Immunosenescence: a product of the environment?

Su, Dongming; Aw, Danielle; Palmer, Donald B.

doi:10.1016/j.coi.2013.05.018

Cited by 37 publications

(34 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, these studies highlight that the microenvironment in ageing SLO can potentially contribute towards peripheral immunosenescence. 17 The stromal network represents key components to the functional activity of SLO and we noted that the stromal network undergoes dramatic changes with age. In particular, the enlargement of the T-cell zone stroma, which may account for the loss of the distinct boundary between the T-cell and B-cell areas.…”

Section: Discussionmentioning

confidence: 99%

“…13,14 However, given the essential role that the microenvironment plays in the development and activation of many immune cell types, 15,16 changes in the tissue architecture may also contribute towards immunosenescence. 17 Indeed, we and others have observed that regression of the thymus is accompanied by significant alterations of the thymic microenvironment, [18][19][20][21] and such changes are believed to contribute towards the reduced thymic function that is observed in the aged. [22][23][24] The spleen is a secondary lymphoid organ that is responsible for initiating immune responses to bloodborne antigens.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Disorganization of the splenic microanatomy in ageing mice

Hilliard

Nishikawa

et al. 2016

Immunology

Self Cite

View full text Add to dashboard Cite

SummaryThe precise mechanisms responsible for immunosenescence still remain to be determined, however, considering the evidence that disruption of the organization of primary and secondary lymphoid organs results in immunodeficiency, we propose that this could be involved in the decline of immune responses with age. Therefore, we investigated the integrity of the splenic microarchitecture in mice of increasing age and its reorganization following immune challenge in young and old mice. Several differences in the anatomy of the spleen with age in both the immune and stromal cells were observed. There is an age-related increase in the overall size of the white pulp, which occurs primarily within the T-cell zone and is mirrored by the enlargement of the T-cell stromal area, concurrent to the distinct boundary between T cells and B cells becoming less defined in older mice. In conjunction, there appears to be a loss of marginal zone macrophages, which is accompanied by an accumulation of fibroblasts in the spleens from older animals. Furthermore, whereas the reorganization of the white pulp is resolved after several days following antigenic challenge in young animals, it remains perturbed in older subjects. All these age-related changes within the spleen could potentially contribute to the age-dependent deficiencies in functional immunity.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Disorganization of the splenic microanatomy in ageing mice

Hilliard

Nishikawa

et al. 2016

Immunology

Self Cite

View full text Add to dashboard Cite

show abstract

“…The changes to the immune system affect both the innate (Panda et al 2009) and adaptive arms of the immune system (Su et al 2013).…”

Section: Mdscs Immunosenescence and Ageingmentioning

confidence: 99%

Ageing and myeloid-derived suppressor cells: possible involvement in immunosenescence and age-related disease

Bueno

Sant’Anna

Lord

2014

AGE

View full text Add to dashboard Cite

Infections, cancer and autoimmune diseases occur more frequently in the elderly, and although many factors contribute to this, the age-related remodelling of the immune system, termed immunosenescence, plays a major role. Over the last two decades, studies have evaluated the effect of ageing on both the adaptive and innate arms of the immune system and demonstrated compromised function in several cells including lymphocytes (naïve, effector and memory), regulatory T and B cells, monocytes, neutrophils and NK cells. In addition, a well-documented feature of ageing is the increase in systemic inflammatory status (inflammageing), with raised serum levels of IL6, TNFα and CRP as well as reduced IL10. Recently, myeloid-derived suppressor cells have been the focus of many reports as these cells show immunosuppressive properties and are present in higher frequency during infections, cancer and autoimmunity. Importantly, there have been publications showing increased numbers of myeloid-derived suppressor cells in aged mice and humans. In this review, we discuss the current literature on myeloid-derived suppressor cells, their possible role in altered immune function in the elderly, and whether it may be possible to manipulate these cells to alleviate age-related immune dysfunction.

show abstract

“…His data showed that MDSCs induced the expression of microRNA101, which targets the Notch co-repressor C terminal binding protein 2 (CtBP2). This ultimately resulted in a derepression of CtBP2 target genes to increase the stemness and persistence of ovarian cancer cells [31]. …”

Section: Reprogramming the Tumor Microenvironment To Promote Tumor Rementioning

confidence: 99%