Immunosuppressive CD14+/HLA-DRlow/‒ monocytes in patients with Chagas Disease

Indeterminate Form of Chagas Disease: Some Immunological Insights

“…Recently, we investigated the role of a specific subtype of monocyte/macrophage lineage cells, known as immunosuppressive CD14 + /HLA-DR low/monocytes, in 57 patients with 3 different clinical forms of chronic CD: 26 cardiac, 23 indeterminate, and 8 mixed patients 6 . These monocytes are a kind of myeloid-derived suppressor cells able to suppress the response of T-lymphocytes using the process of direct cell-cell interactions and the production of cytokines 7 .…”

“…Given the immunosuppressive nature of these monocytes, our findings provide evidence that this specific population of cells is involved in the immunological response to the indeterminate form of CD, possibly influencing the control of severe inflammation carried out by T. cruzi in the host tissues. Significantly, it is possible to suggest that the predominance of CD14 + /HLA-DR low/monocytes might have an immunoregulatory role inside the immune system that could ultimately delay (or even prevent) the evolution of the indeterminate form to the symptomatic forms (cardiac and mixed) of CD 6 .…”

Letters to the Editor: Indeterminate form of Chagas Disease: some immunological insights

“…We appreciate the letter to the editor of Matos et al. The authors present their experience in evaluating the role of CD14+/HLA-DRlow/‒ monocytes and CD4+ and CD8+ T lymphocytes in various clinical forms of chronic Chagas disease 1 .…”