Immunosensor of Nitrofuran Antibiotics and Their Metabolites in Animal-Derived Foods: A Review

Abstract

Nitrofuran antibiotics have been widely used in the prevention and treatment of animal diseases due to the bactericidal effect. However, the residual and accumulation of their metabolites in vivo can pose serious health hazards to both humans and animals. Although their usage in feeding and process of food-derived animals have been banned in many countries, their metabolic residues are still frequently detected in materials and products of animal-derived food. Many sensitive and effective detection methods have been developed to deal with the problem. In this work, we summarized various immunological methods for the detection of four nitrofuran metabolites based on different types of detection principles and signal molecules. Furthermore, the development trend of detection technology in animal-derived food is prospected.

Rapid Quantitative Detection for Nitrofurantoin Based on Nitrogen-Doped Highly Photoluminescent Carbon Dots

“…Nitrofurans is special kind of antibiotic that play a significant role in the prevention of infections due to inhibiting growth of bacteria. , In addition, they are often used as an feed additive to promote animal growth in animal husbandry . However, excessive use of antibiotics can lead to antibiotic residues in food and the environment, posing lots of threats to human health, including toxic effects, bacterial resistance to antibiotics, and so on. , NFT was previously used in veterinary and agricultural settings, but it has been banned .…”

Interpenetrated Robust Metal–Organic Framework with Urea-Functionality-Decked Pores for Selective and Ultrasensitive Detection of Antibiotics and Oxo-anions

“…5 For example, several nitrofuran derivatives like nitrofurazone (NFT) and nitrofurantoin (NFZ) have been used clinically as antibiotics for the treatment of urinary tract infections and as topical agents. 6 Alternatively, sulfonamide antibacterial drugs like sulfamethazine (SMZ) are frequently used in veterinary medicine to treat livestock diseases, such as respiratory tract and gastrointestinal infections. 7 Overuse of these drugs can contaminate the food source (derived from the animal) and water (polluted by nondegraded antibiotics) with microdoses of antibiotics.…”

“…This increases the risk of long-term development and spread of antibiotic-resistant bacteria (ARB) and antibiotic-resistance genes, which possess a major threat to the ecosystem. , Furthermore, acute and chronic toxicity are only a few of the negative consequences that exposure to antibiotic residues and their altered metabolites may have on human physiology . For example, several nitrofuran derivatives like nitrofurazone (NFT) and nitrofurantoin (NFZ) have been used clinically as antibiotics for the treatment of urinary tract infections and as topical agents . Alternatively, sulfonamide antibacterial drugs like sulfamethazine (SMZ) are frequently used in veterinary medicine to treat livestock diseases, such as respiratory tract and gastrointestinal infections .…”

miR-128-3p inhibits intramuscular adipocytes differentiation in chickens by downregulating FDPS

“…Poultry meat is an important animal origin food source which can provide essential nutrients [ 1 ]. The nutritional value of poultry meat has recently received tremendous attention [ 2 ].…”