Immunosuppression by co-trimoxazole.

Arvilommi, Heikki; Vuori, M.; Salmi, A.

doi:10.1136/bmj.3.5829.761-b

Cited by 16 publications

(2 citation statements)

References 2 publications

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“…Antibiotics, such as actinomycin D and doxorubicin, are used as immunosuppressive agents, and some antibiotics used in the treatment of bacterial and fungal infections have also been shown to depress granulocyte and lymphocyte functions in vitro (7, 11-13, 15, 19, 20-22, 25-27) and the immune response in humans and experimental animals (2,3,8,16,21,23).…”

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Antibiotics and suppression of lymphocyte function in vitro

Banck¹,

Forsgren²

1979

Antimicrob Agents Chemother

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The effects on the mitogenic response of human T lymphocytes were studied for 20 different antibiotics. No apparent inhibitory effect could be detected for penicillins, cephalosporins, aminoglycosides, chloramphenicol, sulfamethoxazole, trimethoprim, nalidixic acid, and 5-fluorocytosine. There were effects at high concentrations with erythromycin, clindamycin, and rifampin, and these antibiotics could also be shown to depress the mitogenic response of B lymphocytes. With fusidic acid, nitrofurantoin, and doxycycline there was an inhibiting effect at low concentrations on the mitogenic responses of B and T lymphocytes and on in vitro antibody production. Protein synthesis in unstimulated lymphocytes was also inhibited. Some antibiotics thus may impair the function of human lymphocytes in vitro.Antibiotics, such as actinomycin D and doxorubicin, are used as immunosuppressive agents, and some antibiotics used in the treatment of bacterial and fungal infections have also been shown to depress granulocyte and lymphocyte functions in vitro (7, 11-13, 15, 19, 20-22, 25-27) and the immune response in humans and experimental animals (2, 3,8,16,21,23).The in vitro effects of a wide range of antibiotics on granulocyte chemotaxis and lymphocyte function were recently reported from our laboratory (11, 12). The aim of the present study was to extend the investigations on the in vitro functions of human B and T lymphocytes in the presence of commonly used antibiotics. MATERIALS AND METHODS Antibiotics

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confidence: 99%

Antibiotics and suppression of lymphocyte function in vitro

Banck¹,

Forsgren²

1979

Antimicrob Agents Chemother

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“…In fact, G hilchick et al [5] have found that tri methoprim had an immunosuppressive effect in mice and prolonged skin allograft survival. In a preliminary report we presented evidence for the suppressive effect of the combined drug on antibody response in healthy humans [1], The present paper describes the results of the continuation of the study including some data on trimethoprim or sulphamethoxazole alone.…”

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confidence: 99%

Sulphamethoxazole-Trimethoprim: Effect on Antibody Response in Man

Arvilommi¹,

Vuori²,

Salmi³

1976

Chemotherapy

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The possible immunosuppressive properties of the combination sulphamethoxazole-trimethoprim or either of the agents alone were studied in healthy human volunteers. The effect of the 4-day drug treatment on the antibody synthesis after vaccination was measured by titrating tetanus antitoxin, mumps antibody and Salmonella Hb antibody levels 4 and 5 weeks after vaccination. No significant differences were found in mumps or Salmonella antibody titres in the drug-treated group compared to controls. Tetanus antitoxin levels, however, were significantly lower than in controls after the combined drug. When a fourfold or greater increase in tetanus antitoxin titre was obtained in 75% of controls, the respective figures were 38% in the sulphamethoxazole-trimethoprim-treated group (p < 0.05), 45% in the trimethoprim group (p > 0.05), and 50% in the sulphamethoxazole group (p > 0.05). The implications of these findings are discussed.

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Preclinical Toxicity Testing of Co-trimoxazole and Other Trimethoprim/Sulfonamide Combinations

Dayan¹

1983

Inhibition of Folate Metabolism in Chemotherapy

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Immunosuppression by co-trimoxazole.

Cited by 16 publications

References 2 publications

Antibiotics and suppression of lymphocyte function in vitro

Antibiotics and suppression of lymphocyte function in vitro

Sulphamethoxazole-Trimethoprim: Effect on Antibody Response in Man

Preclinical Toxicity Testing of Co-trimoxazole and Other Trimethoprim/Sulfonamide Combinations

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