Immunoserologic Pepsin Detection in The Saliva as a Non-Invasive Rapid Diagnostic Test for Laryngopharyngeal Reflux

Ocak, Emre; Kubat, Gözde; Yorulmaz, İrfan

doi:10.5152/balkanmedj.2015.15824

Cited by 56 publications

(64 citation statements)

References 26 publications

(22 reference statements)

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“…These findings are interesting because the correlation between EER and airway disease is gradually gaining recognition increasing the need for new standards and diagnostic standards for EER related to GER (2,17). In fact, as with other diseases affecting the respiratory system, this study does strongly suggesting a relationship of occult aspiration bronchial exacerbations (6).…”

Section: Discussionmentioning

confidence: 69%

“…Pepsin exhibits maximal activity at pH 2.0 and is inactive at pH >6.5. However, pepsin is not fully denatured or irreversibly inactivated until pH 8.0 (2,9). The presence of pepsin is then a better predictor of AERD in patients with respiratory symptoms.…”

Section: Introductionmentioning

confidence: 99%

“…Pepsin plays the leading role in the formation of GER and related diseases since studies claim the key role of pepsin in mucosal lesions. Therefore, pepsin can be a good alternative diagnostic method, particularly in patients with non-acid reflux (2). The gastric enzyme pepsin is a member of the family of aspartic proteins, synthesized by the chief cells of the gastric fundus epithelium.…”

Section: Introductionmentioning

confidence: 99%

“…GERD is a term referring to the clinical symptoms, which is caused by advanced gastroesophageal reflux (GER). According to the position statement of the Committee on Speech, Voice, and Swallowing Disorders of the American Academy of Otolaryngology-Head and Neck Surgery, the laryngopharyngeal reflux (LPR) is the backflow of stomach contents into the laryngopharynx (2). Even if heartburn and regurgitation represent the most common clinical manifestation, sometimes GERD is asymptomatic and causes extraesophageal symptoms such as asthma, dysphonia, sore or burning throat, excessive throat clearing, chronic cough, globes pharyngeus, apnea, laryngospasm, laryngitis, dysphagia, and postnasal drip (3).…”

Section: Introductionmentioning

confidence: 99%

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Bronchial reacutization and gastroesophageal reflux: is there a potential clinical correlation?

et al. 2016

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Background: Pepsin plays a role in gastroesophageal reflux (GER). Aims of this study were to verify if pepsin could be the cause of frequent bronchial exacerbations and to check if the persistence of chronic respiratory symptoms were correlated with pre-existing respiratory diseases.Methods: From January to May 2016, 42 patients underwent a diagnostic bronchoscopy. All patients had a history of at least one bronchial exacerbation during the previous year. Bronchial lavage fluid specimens were obtained. A semiquantitative assessment of pepsin in the samples was carried out based on the intensity of the test sample.Results: Pepsin was present in 37 patients (88%), but in patients with bronchial asthma and chronic obstructive pulmonary disease (COPD), the finding of pepsin in the bronchoalveolar fluid was 100%. There was a strong positive statistical correlation between pepsin detection and radiological signs of GER (ρ=0.662), and between pepsin detection and diagnosis (ρ=0.682). No correlation was found between the bacteriology and the presence of pepsin in the airways (ρ=0.006). Conclusions:The presence of pepsin in the airways shows the occurrence of reflux. The persistence of respiratory symptoms by at least 2 months suggest an endoscopic bronchial examination. This straightforward test confirms the cause possible irritation of the airways and may prevent further diagnostic tests, such as an EGD or pH monitoring esophageal.

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Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bronchial reacutization and gastroesophageal reflux: is there a potential clinical correlation?

et al. 2016

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“…It has been used to detect pepsin A in patients with both gastro-oesophageal reflux disease (GORD) and extra-oesophageal reflux into the laryngopharynx and airways [1][2][3][4][5].…”

Section: To the Editormentioning

confidence: 99%