, excipient+M. anisopliae, control+M. anisopliae, and control. Worker ants treated with immunosuppressant+M. anisopliae showed the highest mortality rate in comparison with those subjected to all other treatments. The use of the immunosuppressant together with entomopathogenic fungus controlled leaf-cutting ants in laboratory conditions. Index terms: biological control, Formicidae, immunity, immunosuppression. Suscetibilidade de operárias de Atta sexdens tratadas com o imunossupressor Sandimmun Neoral a Metarhizium anisopliaeResumo -O objetivo deste trabalho foi avaliar se o imunossupressor Sandimmun Neoral favorece a atividade de Metarhizium anisopliae contra a formiga cortadeira Atta sexdens. A vulnerabilidade ao patógeno foi medida ao se comparar a mortalidade de operárias expostas aos seguintes tratamentos: imunossupressor+controle, imunossupressor+M. anisopliae, excipiente+controle, excipiente+M. anisopliae, controle+M. anisopliae e controle. Operárias tratadas com imunossupressor+M. anisopliae apresentaram a maior taxa de mortalidade em comparação às submetidas a todos os outros tratamentos. O uso do imunossupressor juntamente com fungo entomopatogênico controlou as formigas cortadeiras em condições de laboratório.Termos para indexação: controle biológico, Formicidae, imunidade, imunossupressão.

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Immunosuppressive effect of cyclosporin A on insect humoral immune response

Cited by 34 publications

References 33 publications

Fungal secondary metabolites as modulators of interactions with insects and other arthropods

Fungal secondary metabolites as modulators of interactions with insects and other arthropods

Antibacterial activity of lysozyme in the desert locust, Schistocerca gregaria (Orthoptera: Acrididae)

Susceptibility of Atta sexdens worker ants treated with the immunosuppressant Sandimmun Neoral to Metarhizium anisopliae

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