Immunostimulatory effects of dimerized lysozyme (KLP-602) on the nonspecific defense mechanisms and protection against furunculosis in salmonids

Siwicki, Andrzej K.; Klein, P.; Morand, M.; Kiczka, W; Studnicka, M.

doi:10.1016/s0165-2427(97)00140-2

Cited by 56 publications

(43 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lysozyme is characterized by its ability to lyse susceptible bacteria, but the molecule also possesses numerous other anti-inflammatory, antibacterial and antiviral functions (reviewed in Sava, 1996). Lysozyme concentrations can vary naturally (among eggs/chicks within clutches and through time in adult birds) (Saino et al, 2002), and can positively affect immune function, health status and growth when orally administered (Sava, 1996;Siwicki et al, 1998;Humphrey et al, 2002;Brundige et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Effects of immune supplementation and immune challenge on oxidative status and physiology in a model bird: implications for ecologists

Crommenacker

Horrocks

Versteegh

et al. 2010

Journal of Experimental Biology

View full text Add to dashboard Cite

SUMMARYOne route to gain insight into the causes and consequences of ecological differentiation is to understand the underlying physiological mechanisms. We explored the relationships between immunological and oxidative status and investigated how birds cope physiologically with the effects of immune-derived oxidative damage. We successively implemented two experimental manipulations to alter physiological status in a model bird species: the homing pigeon (Columba livia). The first manipulation, an immune supplementation, was achieved by oral administration of lysozyme, a naturally occurring and non-specific antimicrobial enzyme. The second manipulation, an immune challenge, took the form of an injection with lipopolysaccharide, a bacterial endotoxin. Between groups of lysozyme-treated and control birds, we compared lipopolysaccharide-induced changes in reactive oxygen metabolites, total antioxidant capacity, haptoglobin, oxygen consumption, body mass and cloacal temperature. Lysozyme supplementation intensified the lipopolysaccharide-induced inflammatory response and generated short-term oxidative and metabolic costs. We identified significant interactions between immune supplementation and immune challenge in terms of reactive oxygen metabolites, haptoglobin and oxygen consumption. Our study provides alternative interpretations of differences in oxidative and immunological indices and demonstrates that these indices can also fluctuate and interact across very short time scales, reflecting something akin to current 'health status' or 'physiological condition'. These ephemeral effects highlight the need to broadly consider current physiological condition when drawing conclusions that relate physiology to ecology and evolution.Supplementary material available online at

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of immune supplementation and immune challenge on oxidative status and physiology in a model bird: implications for ecologists

Crommenacker

Horrocks

Versteegh

et al. 2010

Journal of Experimental Biology

View full text Add to dashboard Cite

show abstract

“…These include anti-viral action by forming an insoluble complex with acidic viruses, enhanced antibiotic effects, anti-inflammatory and antihistaminic actions, direct activation of immune cells and anti-tumor action [74][75][76][77].…”

Section: Applicationsmentioning

confidence: 99%

Functional Proteins and Peptides of Hen’s Egg Origin

Abdou¹,

Kim²,

Satô³

2013

Bioactive Food Peptides in Health and Disease

View full text Add to dashboard Cite

“…Furthermore, lysozyme has antitumor (Osserman et al 1973) and antiviral activities (Lee-Huang et al 2005), and it enhances the immune system (Siwicki et al 1998). The mechanisms of these activities remain unclear, and the dominant questions involve how HL recognizes pathogenic microbes.…”

Section: Introductionmentioning

confidence: 99%

Lysozyme's lectin-like characteristics facilitates its immune defense function

Zhang

Eckert

et al. 2017

Quart. Rev. Biophys.

View full text Add to dashboard Cite

Abstract. Interactions between human lysozyme (HL) and the lipopolysaccharide (LPS) of Klebsiella pneumoniae O1, a causative agent of lung infection, were identified by surface plasmon resonance. To characterize the molecular mechanism of this interaction, HL binding to synthetic disaccharides and tetrasaccharides representing one and two repeating units, respectively, of the O-chain of this LPS were studied. pH-dependent structural rearrangements of HL after interaction with the disaccharide were observed through nuclear magnetic resonance. The crystal structure of the HL-tetrasaccharide complex revealed carbohydrate chain packing into the A, B, C, and D binding sites of HL, which primarily occurred through residue-specific, direct or water-mediated hydrogen bonds and hydrophobic contacts. Overall, these results support a crucial role of the Glu35/Asp53/Trp63/Asp102 residues in HL binding to the tetrasaccharide. These observations suggest an unknown glycan-guided mechanism that underlies recognition of the bacterial cell wall by lysozyme and may complement the HL immune defense function.

show abstract

Immunostimulatory effects of dimerized lysozyme (KLP-602) on the nonspecific defense mechanisms and protection against furunculosis in salmonids

Cited by 56 publications

References 10 publications

Effects of immune supplementation and immune challenge on oxidative status and physiology in a model bird: implications for ecologists

Effects of immune supplementation and immune challenge on oxidative status and physiology in a model bird: implications for ecologists

Functional Proteins and Peptides of Hen’s Egg Origin

Lysozyme's lectin-like characteristics facilitates its immune defense function

Contact Info

Product

Resources

About