2013
DOI: 10.1186/1742-4933-10-16
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Immunosenescence and gender: a study in healthy Cubans

Abstract: BackgroundThe progressive decline in the immune function during ageing is termed immunosenescence. Previous studies have reported differences between males and females in the distribution and cell responses of lymphocyte subsets. Most studies of immunosenescence have been done in populations of industrialized countries living in a rather cold environment, and facing lower antigenic challenges such as Cytomegalovirus (CMV). The aim of this study was to determine the effect of ageing on lymphocytes in a populati… Show more

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Cited by 22 publications
(21 citation statements)
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References 58 publications
(68 reference statements)
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“…T cells are presumed to follow a certain surface-marker differentiation, first losing CD45RA expression, then CCR7 (or CD62L), and finally regaining CD45RA (57). 11 (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) ns (***)…”
Section: Original Articlementioning
confidence: 99%
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“…T cells are presumed to follow a certain surface-marker differentiation, first losing CD45RA expression, then CCR7 (or CD62L), and finally regaining CD45RA (57). 11 (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) ns (***)…”
Section: Original Articlementioning
confidence: 99%
“…Several studies have reported age‐dependent cellular changes to the immune system, for example, changes in number and function of innate immune cells subsets as well as subsets of the adaptive immune system . Age associated changes are most pronounced for the adaptive immune cell subsets.…”
mentioning
confidence: 99%
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“…These interactions allow cross-communication between different cell types, at different hierarchical levels, translating environmental signals into molecular signals (2,7). The pro-inflammatory profile becomes strategic throughout the lifespan (8)(9)(10)(11) -an increase of cytokine secretion, also thought to be associated with the influence of CMV-infection, may be at least partly responsible for age-associated degenerative disorders (12)(13)(14)(15)(16). Previous studies usually investigated individual roles of different cytokines, inflammatory mediators or metabolic factors in the age-related physiological alterations (17)(18)(19)(20)(21).…”
Section: Introductionmentioning
confidence: 99%
“…It is well documented that with decrease in age naïve CD8 + T cells, highly differentiated CD8 + T cells lacking CD28 accumulate and those CD8 + CD28 − T cells upregulate the expression of CD45RA. Additionally, these cells show signs of replicative senescence such as a decreased proliferation ability, shortened telomeres, impairment of telomerase activity, and upregulation of CD57 ( 3 , 4 ). These facts have been frequently associated with chronic CMV infection ( 5 ).…”
Section: Introductionmentioning
confidence: 99%