1994
DOI: 10.1111/j.1399-0039.1994.tb02316.x
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Immunosuppression of canine renal allograft recipients by CD4 and CD8 monoclonal antibodies

Abstract: A state of tolerance to MHC mismatched allografts can be generated in rodents by treatment with CD4 and CD8 monoclonal antibodies (mAb). In order to transpose this type of therapy to large animals and ultimately to the clinic, a suitable model is required. To this end we have generated a series of mAb to the canine CD4, CD8, and Thy-1 antigens and have tested their ability to prevent rejection of renal allografts. Donor-recipient pairs were selected from a colony of mongrel dogs in which untreated rejection of… Show more

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Cited by 13 publications
(13 citation statements)
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“…Mongrel dogs were selected on the basis of strong proliferative responses in MLC [6]. In all but one experimental group (group G, see Table l), the donor-recipient combinations were mismatched for both MHC haplotypes.…”
Section: Methodsmentioning
confidence: 99%
“…Mongrel dogs were selected on the basis of strong proliferative responses in MLC [6]. In all but one experimental group (group G, see Table l), the donor-recipient combinations were mismatched for both MHC haplotypes.…”
Section: Methodsmentioning
confidence: 99%
“…The T cell suppressive drugs CsA plus Aza are often used in transplantation studies (19) but have been used rarely in the study of the immune response to soluble proteins (23). The use of CsA may be counterintuitive based on some studies of costimulation blockade that suggest that CsA may prevent tolerance induction (24), but, in this regimen, CsA may play a different role in preventing T cell activation and immune response Canine SC (open circles) was treated with the CsA plus Aza regimen by using ␣-glucosidase as the toleragen and showed no significant immune response (Ͻ1 OD͞ l).…”
Section: Discussionmentioning
confidence: 99%
“…We initially studied a series of 60-day regimens that combined methods used in canine tissue transplantation models including ITI of antigen, T cell-specific immunosuppressive drugs, and monoclonal antibodies that deplete mature T cells (19) as shown in Table 1. The antibody response was measured by a direct ELISA for antirhIDU IgG antibodies.…”
Section: A Tolerance Induction Regimen Combining Low-dose Enzyme Infu-mentioning
confidence: 99%
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“…Indeed, this approach was one of the first to be rigorously investigated with intent on translation to human therapy. Monoclonal antibodies specific for dog CD4, CD8, and thy‐1 have been developed by Waldmann (116) and tested for their ability to both deplete T cells in outbred dogs and prolong renal allograft survival. These agents were most effective when used in combination, but they failed to prolong survival more than a mean of 38 days.…”
Section: Tolerance Strategies In Transitionmentioning
confidence: 99%