Immunosuppressive adherence after kidney transplantation in adult patients treated at an outpatient clinic: a better practice implementation project

Campos, Caroline Silva; Ferreira, Gustavo Fernandes; Bastos, Kamille Vidon; Carbogim, Fábio da Costa; Poveda, Vanessa de Brito; Püschel, Vilanice Alves de Araújo; Santos, Kelli Borges dos

doi:10.1097/xeb.0000000000000262

Cited by 3 publications

(3 citation statements)

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“…However, with gradual enhancement of kidney cell injury, the patient’s kidney self-repair ability is eventually lost. By this time, kidney transplantation or dialysis treatment is usually required, which seriously threatens a patient’s life[ 17 , 18 ]. Guo et al [ 19 ] analyzed the HbA1c level of patients with DN, and showed that the determination of HbA1c level in patients has a positive effect on early kidney injury.…”

Section: Discussionmentioning

confidence: 99%

Role of serum β2-microglobulin, glycosylated hemoglobin, and vascular endothelial growth factor levels in diabetic nephropathy

Yang¹,

Zhao²,

Ma³

2022

WJCC

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BACKGROUND Diabetic nephropathy (DN) is a common complication of type 1 and type 2 diabetes that can lead to kidney damage and high blood pressure. Increasing evidence support the important roles of microproteins and cytokines, such as β2-microglobulin (β2-MG), glycosylated hemoglobin (HbA1c), and vascular endothelial growth factor (VEGF), in the pathogenesis of this disease. In this study, we identified novel therapeutic options for this disease. AIM To analyze the guiding significance of β2-MG, HbA1c, and VEGF levels in patients with DN. METHODS A total of 107 patients with type 2 diabetes mellitus complicated with nephropathy and treated in our hospital from May 2018 to February 2021 were included in the study. Additionally, 107 healthy individuals and 107 patients with simple diabetes mellitus were selected as the control groups. Changes in β2-MG, HbA1c, and VEGF levels in the three groups as well as the different proteinuria exhibited by the three groups were examined. RESULTS Changes in β2-MG, HbA1c, and VEGF levels in the disease, healthy, and simple diabetes groups were significantly different ( P < 0.05). The expression of these factors from high to low were evaluated in different groups by pairwise comparison. In the disease group, high to low changes in β2-MG, HbA1c, and VEGF levels were noted in the massive proteinuria, microproteinuria, and normal urinary protein groups, respectively. Changes in these factors were positively correlated with disease progression. CONCLUSION The expression of serum β2-MG, HbA1c, and VEGF was closely correlated with DN progression, and disease progression could be evaluated by these factors.

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Section: Discussionmentioning

confidence: 99%

Role of serum β2-microglobulin, glycosylated hemoglobin, and vascular endothelial growth factor levels in diabetic nephropathy

Yang¹,

Zhao²,

Ma³

2022

WJCC

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“…'nın yaptıkları çalışmada aile üyelerinin desteğinin immünosupresif uyumunun artmasında önemli bir faktör olduğu belirtilmiştir. 24 Bu çalışmada da benzer şekilde evli olan ve ilaç kullanımına yardımcı kişi olan katılımcılarda İTUÖ toplam puanları daha yüksek bulundu (Tablo 2). Bunun nedeni evde başka birinin varlığının ilaç kullanımında hatırlatıcı, motive edici, destek verici etkisiyle açıklanabilir.…”

Section: Böbrek Nakli Hastaları İçin İlaç İzlem Formuunclassified

Assessment of the Effect of Socio-Demographic and Clinical Characteristics on Immunosuppressive Adherence in Kidney Transplant Patients: A Single Center Study

Akinci

AKİNCİ²

2022

Online Türk Sağlık Bilimleri Dergisi

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Amaç: Bu araştırmada böbrek nakli yapılan hastaların ilaç uyum oranlarını, sosyo-demografik ve klinik özelliklerin immünosupresif uyumuna etkisini değerlendirmek amaçlanmaktadır. Materyal ve Metot: Araştırma tek merkezli olarak kesitsel tanımlayıcı planlandı ve gerçekleştirildi. Araştırmaya organ nakli merkezinde son 6 yılda (2015-2021) böbrek nakli yapılan 210 hasta dahil edildi. Araştırmada veri toplama araçları olarak; “Hasta Bilgi Formu”, Böbrek Nakli Hastaları İçin İlaç İzlem Formu”, “İmmünosüpresif Tedaviye Uyum Ölçeği” kullanıldı. Bulgular: Çalışmaya alınan hastaların İmmünosüpresif Tedaviye Uyum Ölçeği toplam puanları ortalama 11,16±0,82 olarak bulundu ve %57,9’unun immünosupresif ilaç kullanımına çok iyi uyum gösterdiği belirlendi. Sosyodemografik özelliklerden evli, üniversite mezunu, yüksek gelire sahip olanlarda İmmünosüpresif Tedaviye Uyum Ölçeği toplam puanları yüksek bulundu. Klinik özelliklerden ise bir günde kullanılan ilaç adedi arttıkça katılımcıların İmmünosüpresif Tedaviye Uyum Ölçeği puanlarının azaldığı saptandı. İlaç kullanımına yönelik eğitim alanlarda, immünosupresif ilaçların yan etkileri olmayan katılımcılarda İmmünosüpresif Tedaviye Uyum Ölçeği toplam puanları daha yüksek bulundu. Sonuç: Böbrek nakli yapılan merkezlerde hastaların immünosupresif ilaç uyumlarının düzenli olarak kontrol edilmesi, uyumsuzluğa etki eden faktörlerin belirlenerek uyumu arttırıcı doğru yaklaşım yöntemlerinin geliştirilmesi, yaygınlaşması, süreklilik kazanması ve bunun hastane protokollerine eklenmesi gerektiğini düşünmekteyiz.

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“…Epidemiological studies have shown that the number of patients with DKD is increasing year by year, and it is estimated that there will be 592 million patients with DKD by 2035, accounting for about 8%–10% of the global population ( 4 , 5 ). Renal failure in patients with advanced DKD often requires renal replacement therapy or renal transplantation, which seriously jeopardizes the physical and mental health of patients and imposes a substantial economic burden on families and society ( 6 ). Currently, the main therapeutic options for DKD include hypoglycemia, antihypertensive, regulation of lipid metabolism disorders, reduction of urinary protein, and renal replacement therapy for end-stage renal disease ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

A strategic study of acupuncture for diabetic kidney disease based on meta-analysis and data mining

Yu,

Hu,

Yang

et al. 2024

Front. Endocrinol.

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ObjectiveThe specific benefit and selection of acupoints in acupuncture for diabetic kidney disease (DKD) remains controversial. This study aims to explore the specific benefits and acupoints selection of acupuncture for DKD through meta-analysis and data mining.MethodsClinical trials of acupuncture for DKD were searched in eight common databases. Meta-analysis was used to evaluate its efficacy and safety, and data mining was used to explore its acupoints selection.ResultsMeta-analysis displayed that compared with the conventional drug group, the combined acupuncture group significantly increased the clinical effective rate (risk ratio [RR] 1.35, 95% confidence interval [CI] 1.20 to 1.51, P < 0.00001) and high-density lipoprotein cholesterol (mean difference [MD] 0.36, 95% CI 0.27 to 0.46, P < 0.00001), significantly reduced the urinary albumin (MD –0.39, 95% CI –0.42 to –0.36, P < 0.00001), urinary microalbumin (MD –32.63, 95% CI –42.47 to –22.79, P < 0.00001), urine β2-microglobulin (MD –0.45, 95% CI –0.66 to –0.24, P < 0.0001), serum creatinine (MD –15.36, 95% CI –21.69 to –9.03, P < 0.00001), glycated hemoglobin A1c (MD –0.69, 95% CI –1.18 to –0.19, P = 0.006), fasting blood glucose (MD –0.86, 95% CI –0.90 to –0.82, P < 0.00001), 2h postprandial plasma glucose (MD –0.87, 95% CI –0.92 to –0.82, P < 0.00001), total cholesterol (MD –1.23, 95% CI –2.05 to –0.40, P = 0.003), triglyceride (MD –0.69, 95% CI –1.23 to –0.15, P = 0.01), while adverse events were comparable. Data mining revealed that CV12, SP8, SP10, ST36, SP6, BL20, BL23, and SP9 were the core acupoints for DKD treated by acupuncture.ConclusionAcupuncture improved clinical symptoms, renal function indices such as uALB, umALB, uβ2-MG, and SCR, as well as blood glucose and blood lipid in patients with DKD, and has a favorable safety profile. CV12, SP8, SP10, ST36, SP6, BL20, BL23, and SP9 are the core acupoints for acupuncture in DKD, and this program is expected to become a supplementary treatment for DKD.

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Immunosuppressive adherence after kidney transplantation in adult patients treated at an outpatient clinic: a better practice implementation project

Cited by 3 publications

References 9 publications

Role of serum β2-microglobulin, glycosylated hemoglobin, and vascular endothelial growth factor levels in diabetic nephropathy

Role of serum β2-microglobulin, glycosylated hemoglobin, and vascular endothelial growth factor levels in diabetic nephropathy

Assessment of the Effect of Socio-Demographic and Clinical Characteristics on Immunosuppressive Adherence in Kidney Transplant Patients: A Single Center Study

A strategic study of acupuncture for diabetic kidney disease based on meta-analysis and data mining

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