Immunosuppression by Thoracic Duct Filtration

Ct, Fitts; Ja, Majeski; Rj, Sharbaugh; Ts, Hargest; Cd, Graber; Gr, Hennigar

doi:10.1097/00007890-197208000-00014

Cited by 5 publications

(1 citation statement)

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“…The thoracic duct was cannulated (Joel and Sautter, 1963) and connected to an extracorporeal lymph circulation system (Fitts et al, 1971). Details of the extracorporeal lymph circulation system and sensization procedure have been published elsewhere (Fitts et al, 1971;Fitts et al, 1972;Sharbaugh et al, 1972). During the cannulation procedure a clavicular lymph node was removed from each animal for control studies.…”

Section: Methodsmentioning

confidence: 99%

Architectural alteration of lymphatic tissue produced by extracorporeal thoracic duct filtration

1977

Journal of Surgical Oncology

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Removal of recirculating lymphocytes from the lymph of calves by extracorporeal thoracic duct filtration results in a state of immunounresponsiveness. Accompanying this is histological evidence of lymphocyte depletion from the lymph organs and structures of the body. Lymph nodes, spleen, hemolymph nodes, Peyer's patches, and thymus appear depleted of the recirculating small lymphocyte. We find this closed model of lymphocyte depletion effective and free of seyere problems with infections and physiological alterations as experienced in mechanical removal, extracorporeal irradiation, and open thoracic duct fistulas.

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Section: Methodsmentioning

confidence: 99%

Architectural alteration of lymphatic tissue produced by extracorporeal thoracic duct filtration

1977

Journal of Surgical Oncology

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Antigen‐coated immunoadsorbents utilized for in vivo depletion of antibodies and lymphocytes with specificity for the antigen

1983

Journal of Surgical Oncology

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Hyperacute rejection of xenografts is thought to be triggered by humoral antibodies. It is known that natural antibodies against dog blood cells have been identified in sheep serum. Dog kidney antigen immunoadsorbent columns were placed in the extracorporeal lymph circuit of two sheep. In vivo studies have shown that these immunoadsorbent columns were effective in depleting the thoracic duct lymph of all antibodies with specificity for the dog kidney antigen. However, these columns were not effective in depleting the thoracic duct lymphocytes bearing surface receptors for the dog kidney antigen. When in vitro studies were carried out, the immunoadsorbent columns were effective in the depletion of both lymphocytes and antibody for the dog kidney antigen. Thus, since a humoral antibody response is thought to be responsible for the hyperacute rejection seen in xenografts, it is possible that these columns might be effective in prolonging xenograft survival.

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Lymphoreticular alterations in neonatally thymectomized and antilymphocyte globulin treated Holstein-Friesian calves

Snider

Pierce

1981

Veterinary Immunology and Immunopathology

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Immunosuppression by Thoracic Duct Filtration

Cited by 5 publications

References 0 publications

Architectural alteration of lymphatic tissue produced by extracorporeal thoracic duct filtration

Architectural alteration of lymphatic tissue produced by extracorporeal thoracic duct filtration

Antigen‐coated immunoadsorbents utilized for in vivo depletion of antibodies and lymphocytes with specificity for the antigen

Lymphoreticular alterations in neonatally thymectomized and antilymphocyte globulin treated Holstein-Friesian calves

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