Immunosenescence and inflamm-ageing in COVID-19

Zinatizadeh, Mohammad Reza; Zarandi, Peyman Kheirandish; Ghiasi, Mohsen; Kooshki, Hamid; Mohammadi, Mozafar; Amani, Jafar; Rezaei, Nima

doi:10.1016/j.arr.2022.101818

Cited by 28 publications

(18 citation statements)

References 196 publications

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“…33 Age has been continuously identi ed as a risk factor for severe COVID-19 disease and death. [2][3][4][5]33 In our study, the odds of in-hospital mortality increased as age increased. In addition, the only signi cant odds of in-hospital death were found in patient groups over 40 years old.…”

Section: Discussionmentioning

confidence: 78%

“…In contrast, the lower-middle percentile (26th -50th ) had a signi cantly increased risk of death only for ages 50-70, which was previously identi ed as overlapping with high-risk periods (50 or 55-64 years old). 2,39 Consequently, when accounting for the deleterious effects of low income, 3,16,38 age, [2][3][4][5]33 and race/ethnicity 35,39 on COVID-19 patients, older working Hispanic patients are at a disproportionate risk that requires further evaluation. Previous research on the effects of COVID-19 on the Hispanic population has similar results and found that Hispanic patients between 55-64 years old had six times the agespeci c death rate per 100,000 compared to White patients.…”

Section: Discussionmentioning

confidence: 99%

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Racial, Regional disparities of in-hospital mortality among patients with 2019 novel coronavirus disease (COVID-19): Evidence from NIS sample in 2020

Kim

Medina

Park

2023

Preprint

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Background: Because of the racial and regional inequalities regarding COVID-19, more research is required to deconstruct how the pandemic impacted different populations. This study explores differences in COVID-19 in-hospital mortality rates by patient and hospital factors. Hospital factors are differences in mortality by rurality level, region, and census division. Methods: The latest 2020 United States NIS data was used to obtain a population-based estimate for patients with COVID-19. We conducted a cross-sectional retrospective data analysis on the NIS dataset. Sampling weights were used for all statistical analyses to represent nationwide in-hospital mortality of patients with COVID-19. We investigated how patients with COVID-19 and other characteristics, like region or race, are associated with in-hospital death using the multivariate survey logistic regression analysis. Additionally, we ran the models using census divisions to determine more specific regional mortality variance. Results: Of 1,002,655 patients, 88.9% did not have an in-hospital death (n=178,369), and 11.1% died in-hospital (n=22,162). Among them, we used the weighted logistic regression results examining predictors of in-hospital death. Patients older than 70 were 10 times more likely to have an in-hospital death than patients younger than 40 (p<.001). Male patients were 37% more likely to have an in-hospital death than female patients (p<.001). Hispanic patients were 25% more likely to have in-hospital deaths than white patients (p<.001). In the sub-analysis, Hispanic patients in the 50-60, 60-70, and 70 age groups were 32%, 34%, and 24%, respectively, more likely to die in-hospital than white patients (p<.001). Conclusion: Health disparities in the COVID-19 pandemic occurred across races and regions and must be addressed to prevent future deaths. Age and comorbidities like diabetes have a well-established link to increased disease severity, and we have linked both to higher mortality risk. Low-income patients had a significantly increased risk of in-hospital death starting at over 40 years old. In sum, Hispanic patients were at increased odds of mortality because of age and economics. Policy concerns should be raised to illuminate populations uniquely burdened by the COVID-19 pandemic to direct more significant research and funding to alleviate inequalities and mitigate future suffering.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Racial, Regional disparities of in-hospital mortality among patients with 2019 novel coronavirus disease (COVID-19): Evidence from NIS sample in 2020

Kim

Medina

Park

2023

Preprint

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“…24 Immunosenescence, inflammaging, epigenetic aging, telomere attrition, age-related decreases in respiratory function, increasing comorbidities, and so on, were the probable contributors to vulnerability to SARS-CoV-2 in the elderly. [25][26][27][28][29] Immunosenescence and inflammaging are two most characteristic, unique features associated with aging of the human Receiving the COVID-19 vaccine is now a powerful measure to reduce the progression to severe and/or critical disease after SARS-CoV-2 infection. However, the COVID-19 vaccine does have several adverse events, 30 including CTD, sarcoidosis, and AE-ILD after vaccination.…”

Section: Discussionmentioning

confidence: 99%

“…In the United States, it was reported that the incidence of hospitalization and death from COVID‐19 pneumonia was approximately 1300‐fold higher in the 65‐ to 74‐year‐old group and 8700‐fold higher in the 85‐year‐old group than in the 5‐ to 17‐year‐old group 24 . Immunosenescence, inflammaging, epigenetic aging, telomere attrition, age‐related decreases in respiratory function, increasing comorbidities, and so on, were the probable contributors to vulnerability to SARS‐CoV‐2 in the elderly 25–29 . Immunosenescence and inflammaging are two most characteristic, unique features associated with aging of the human immune system.…”

Section: Discussionmentioning

confidence: 99%

Risk factors associated with COVID‐19 pneumonia in Chinese patients with pre‐existing interstitial lung disease during the SARS‐CoV‐2 pandemic

Shao,

Shi,

Chen

et al. 2023

Journal of Medical Virology

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In China, the emergence of a nationally widespread epidemic infection of severe acute respiratory syndrome coronavirus 2 (SARS‐COV‐2) has appeared within a month since December 7, 2022. To evaluate the risk factors for suffering from coronavirus disease 2019 (COVID‐19) pneumonia due to infection with SARS‐CoV‐2 in different kinds of interstitial lung disease (ILD) patients with diverse immunizations, we conducted this retrospective study on 525 patients with ILDs who underwent regular follow‐up in our ILD clinic. Among them, 128 ILD patients (24.4%) suffered from COVID‐19 pneumonia after SARS‐CoV‐2 infection. Patients were older with a male predominance in the pneumonia group than in the nonpneumonia group (65.0 ± 10.0 years vs. 56.4 ± 11.7 years, p < 0.001, 55.5% vs. 39.5%, p = 0.002, respectively). Connective tissue disease‐associated ILD (CTD‐ILD) (25%), idiopathic pulmonary fibrosis (23.4%), and interstitial pneumonia with autoimmune features (21.1%) were the main pre‐existing ILDs in the pneumonia group. In Cox multivariable analysis, only male sex and corticosteroid use were risk factors for COVID‐19 pneumonia after infection. Two or three doses of vaccination were a protective factor for pre‐existing ILD patients suffering from COVID‐19 pneumonia. More than two doses of vaccination were strongly recommended for pre‐existing ILD patients, particularly for males who were administered corticosteroids.

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“…'s discovery that the diminishing health state of the elderly might have a significant detrimental influence on the conserved CDC frequency with age among healthy patients is noteworthy. [7,[12][13][14][15][16][17][18][19][20]…”

Section: Introductionmentioning

confidence: 99%

Aging and Changes in White Blood Cells Count and Immunity: A Systematic Review

Abukanna¹,

AlAnazi²,

AlAnazi³

et al. 2022

Clin Cancer Investig J

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It is unclear why aging causes a drop in lymphoid-biased HSC numbers and a decline in lymphoid progenitor quality. One possibility is that stem and progenitor cells have inherently programmed processes at work, which would imply that these cells have an internal clock that controls their functionality and lifetime. This study aims to summarize current evidence regarding the Effect of aging on White Blood Cells Count and immunity. The PubMed database and EBSCO Information Services were utilised to choose the articles. In our review, all pertinent articles related to our subject and other publications were used. Other articles that have nothing to do with this subject were not included. The group members looked through a certain format in which the data had been extracted. The WBC count merits consideration as a potentially clinically helpful indicator of survival in individuals aged 75 and older, particularly in women. Monocyte count and total white blood cell count both peaked at the 50th and 97.5th quantiles at birth before significantly declining in the first six months of life. A relatively gradual decline persisted until the age of two. Contrary to the tendency for the neutrophil count, the lymphocyte count peaked in early childhood and subsequently fell as people aged. As the immune system is exposed to infections and environmental non-self-antigens more often after early infancy. This pattern appears to represent the development of acquired and adaptive immune responses.

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Immunosenescence and inflamm-ageing in COVID-19

Cited by 28 publications

References 196 publications

Racial, Regional disparities of in-hospital mortality among patients with 2019 novel coronavirus disease (COVID-19): Evidence from NIS sample in 2020

Racial, Regional disparities of in-hospital mortality among patients with 2019 novel coronavirus disease (COVID-19): Evidence from NIS sample in 2020

Risk factors associated with COVID‐19 pneumonia in Chinese patients with pre‐existing interstitial lung disease during the SARS‐CoV‐2 pandemic

Aging and Changes in White Blood Cells Count and Immunity: A Systematic Review

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