2014
DOI: 10.1016/j.ijcard.2014.04.128
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Immunosenescence and inflammation characterize chronic heart failure patients with more advanced disease

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Cited by 53 publications
(39 citation statements)
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“…Patients with more advanced heart failure, as reflected by low AT, demonstrate an increased number of neutrophils. This relative neutrophilia is accompanied by a decreased number of lymphocytes, characterised by higher proportions of terminally differentiated CD4 + and CD8 + T-subsets [43]. These data are consistent with molecular mechanisms driving a T-cell immunosenescent state [44].…”
Section: Discussionsupporting
confidence: 57%
“…Patients with more advanced heart failure, as reflected by low AT, demonstrate an increased number of neutrophils. This relative neutrophilia is accompanied by a decreased number of lymphocytes, characterised by higher proportions of terminally differentiated CD4 + and CD8 + T-subsets [43]. These data are consistent with molecular mechanisms driving a T-cell immunosenescent state [44].…”
Section: Discussionsupporting
confidence: 57%
“…It has been long recognized that myocardial aging is associated with increased interstitial fibrosis, hypertrophy, inflammation, stiffness, and mild contractile dysfunction (25). Several mechanisms have been proposed to explain this condition, including mitochondrial impairment (43), cardiomyocyte intrinsic factors (25), and deregulated immune responses (44)(45)(46).…”
Section: Discussionmentioning
confidence: 99%
“…Chronic heart failure (CHF), a form of cardiovascular disease prevalent in the elderly, has also been associated with a state of chronic inflammation . High levels of pro‐inflammatory cytokines: TNF, IL‐1 β and IL‐6 have been detected in patient myocardium and peripheral tissues . Furthermore, it was shown that pro‐inflammatory cytokine levels in the plasma affect clinical outcomes, as patients with higher levels of IL‐6 were associated with worse CHF pathogenesis .…”
Section: Effects Of Immunosenescence In Other Age‐related Diseasesmentioning
confidence: 99%
“…155 Furthermore, it was shown that pro-inflammatory cytokine levels in the plasma affect clinical outcomes, as patients with higher levels of IL-6 were associated with worse CHF pathogenesis. 155 In addition, the expression of Toll-like receptor-4 (TLR4) receptor, as well as TLR4associated pro-inflammatory cytokines, were shown to be increased in hearts of patients with CHF. 156 The contribution of TLR4 expression towards CHF pathogenesis was also reported in another finding, with increased levels of TLR4 expression on monocytes in patients with CHF.…”
Section: Effects Of Immunosenescence In Other Age-related Diseasesmentioning
confidence: 99%