Immunosenescence: Implications for vaccination programmes in adults

Lang, Pierre Olivier; Govind, Sheila; Michel, Jean Pierre; Aspinall, Richard; Mitchell, Wayne

doi:10.1016/j.maturitas.2011.01.011

Cited by 65 publications

(37 citation statements)

References 78 publications

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“…Despite the outstanding importance of the immunosenescence, both in chronological age (Aw et al 2007;Lan et al 2011) and the so-called premature immunosenescence (as HIV infection, Molina-Pinelo et al 2009;Blanco et al 2010;Appay et al 2011), the only phenotypic characteristic that could be associated, up to date, with mortality was the CD4:CD8 T cell ratio in the very old (Ferguson et al 1995;Wikby et al 2008). Nevertheless, this result has been only described in the Swedish population, and it has not been validated in cohorts from other geographic regions.…”

Section: Discussionmentioning

confidence: 99%

Thymic function failure and C-reactive protein levels are independent predictors of all-cause mortality in healthy elderly humans

Ferrando‐Martínez

Romero-Sánchez

Solana

et al. 2011

AGE

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Relationship between thymic function and elderly survival has been suspected, despite the fact that formal proof is elusive due to technical limitations of thymic function-related markers. The newly described sj/β-TREC ratio allows now, by overcoming these limitations, an accurate measurement of thymic output in elderly humans. Thus, the aim of this study was to determine the impact of thymic function and inflammatory markers on healthy elderly human survival. Healthy volunteers (n=151), aged over 65, were asked to participate (CARRERITAS cohort). Subjects were excluded if diagnosed of dementia or, during the last 6 months, had clinical data of infection, hospital admission, antitumor therapy, or any treatment that could influence the immune status. Thymic function (sj/β-TREC ratio), CD4:CD8 T cell ratio, C-reactive protein, interleukin-6, and neutrophilia were determined from basal samples. All basal variables and age were associated with 2-year allcause mortality. Multivariate analysis showed that only thymic function and C-reactive protein were independently associated with time to death. In conclusion, we show, for the first time, the direct role of thymic function in human survival. C-reactive protein raise is also a marker of mortality in the healthy elderly, in a thymic-independent way.

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Section: Discussionmentioning

confidence: 99%

Thymic function failure and C-reactive protein levels are independent predictors of all-cause mortality in healthy elderly humans

Ferrando‐Martínez

Romero-Sánchez

Solana

et al. 2011

AGE

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“…1 Many infectious diseases in adults can be prevented by a 'life-long vaccination strategy' with vaccines designated to certain age groups and comorbid conditions. However, despite efforts to increase the awareness on adult vaccination and to implement solid vaccination strategies through frequently updated guidelines, vaccination rates are still not at the desired levels.…”

Section: Introductionmentioning

confidence: 99%

Missed opportunities for Hepatitis B vaccination among diabetic patients

Özışık

Tanrıöver

Başaran

et al. 2015

Human Vaccines & Immunotherapeutics

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Many infectious diseases in adults can be prevented by a 'life-long vaccination strategy'. Hepatitis B disease burden was shown to be higher in diabetic patients. American Advisory Committee on Immunization Practices recommends to vaccinate diabetic patients against hepatitis B since 2011. In this study, we aimed to determine hepatitis B virus serology status to determine the rates of diabetic patients who have indications for hepatitis B vaccination. The electronic database of the hospital was searched to identify adult patients aged above 18 years and with hemoglobin A 1 C levels of 6.5% or above, who have been seen at General Medicine Outpatient Clinics of a university hospital during a 3-year period. A total of 5187 patients were included in the study. After exclusion of patients with an incomplete serological panel, 1358 patients were included for further analyses. Twenty-nine percent of the patients had indication for hepatitis B vaccination, whereas only 8% were vaccinated. This study showed that nearly one third of patients who had hepatitis B serological data had an indication for hepatitis B vaccination and this is a clear reflection of the need to keep a lifelong vaccination log and inquire vaccination data.

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“…With the introduction of several successful vaccines during the twentieth, major achievements included the development of the polio vaccine in the 1950s and the eradication of smallpox during the 1960s and 1970s have been obtained. While the last has contributed to avoid 300 million cases and probably saved 100 million lives [1], the incidence of poliomyelitis has been reduce by 100%, and by 90% for diphtheria, tetanus, measles, mumps and rubella [2].…”

mentioning

confidence: 99%

“…Although the immunosenescence process greatly contributes to this less-than optimal immune response to vaccination this decline is however not uniform within this population [5], frailer individuals demonstrating the poorer responses [4]. While the exact benefit of vaccination in the global aged population is still widely debated, the overall body of evidence nevertheless suggests that vaccination is however beneficial [2]. Because healthy and active aging is the result of a lifelong practice of preventive behaviours, in addition to a balanced diet, lifelong learning, physical activity and appropriate screening, vaccination can also greatly promote healthy aging and quality of life.…”

mentioning

confidence: 99%

“…Mandate influenza vaccine to Health Care Workers (HCWs) was thought to be the best option for increasing their vaccine coverage rate. Indeed, despite knowing that vaccination is a patientsafety imperative, many healthcare professionals are not immunized against influenza [2]. Multiple reasons exist for HCW resistance to influenza vaccination, including cost, inconvenience, and fear of needles.…”

mentioning

confidence: 99%

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