Immunosuppression and Virus Infection of Rodents

Nathanson, Neal; González‐Scarano, Francisco

doi:10.1016/b978-0-12-095785-9.50036-6

Cited by 2 publications

(1 citation statement)

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“…Nathanson and Scarano reported that anti-rabies VNA titers increased throughout infection, reaching the highest levels during the terminal phase of infection [38]. Similarly, Kuzmin et al reported VNA 12 months following experimental inoculation with West Caucasian bat virus and Irkut virus [39].…”

Section: Discussionmentioning

confidence: 99%

Unique characteristics of bat rabies viruses in big brown bats (Eptesicus fuscus)

2012

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Rabies virus infection has been documented in several North American bat species, including Eptesicus fuscus. The virus-host relationship between bats and rabies virus (RV) is not well understood. The incidence of non-lethal RV exposure, based on the presence of viral neutralizing antibodies, demonstrates that exposure to RV does not always lead to clinical infection in bats. It is unknown how the route of exposure, rabies virus variant, or health of the bat affects the outcome following exposure. This paper describes the pathogenesis of two big brown bat RV variants in homologous host species. Our study demonstrates that RV variants obtained from the same species of bat from similar geographical areas may result in a diverse clinical progression of disease.

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Section: Discussionmentioning

confidence: 99%

Unique characteristics of bat rabies viruses in big brown bats (Eptesicus fuscus)

2012

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Animal welfare and colony management in cancer research

Schiffer

1997

Breast Cancer Res Treat

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The use of animals in cancer research continues to be important for the study of tumor biology, the development and testing of new therapies, and risk assessment. The new knowledge generated from this research contributes to the health and welfare not only of human beings, but also of animals which develop cancer. However, the use of animals for cancer research is a privilege which carries with it scientific, professional, and moral obligations. The three tenets of a sound animal research program include good science, humane care, and regulatory compliance. Recognizing the complex interactions in the tumor-animal model, the investigator needs to address a wide range of issues during experimental design and implementation including animal welfare concerns, complicating factors in colony management, and compliance with laws, regulations, and policies. Therefore, both practical and philosophical considerations enjoin researchers to maintain the highest standards of animal care.

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Immunosuppression and Virus Infection of Rodents

Cited by 2 publications

References 98 publications

Unique characteristics of bat rabies viruses in big brown bats (Eptesicus fuscus)

Unique characteristics of bat rabies viruses in big brown bats (Eptesicus fuscus)

Animal welfare and colony management in cancer research

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