Immunostimulatory oligodeoxynucleotide from<i>Bifidobacterium longum</i>suppresses Th2 immune responses in a murine model

Takahashi, Noritoshi; Kitazawa, Haruki; Iwabuchi, Noriyuki; Xiao, Jin‐zhong; Miyaji, Kazuhiro; Iwatsuki, Keiji; Saito, Tadao

doi:10.1111/j.1365-2249.2006.03111.x

Cited by 60 publications

(56 citation statements)

References 34 publications

(37 reference statements)

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“…It has been reported that some probiotics inhibit IgE production through improvement of Th1/Th2 imbalance by inducing production of Th1-type cytokines and suppressing production of Th2-type cytokine (IL-4) Yoshida et al, 2010). On the other hand, it has also been reported that some probiotics suppress the excess production of IgE and the development of allergic inflammation through the suppression of excessive Th2 cell response rather than by inducing production of Th1-type cytokines (Iwabuchi et al, 2007;Iwabuchi et al, 2009;Kanzato et al, 2008;Niers et al, 2005;Takahashi et al, 2006). It has been reported that one strain of Bifidobacterium suppresses the production of Th2 cell-attracting chemokines and that one strain of LAB induces Th2 cell apoptosis (Iwabuchi et al, 2009;Kanzato et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, it has also been reported that some probiotics decrease IgE production by suppressing excess production of Th2-type cytokine rather than by inducing production of Th1-type cytokines to ameliorate development of type-1 allergies (Iwabuchi et al, 2007;Iwabuchi et al, 2009;Kanzato et al, 2008;Niers et al, 2005;Takahashi et al, 2006). Shinshu University.…”

Section: Introductionmentioning

confidence: 99%

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Tetragenococcus halophilus MN45 Ameliorates Development of Atopic Dermatitis in Atopic Dermatitis Model NC/Nga Mice

Ohata

Yoshida

Masuda

et al. 2011

FSTR

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We investigated the inhibitory effects of oral administration of Tetragenococcus halophilus MN45 (MN45) isolated from miso on the development of atopic dermatitis (AD) using NC/Nga AD model mice. NC/Nga mice were fed a diet containing 0.05% or 0.5% MN45 (0.05% or 0.5% MN45 groups) or lacking MN45 (control group). Mice were sensitized and boosted with picryl chloride by topical application once per week. IgE production in serum, clinical score and ear thickness in both MN45 groups were significantly suppressed. In addition, IgE and IL-17 production from splenocytes from mice in both MN45 groups were significantly decreased. IL-4 production from splenocytes in the 0.5% MN45 group decreased significantly, while IL-10 production from splenocytes in the 0.05% MN45 group increased significantly. These results demonstrate that intake of MN45 is effective in preventing and alleviating the development of type-1 allergic symptoms in humans.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tetragenococcus halophilus MN45 Ameliorates Development of Atopic Dermatitis in Atopic Dermatitis Model NC/Nga Mice

Ohata

Yoshida

Masuda

et al. 2011

FSTR

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“…18,19) In plasmacytoid (lymphoid) dendritic cells, IFN-/ is produced by recognition of the bacterial body via Toll like receptor (TLR). 20) Based on these findings, we speculate that B. longum BB536 is recognized by lymphoid dendritic cells via TLR-2 and/or TLR-9, [21][22][23] resulting in the release of IFN-/ and subsequently activation of NK cells. In addition, since neutrophils also constantly secret IFN-/, which exerts autocrine action on the neutrophils themselves, we speculate that the increase in neutrophilic function (bactericidal activity) is also an immunostimulatory effect induced by B. longum BB536.…”

Section: Discussionmentioning

confidence: 99%

Effects ofBifidobacterium longumBB536 Administration on Influenza Infection, Influenza Vaccine Antibody Titer, and Cell-Mediated Immunity in the Elderly

Namba

Hatano

Yaeshima

et al. 2010

Bioscience, Biotechnology, and Biochemistry

103

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“…Both cytokines are TH2-derived, with IL-4 acting on Bcells to induce class-switching and on mast cells to induce degranulation and further cytokine production and IL-5 inducing eosinophil degranulation. Specific strains found to inhibit IL-4 and IL-5 production include L. casei (Schiffer et al, 2009), L. rhamnosus (Ghadimi et al, 2008), B. longum (Takahashi et al, 2006) and B. infantis (Dev et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

The Immunomodulatory Effects of Probiotic Bacteria on Peripheral Blood Mononuclear Cells (Pbmcs) of Allergic Patients

Sheikh¹,

Shalaby²,

Hafez³

et al. 2014

American Journal of Immunology

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Allergic diseases represent major health burden. An allergic reaction is characterized by a disrupted Thelper 1⁄T-helper 2 balance toward a preferential allergen specifically induced TH2 cytokine profile, causing allergic inflammation Probiotic bacteria have various benificial effects in many pathologic situation. Studies have shown that the bacteria present in the intestinal micro flora play a role in the TH1/TH2 balance and its modulation can promote the control of infectious and immune processes. Testing the effects of probiotic bacteria on TH1/TH2 cytokine production by peripheral blood mononuclear cells of allergic patients and control subjects. This study included 24 patients allergic to date pollen and 16 healthy control subjects. PBMC of both groups were separated and cultured for 72 h with date pollen allergen (home-made) in the presence or absence of Lactobacillus rhamnosus ATCC 7469 (Living and dead) and Cphycocyanin (extracted from Spirulina platensis). The cell culture supernatants were collected to measure Interlukin 4 and Interferon gamma by quantitative ELISA. Incubation of PBMCs of allergic patients with living Lactobacillus rhamnosus ATCC 7469 showed marked reduction in IL4 production (median IL4 concentarion = 3.9 pg.) compared to PBMCs callenged with pollen alone (mediam IL4 conentration = 52.6 pg). When PBMC were incubated with living Lactobacillus rhamnosus in absence of allergen significant increase in and IFNγ (median concentration = 42.75 pg.) was obtained, compared to PBMC challenged with allergen alone (median = 22.8 pg). When PBMCs incubated with heat killed Lactobacillus rhamnosus either in presence or absence of the offending allergen, marked reduction in IL4 production was obtained (median = 10.6, 3.6 pg respectively) compared to PBMC incubated with allergen alone (median = 52.6 pg). When PBMCs incubated with dead Lactobacillus rhamnosus, marked increase in IFNγ production was obtained (median = 49 pg) when compared to IFNγ production by PBMC challenged with allergen (median 22.8 pg). PBMCs challenged with PC in the presence or absence of allergen showed marked decrease of IL4 production (median = 19.8, 17 pg respectively) when compared to PBMC incubated with the offending allergen alone (median = 52.6 pg). PBMCs incubated with PC showed significant increase of and IFNγ production (median= 319.6 pg) when compared to PBMC incubated with the offending allergen alone (median = 22.8 pg). Conclusion Lactobacillus rhamnosus ATCC 7469 and C-phycocyanin (extracted from Spirulina platensis) inversed the TH1: TH2 polarization in allergic patients and could be a promissing line of treatmen.

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Immunostimulatory oligodeoxynucleotide fromBifidobacterium longumsuppresses Th2 immune responses in a murine model

Abstract: SummaryWe have reported previously that novel immunostimulatory sequence (

Cited by 60 publications

References 34 publications

Tetragenococcus halophilus MN45 Ameliorates Development of Atopic Dermatitis in Atopic Dermatitis Model NC/Nga Mice

Tetragenococcus halophilus MN45 Ameliorates Development of Atopic Dermatitis in Atopic Dermatitis Model NC/Nga Mice

Effects ofBifidobacterium longumBB536 Administration on Influenza Infection, Influenza Vaccine Antibody Titer, and Cell-Mediated Immunity in the Elderly

The Immunomodulatory Effects of Probiotic Bacteria on Peripheral Blood Mononuclear Cells (Pbmcs) of Allergic Patients

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